Molecular & Cellular Therapeutics, RCSI
123 St Stephens Green, Dublin 2
2016 to date: Research Lecturer (StAR programme), Royal College of Surgeons in Ireland (RCSI)
2016 to date: Adjunct Assistant Professor, Trinity College Dublin
2014 to 2016: Senior Research Fellow, Trinity College Dublin
2011 to 2014: Research Fellow, Trinity College Dublin
2010 to 2011: Medical Advisor (Immunotherapeutics), Bristol-Myers Squibb
2008 to 2010: Scientific Programme Manager, Science Foundation Ireland (SFI)
2006 to 2008: Principal Scientist, GlaxoSmithKline
2005 to 2006: Postdoctoral Researcher, University of Pennsylvania
Trinity College Dublin, B.A, Moderatorship in Genetics, 1994 – 1998 University of Pennsylvania, PhD, Pharmacology, 2001 – 2006
The Curtis laboratory seeks to understand the fundamental cellular mechanisms by which the molecular clock governs innate immunity and inflammation. We have a particular interest in how clock controlled mitochondrial metabolism impacts innate immune function. The dominance of the molecular clock in controlling all aspects of our physiology is gathering acceptance. The molecular clock drives 24-hour rhythms (termed circadian rhythms) in cellular function and physiology and 43% of all protein coding genes showed circadian rhythms in transcription somewhere in the body. It is now clear that the molecular clock and time-of-day exerts profound effects on innate immunity. Functioning autonomous clocks have been identified in innate immune cells such as macrophages, dendritic and natural killer (NK) cells impacting on inflammation, sepsis, viral infection, NK cytolytic activity, neurodegeneration and even the efficacy of vaccines. Daily variations in inflammatory episodes, such as asthmatic exacerbations, arthritis joint pain, and cardiovascular disease infer further the significance of the circadian clock on immune function. Circadian disruption, as imposed by shift work, augments the inflammatory response and increases susceptibility to many of these inflammatory conditions. Understanding the mechanisms by which the clock controls innate immunity has implications for not only how we treat but also the time-of-day we target inflammatory conditions.
Transgenics, Vascular Biology, Immunity Infection & Inflammation, Infectious Diseases, Population health
2017: L'Oréal-UNESCO For Women in Science 2017 Fellowship, L'Oréal-UNESCO
2012: Winner, Roche Medal, Researcher of the Year, Trinity Biomedical Science Institute, Roche Pharmaceuticals
2006: Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) Junior Investigator Award for Women 2006, ATVB
Colas RA, Souza PR, Walker ME, Burton M, Marques RM, Zasłona Z, Curtis AM, Dalli J.
Impaired Production and Diurnal Regulation of Vascular RvDn-3 DPA Increases Systemic Inflammation and Cardiovascular Disease.
Circ Res. 2018 Feb 5. pii: CIRCRESAHA.117.312472. doi: 10.1161/CIRCRESAHA.117.312472. Epub ahead of print PMID: 29437834 (Feb 2018)
Lyall LM, Wyse CA, Celis-Morales CA, Lyall DM, Cullen B, Mackay D, Ward J, Graham N, Strawbridge RJ, Gill JMR, Ferguson A, Bailey MES, Pell JP, Curtis AM, Smith DJ
Seasonality of depressive symptoms in women but not in men: A cross-sectional study in the UK Biobank cohort.
J Affect Disord. 2018 Jan 4;229:296-305. doi: 10.1016/j.jad.2017.12.106. PMID: 29329063 (Jan 2018)
Caroline E. Sutton, Conor M. Finlay, Mathilde Raverdeau, James O. Early, Joseph DeCourcey, Zbigniew Zaslona, Luke A. J. O’Neill, Kingston H. G. Mills & Annie M. Curtis
Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease
Nature Communications. 2017 Dec 12;8(1):1923. doi: 10.1038/s41467-017-02111-0. PMID: PMID: 29234010 (Dec 2017)
Zaslona Z1, Case S, Early JO, Lalor SJ, McLoughlin RM, *Curtis AM, * O'Neill LA (*both authors contributed equally)
The circadian protein BMAL1 in myeloid cells is a negative regulator of allergic asthma
Am J Physiol Lung Cell Mol Physiol. 2017 Mar 23:ajplung.00072.2017. doi: 10.1152/ajplung.00072.2017. PMID: 28336811 (Mar 2017)
Wyse CA, Celis Morales CA, Graham N, Fan Y, Ward J, Curtis AM, Mackay D, Smith DJ, Bailey ME, Biello S, Gill JM, Pell JP.
ADVERSE METABOLIC AND MENTAL HEALTH OUTCOMES ASSOCIATED WITH SHIFTWORK IN A POPULATION-BASED STUDY OF 277 168 WORKERS IN UK BIOBANK.
Ann Med. 2017 Feb 6:1-23. doi: 10.1080/07853890.2017.1292045. PMID: 28166415 (Feb 2017)
McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP
Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion.
Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7778-E7787 PMID: 27856732 (Nov 2016)
Early JO, Curtis AM.
Immunometabolism: Is it under the eye of the clock?
Semin Immunol. 2016 Oct;28(5):478-490. doi: 10.1016/j.smim.2016.10.006. Review. PMID: 27884543 (Oct 2016)
Curtis AM, Fagundes CT.
Understanding the Role of Cellular Molecular Clocks in Controlling the Innate Immune Response
Methods Mol Biol. 2016;1390:301-16. doi: 10.1007/978-1-4939-3335-8_19 PMID: 26803637 (Jan 2016)
Curtis AM, Fagundes CT, Yang G, Palsson-McDermott EM, Wochal P, McGettrick AF, Foley NH, Early JO, Chen L, Zhang H, Xue C, Geiger SS, Hokamp K, Reilly MP, Coogan AN, Vigorito E, FitzGerald GA, O'Neill LA
Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1.
Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7231-6. PMID: 25995365 (Jun 2015)
Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnston DG, Jiang JK, Israelsen WJ, Keane J, Thomas C, Clish C, Vander Heiden M, Xavier RJ, O'Neill LA.
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.
Cell Metab. 2015 Jan 6;21(1):65-80 PMID: 25565206 (Jan 2015)
Curtis AM, Bellet MM, Sassone-Corsi P, O'Neill LA.
Circadian clock proteins and immunity.
Immunity. 2014 Feb 20;40(2):178-86 PMID: 24560196 (Feb 2014)
Yang G, Paschos G, Curtis AM, Musiek ES, McLoughlin SC, FitzGerald GA
Knitting up the raveled sleave of care.
Sci Transl Med. 2013 Nov 20;5(212):212rv3 PMID: 24259052 (Nov 2013)
Curtis AM, Edelberg J, Jonas R, Rogers WT, Moore JS, Syed W, Mohler ER 3rd
Endothelial microparticles: sophisticated vesicles modulating vascular function.
Vasc Med. 2013 Aug;18(4):204-14 PMID: 23892447 (Aug 2013)
Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA.
Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
Nature. 2013 Apr 11;496(7444):238-42 PMID: 23535595 (Apr 2013)
Curtis AM, FitzGerald GA
Platelet microRNAs: Novy Mir* or mired in human complexity?
Circ Res. 2013 Feb 15;112(4):576-8. PMID: 23410874 (Feb 2013)
Curtis AM, Zhang L, Medenilla E, Gui M, Wilkinson PF, Hu E, Giri J, Doraiswamy V, Gunda S, Burgert ME, Moore JS, Edelberg JM, Mohler ER 3rd
Relationship of microparticles to progenitor cells as a measure of vascular health in a diabetic population.
Cytometry B Clin Cytom. 2010 Sep;78(5):329-37 PMID: 20544836 (Sep 2010)
Curtis AM, Wilkinson PF, Gui M, Gales TL, Hu E, Edelberg JM
p38 mitogen-activated protein kinase targets the production of proinflammatory endothelial microparticles.
J Thromb Haemost. 2009 Apr;7(4):701-9 PMID: 19192109 (Apr 2009)
Price TS, Baggs JE, Curtis AM, Fitzgerald GA, Hogenesch JB.
WAVECLOCK: wavelet analysis of circadian oscillation.
Bioinformatics. 2008 Dec 1;24(23):2794-5 PMID: 18931366 (Dec 2008)
Reilly DF, Curtis AM, Cheng Y, Westgate EJ, Rudic RD, Paschos G, Morris J, Ouyang M, Thomas SA, FitzGerald GA.
Peripheral circadian clock rhythmicity is retained in the absence of adrenergic signaling.
Arterioscler Thromb Vasc Biol. 2008 Jan;28(1):121-6. PMID: 17975121 (Jan 2008)
Curtis AM, Cheng Y, Kapoor S, Reilly D, Price TS, Fitzgerald GA
Circadian variation of blood pressure and the vascular response to asynchronous stress.
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3450-5 PMID: 17360665 (Feb 2007)
Woon PY, Curtis AM, Kaisaki PJ, Argoud K, Wallace KJ, Bihoreau MT, FitzGerald GA, Gauguier D
Genomic organization of the rat Clock gene and sequence analysis in inbred rat strains.
Genomics. 2006 Feb;87(2):208-17 PMID: 16376516 (Feb 2006)
Curtis AM, Fitzgerald GA.
Central and peripheral clocks in cardiovascular and metabolic function.
Ann Med. 2006;38(8):552-9 PMID: 17438670 (Jan 2006)
Rudic RD, McNamara P, Reilly D, Grosser T, Curtis AM, Price TS, Panda S, Hogenesch JB, FitzGerald GA
Bioinformatic analysis of circadian gene oscillation in mouse aorta.
Circulation. 2005 Oct 25;112(17):2716-24 PMID: 16230482 (Oct 2005)
Rudic RD, Curtis AM, Cheng Y, FitzGerald G.
Peripheral clocks and the regulation of cardiovascular and metabolic function.
Methods Enzymol. 2005;393:524-39 PMID: 15817310 (Jan 2005)
Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB, Fitzgerald GA.
BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis.
PLoS Biol. 2004 Nov;2(11):e377 PMID: 15523558 (Nov 2004)
Curtis AM, Seo SB, Westgate EJ, Rudic RD, Smyth EM, Chakravarti D, FitzGerald GA, McNamara P.
Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.
J Biol Chem. 2004 Feb 20;279(8):7091-7 PMID: 14645221 (Feb 2004)
Bairead E, Harmon DL, Curtis AM, Kelly Y, O'Leary C, Gardner M, Leahy DT, Vaughan P, Keegan D, O'Morain C, O'Donoghue D, Shanahan F, Parfrey NA, Quane KA.
Association of NOD2 with Crohn's disease in a homogenous Irish population.
Eur J Hum Genet. 2003 Mar;11(3):237-44 PMID: 12673278 (Mar 2003)
Dr Richard Carroll
George Timmons (PhD / 4 yrs)