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Reschke C., Almeida Silva L.A., Norwood B.A., Senthilkumar K., Morris G., Sanz-Rodriguez A., Conroy R., Costard L., Neubert V., Bauer S., Schorge S., Pasterkamp R.J., Rosenow F., Henshall D.C. .
A calcium-sensitive feed-forward loop regulating the expression of the ATP-gated purinergic P2X7 receptor via specificity protein 1 and microRNA-22
Volume 1864, Issue 2, February 2017, Pages 255–266     PMID: 27840225      (Nov 2016)

Henshall D.C., Hamer H., Pasterkamp R.J., Goldstein D.B., Kjems J., Prehn J.H., Schorge S., Lamottke K., Rosenow F. .
MicroRNAs in epilepsy: pathophysiology and clinical utility
Lancet Neurol 15, 1368-1376 (2016)     PMID: 27839653      (Nov 2016)

Almeida Silva, L.F., Engel T., Reschke C.R., Conroy R., Langa E., Henshall D.C .
Distinct behavioral and epileptic phenotype differences in 129/P mice compared to C57BL/6 mice subject to intraamygdala kainic acid-induced status epilepticus
Epilepsy Behav 64,186-194 (2016)     PMID: 27744244      (Oct 2016)

Christina Gross, Xiaodi Yao, Tobias Engel, Durgesh Tiwari, Lei Xing, Shane Rowley, Scott W. Danielson, Kristen T. Thomas, Eva M. Jimenez-Mateos, Lindsay M. Schroeder, Raymund Y.K. Pun, Steve C. Danzer, David C. Henshall, Gary J. Bassell .
MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset
Gross, Christina et al. Cell Reports , Volume 17 , Issue 1 , 37 - 45     PMID: na      (Sep 2016)

Sebastián-Serrano Á, Engel T, de Diego-García L, Olivos-Oré LA, Arribas-Blázquez M, Martínez-Frailes C, Pérez-Díaz C, Millán JL, Artalejo AR, Miras-Portugal MT, Henshall DC, Díaz-Hernández M. .
Neurodevelopmental alterations and seizures developed by mouse model of infantile hypophosphatasia are associated with purinergic signalling deregulation.
Hum Mol Genet. 2016 Jul 27. pii: ddw248     PMID: 27466191      (Jul 2016)

Fischer W, Franke H, Krügel U, Müller H, Dinkel K, Lord B, Letavic MA, Henshall DC, Engel T. .
Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models.
PLoS One. 2016 Jun 9;11(6):e0156468. doi: 10.1371/journal.pone.0156468. eCollection 2016.     PMID: 27281030      (Jun 2016)

Jimenez-Pacheco A, Diaz-Hernandez M, Arribas-Blázquez M, Sanz-Rodriguez A, Olivos-Oré LA, Artalejo AR, Alves M, Letavic M, Miras-Portugal MT, Conroy RM, Delanty N, Farrell MA, O'Brien DF, Bhattacharya A, Engel T, Henshall DC. .
Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy.
J Neurosci. 2016 Jun 1;36(22):5920-32. doi: 10.1523/JNEUROSCI.4009-15.2016     PMID: 27251615      (Jun 2016)

Cattani AA, Allene C, Seifert V, Rosenow F, Henshall DC, Freiman TM. .
Involvement of microRNAs in epileptogenesis.
Epilepsia. 2016 Jul;57(7):1015-26. doi: 10.1111/epi.13404. Epub 2016 May 21     PMID: 27207608      (May 2016)

D'Orsi B, Engel T, Pfeiffer S, Nandi S, Kaufmann T, Henshall DC, Prehn JH. .
Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury.
J Neurosci. 2016 Apr 20;36(16):4564-78. doi: 10.1523/JNEUROSCI.3780-15.2016     PMID: 27098698      (Apr 2016)

Mooney C, Becker BA, Raoof R, Henshall DC .
EpimiRBase: a comprehensive database of microRNA-epilepsy associations.
Bioinformatics. 2016 May 1;32(9):1436-8. doi: 10.1093/bioinformatics/btw008. Epub 2016 Jan 8.     PMID: 26748106      (Jan 2016)

Mooney C, Raoof R, El-Naggar H, Sanz-Rodriguez A, Jimenez-Mateos EM, Henshall DC .
High Throughput qPCR Expression Profiling of Circulating MicroRNAs Reveals Minimal Sex- and Sample Timing-Related Variation in Plasma of Healthy Volunteers.
PLoS One. 2015 Dec 23;10(12):e0145316. doi: 10.1371/journal.pone.0145316. eCollection 2015.     PMID: 26699132      (Dec 2015)

Jimenez-Mateos EM, Arribas-Blazquez M, Sanz-Rodriguez A, Concannon C, Olivos-Ore LA, Reschke CR, Mooney CM, Mooney C, Lugara E, Morgan J, Langa E, Jimenez-Pacheco A, Silva LF, Mesuret G, Boison D, Miras-Portugal MT, Letavic M, Artalejo AR, Bhattacharya A, Diaz-Hernandez M, Henshall DC, Engel T. .
microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus.
Sci Rep. 2015 Dec 3;5:17486. doi: 10.1038/srep17486.     PMID: 26631939      (Dec 2015)

Engel T, Alves M, Sheedy C, Henshall DC. .
ATPergic signalling during seizures and epilepsy.
Neuropharmacology. 2016 May;104:140-53. doi: 10.1016/j.neuropharm.2015.11.001. Epub 2015 Nov 6.     PMID: 26549853      (Nov 2015)

Eva M. Jimenez-Mateos, Rana Raoof, Hani ElNaggar, Norman Delanty, Robert J. Forster and David C. Henshall .
Direct, non-amplified detection of microRNA-134 in plasma from epilepsy patients
RSC Adv., 2015,5, 90071-90078 DOI: 10.1039/C5RA16352H     PMID: n/a      (Oct 2015)

Henshall DC, Kobow K .
Epigenetics and Epilepsy.
Cold Spring Harb Perspect Med. 2015 Oct 5;5(12). pii: a022731. doi: 10.1101/cshperspect.a022731.     PMID: 26438606      (Oct 2015)

Rodriguez-Alvarez N, Jimenez-Mateos EM, Dunleavy M, Waddington JL, Boylan GB, Henshall DC. .
Effects of hypoxia-induced neonatal seizures on acute hippocampal injury and later-life seizure susceptibility and anxiety-related behavior in mice
Neurobiol Dis. 2015 Nov;83:100-14. doi: 10.1016/j.nbd.2015.08.023. Epub 2015 Sep 1.     PMID: 26341542      (Sep 2015)

Diviney M, Reynolds JP, Henshall DC .
Comparison of short-term effects of midazolam and lorazepam in the intra-amygdala kainic acid model of status epilepticus in mice.
Epilepsy Behav. 2015 Oct;51:191-8. doi: 10.1016/j.yebeh.2015.07.038. Epub 2015 Aug 24     PMID: 26291773      (Aug 2015)

Reschke CR1, Henshall DC2 .
microRNA and Epilepsy.
Adv Exp Med Biol. 2015;888:41-70. doi: 10.1007/978-3-319-22671-2_4.     PMID: 26663178      (Jun 2015)

Henshall DC, Engel T .
P2X purinoceptors as a link between hyperexcitability and neuroinflammation in status epilepticus.
Epilepsy Behav. 2015 Aug;49:8-12. doi: 10.1016/j.yebeh.2015.02.031. Epub 2015 Apr 3.     PMID: 25843343      (Apr 2015)

Reynolds JP, Miller-Delaney SF, Jimenez-Mateos EM, Sano T, McKiernan RC, Simon RP, Henshall DC .
Transcriptional Response of Polycomb Group Genes to Status Epilepticus in Mice is Modified by Prior Exposure to Epileptic Preconditioning
Front Neurol. 2015 Mar 10;6:46. doi: 10.3389/fneur.2015.00046. eCollection 2015.     PMID: 25806020      (Mar 2015)

Miller-Delaney SF, Bryan K, Das S, McKiernan RC, Bray IM, Reynolds JP, Gwinn R, Stallings RL, Henshall DC. .
Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy.
Brain. 2015 Mar;138(Pt 3):616-31. doi: 10.1093/brain/awu373. Epub 2014 Dec 30.     PMID: 25552301      (Mar 2015)

Brennan GP, Jimenez-Mateos EM, Sanz-Rodriguez A, Mooney CM, Tzivion G, Henshall DC, Engel T. .
Overexpression of 14-3-3ζ Increases Brain Levels of C/EBP Homologous Protein CHOP.
J Mol Neurosci. 2015 Jun;56(2):255-62. doi: 10.1007/s12031-015-0510-0. Epub 2015 Feb 1     PMID: 25854777      (Feb 2015)

D'Orsi B, Kilbride SM, Chen G, Perez Alvarez S, Bonner HP, Pfeiffer S, Plesnila N, Engel T, Henshall DC, Düssmann H, Prehn JH .
Bax regulates neuronal Ca2+ homeostasis
J Neurosci. 2015 Jan 28;35(4):1706-22. doi: 10.1523/JNEUROSCI.2453-14.2015.     PMID: 25632145      (Jan 2015)

Dávila D., Jiménez-Mateos E.M., Mooney C.M., Velasco G., Henshall D.C., Prehn J.H. .
Hsp27 binding to the 3'UTR of bim mRNA prevents neuronal death during oxidative stress-induced injury - a novel cytoprotective mechanism.
Mol Biol Cell. 2014     PMID: 25187648      (Sep 2014)

Jimenez-Mateos E.M., Engel T., Merino-Serrais P., Fernaud-Espinosa I., Rodriguez N., Reynolds J., Reschke C.R., Conroy R.M., McKiernan R.C., DeFelipe J., Henshall D.C. .
Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus.
Brain Struc Func (2014)     PMID: 24874920      (May 2014)

Mesuret G., Engel T., Hessel E.V., Sanz-Rodriguez A., Jimenez-Pacheco A., Miras-Portugal M.T., Diaz-Hernandez M., Henshall D.C. .
P2X7 receptor inhibition interrupts the progression of seizures in immature rats and reduces hippocampal damage.
CNS Neuroscience & Therapeutics 20, 556-564 (2014)     PMID: 24750893      (Apr 2014)

Nolan K., Poeschel S., Mitchum M.K., Jimenez-Mateos E.M., Henshall D.C., Concannon C.G., Prehn J.H.M. .
Increased expression of microRNA-29a in ALS mice: functional analysis of its inhibition.
J Mol Neurosci 53, 231-241 (2014)     PMID: 24696165      (Apr 2014)

Henshall D.C. .
MicroRNA and epilepsy: Profiling, functions and potential clinical applications
Curr Opinion Neurol 27, 199-205     PMID: 24553459      (Apr 2014)

Henshall D.C., Diaz-Hernandez M., Miras-Portugal M.T., Engel T. .
P2X receptors as targets for the treatment of status epilepticus.
Front Cell Neurosci 7, ar237, 1-10 (2013).     PMID: n/a      (Nov 2013)

Henshall D.C. .
MicroRNAs in the pathophysiology and treatment of status epilepticus
Front Mol Neurosci 6, ar37, 1-11 (2013).     PMID: n/a      (Nov 2013)

Jimenez-Pacheco A., Mesuret G., Sanz-Rodriguez A., Tanaka K., Mooney C., Conroy R., Miras-Portugal M.T., Diaz-Hernandez M., Henshall D.C., Engel T. .
. Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079.
Epilepsia 54, 1551-1561 (2013)     PMID: n/a      (Oct 2013)

Henshall D.C., Engel T., .
Contribution of Apoptosis-Associated Signaling Pathways to Epileptogenesis: Lessons from Bcl-2 Family Knockouts
Front. Cell. Neurosci. 7, ar110, 1-11 (2013)     PMID: n/a      (Sep 2013)

Moran C., Sanz-Rodriguez A., Jimenez-Pacheco A., Martinez-Villareal J., McKiernan R.C., Jimenez-Mateos E.M., Mooney C., Woods I., Prehn J.H., Henshall D.C., Engel T. .
Bmf up-regulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death death.
Cell Death Dis. 4, e606 (2013).     PMID: n/a      (Jul 2013)

Henshall D.C. .
Antagomirs and microRNA in status epilepticus
Epilepsia 54(suppl 6), 17-19 (2013).     PMID: doi: 10.1111/epi.12267      (Jul 2013)

Caballero-Caballero A, Engel, T, de Villarreal Chico JM, Sanz-Rodriguez A., Chang P, Dunleavy M, Mooney M. C., Jimenez-Mateos E.M., Schindler C, Henshall D.C .
Mitochondrial localization of the Forkhead box class O transcription factor in FOXO3a in brain.
J Neurochem 124, 749-756 (2013)     PMID: n/a      (May 2013)

Torres-Peraza JF, Engel T, Martin-Ibanez R, Fernandez-Fernandez MR, Esgleas M, Canals JM, Henshall DC, Lucas JJ. .
Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus
Brain 136, 1161-1176 (2013).     PMID: doi:10.1093/brain/awt044      (May 2013)

Jimenez-Mateos E.M. and Henshall D.C. .
Epilepsy and microRNA
Neuroscience 238, 218-229 (2013)     PMID: n/a      (Apr 2013)

Engel T., Sanz-Rodgriguez A., Jimenez-Mateos E.M., Concannon C., Jimenez-Pacheco A., Moran C., Mesuret G., Delanty N., Farrell M., O’Brien D., Prehn J.H., Lucas, J.J. Henshall D.C .
CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures.
Brain 136, 577-592 (2013)     PMID: doi:10.1093/brain/aws337      (Apr 2013)

Brennan G., Jimenez-Mateos M.E., McKiernan R.C., Engel T., Tzivion G., Henshall D.C. .
Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo.
PLoS One 8:e54491 (2013)     PMID: n/a      (Apr 2013)

Dunleavy M., Provenzano G., Henshall D.C., Bozzi Y .
Kainic acid-induced seizures modulate Akt (Ser473) phosphorylation in the hippocampus of dopamine D2 receptor knockout mice
J Mol Neurosci 49, 202-210 (2013)     PMID: DOI 10.1007/s12031-012-9927-x      (Jan 2013)

Engel T., Jimenez-Pacheco A., Miras-Portugal M.T., Diaz-Hernandez M., Henshall D.C. .
P2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control.
Int J Phys Pathophys Pharm 4, 174-187 (2012)     PMID: n/a      (Dec 2012)

Michalak Z., Sano T., Engel T., Miller-Delaney S.F., Lerner-Natoli M., Henshall D.C. .
Spatio-temporally restricted blood-brain barrier disruption after intra-amygdala kainic acid-induced status epilepticus in mice
Epilepsy Res. 2012 (in press)     PMID: 23182415      (Nov 2012)

Heverin M. Engel T., Meany S., Jimenez-Mateos E., Al-Saud R., Henshall D.C. .
Bi-lateral changes to hippocampal cholesterol levels during epileptogenesis and in chronic epilepsy following focal-onset status epilepticus in mice.
Brain Res 1480:81-90 (2012)     PMID: 22921849      (Aug 2012)

McKiernan R.C., Jimenez-Mateos E.M., Sano T., Bray I., Stallings R.L., Simon R.P. Henshall D.C. .
Expression profiling the microRNA response to epileptic preconditioning identifies miR-184 as a modulator of seizure-induced neuronal death
Exp Neurol 237:346-54 (2012)     PMID: 22771761      (Jul 2012)

Michalak Z., Lebrun A., diMiceli M., Rousset M.C., de Bock F., Crespel A., Coubes P., Henshall D.C., Lerner-Natoli M., Rigau V. .
IgG leakage may contribute to neuronal dysfunction in drug-refractory epilepsies with blood-brain barrier disruption.
J. Neuropathol. Exp. Neurol. 71:826-838 (2012)     PMID: N/A      (Jul 2012)

Heverin M., Brennan G., Koehler C., Treumann A., Henshall D.C. .
Proteomic analysis of 14-3-3 zeta binding proteins in the mouse hippocampus
Int J Physiol Pathophysiol Pharm 4:74-83 (2012)     PMID: 22837806      (Jun 2012)

Jimenez-Mateos E.M., Engel T., Merino-Serrais P., McKiernan R.C., Tanaka K., Mouri G., Sano T., Prenter S., O’Tuathaigh C., Waddington J.L., Delanty N., Farrell M.A., O’Brien D.F., Stallings R.L., deFelipe J., Henshall D.C. .
Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects.
Nat Med 18: 1087-1093 (2012)     PMID: 22683779      (Jun 2012)

McKiernan R.C., Jimenez-Mateos E.M., Bray I., Engel T., Sano T., Delanty N., Farrell M.A., O’Brien D.F., Meller R., Simon R.P., Stallings R.L., Henshall D.C. .
Reduced mature microRNA levels in association with Dicer loss in human temporal lobe epilepsy with hippocampal sclerosis.
PLoS One 7, e35921 (2012)     PMID: 22615744      (May 2012)

Sano T., Reynolds J., Jimenez E.M., Matsushima S., Taki W., Henshall D.C. .
MicroRNA-34a up-regulation during seizure-induced neuronal death.
Cell Death Dis. 3, e287 (2012)     PMID: 22436728      (Mar 2012)

Kilany A., Raouf E.R.A., Gaber A.A., Aloush T.A., Aref H.A., Anwar M., Henshall D.C., Abdulghani M.A. .
Elevated serum Bcl-2 in children with temporal lobe epilepsy.
Seizure 21, 250-253 (2012)     PMID: 22365585      (Mar 2012)

Miller-Delaney S., Das S., Sano T., Jimenez-Mateos, E.M., Bryan K., Buckley P, Stallings R.L., Henshall D.C. .
Differential DNA methylation patterns define status epilepticus and epileptic tolerance.
J. Neurosci. 32, 1577-1588 (2012)     PMID: 22302800      (Mar 2012)

Engel T., Gomez-Villafuertes R., Tanaka K., Mesuret G., Sanz-Rodriguez A., Garcia-Huerta P., Miras-Portugal M.T., Henshall D.C., Diaz-Hernandez M. .
Seizure suppression and neuroprotection during status epilepticus by targeting the purinergic P2X7 receptor in mice.
FASEB J 26, 1616-1628 (2012)     PMID: 22198387      (Dec 2011)

Rünker A.E., O'Tuathaigh C., Dunleavy, M., Morris D.W., Little G.E., Corvin, A.P., Gill M., Henshall D.C., Waddington J.L., Mitchell K.J. .
Mutation of Semaphorin-6A disrupts limbic and cortical connectivity and models neurodevelopmental psychopathology
PLoS One, 6, e26488 (2011)     PMID: 22132072      (Nov 2011)

Jimenez-Mateos E.M., Bray I., McKiernan R.C., Engel T., Mouri G., Tanaka K., Saugstad J.A., Simon R.P., Stallings R.L. Henshall D.C. .
MicroRNA expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132.
Am J Pathol 179, 2519-2532 (2011)     PMID: 21945804      (Nov 2011)

Simon R.P., Meller R., Zhou A., Henshall D.C. .
Can genes modify stroke and by what mechanisms?
Stroke 43, 286-291 (2012)     PMID: 22156698      (Sep 2011)

Bozzi Y., Dunleavy M., Henshall D.C. .
Cell signaling underlying epileptic behavior.
Front. Behav. Neurosci. 5, 45 (2011)     PMID: 21852968      (Aug 2011)

Thompson S.J., Ashley M.D., Stöhr S., Schindler C.K., Li M., McCarthy K.A. Pearson A.N., Xiong Z.G., Simon R.P., Henshall D.C., Meller R. .
Suppression of TNF receptor-1 signaling in an in vitro model of epileptic tolerance
Int J Physiol, Pathophysiol & Pharm 3, 120-132 (2011)     PMID: 21760970      (May 2011)

Gangarossa G., Di Benedetto M., O'Sullivan G.J., Dunleavy M., Alcacer C., Bonito-Oliva A., Henshall D.C., Waddington J.L., Valjent E., Fisone G. .
Convulsant doses of a dopamine D1 receptor agonist result in ERK-depdent increases in Zif268 and Arc/Arg3.1 expression in mouse dentate gyrus
PLoS One 6, e19415 (2011)     PMID: 21559295      (May 2011)

Thompson S., Ordonez A., Ashley M., Jessick V., Murphy B.M., Gafken P., Henshall D.C., Morris K., Simon R.P., Meller R. .
Identification of a novel Bim E3 ligase, tri-partite motif containing protein 2, and its role in rapid ischemic tolerance-induced neuroprotection.
J. Biol. Chem. 286, 19331-9 (2011)     PMID: 21478148      (Apr 2011)

Engel T., Plesnila N., Prehn J.H., Henshall D.C. .
In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia and traumatic brain injury.
J. Cereb. Blood Flow Metab. 31:1196-210     PMID: 21364604      (Mar 2011)

Bunk E.C, König H.G, Bernas T., Engel T., Henshall, D.C., Kirby B.P., Prehn J.H.M. .
BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus.
Cell Death Dis. 1, doi:10.1038/cddis.2009.13 (2010)     PMID: 21364616      (Feb 2011)

Tsuchiya T., Bonner H.P., Engel T., Woods I., Matsushima S., Ward M.W., Taki W., Henshall D.C., Concannon C.G., Prehn J.H. .
BH3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo.
Eur. J. Neurosci. 2011 33, 401-8.     PMID: 21198986      (Feb 2011)

Engel T., Schindler C.K., Sanz-Rodriguez A., Conroy R., Meller R., Simon R.P. Henshall D.C. .
Expression of neurogenesis genes in human temporal lobe epilepsy with hippocampal sclerosis.
Int J Physiol, Pathophysiol & Pharm 3, 38-47 (2011)     PMID: 21479101      (Jan 2011)

Engel T., Tanaka K., Jimenez-Mateos E.M., Caballero-Caballero A., Prehn J.H., Henshall D.C. .
Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus.
Cell Death Dis. 1, e79; doi:10.1038/cddis.2010.55     PMID: 21368852      (Oct 2010)

Engel T., Caballero-Caballero A., Schindler C.K., Plesnila N., Strasser A., Prehn J.H., Henshall D.C. .
The BH3-only protein Bid is dispensable for seizure-induced neuronal death and the associated nuclear accumulation of apoptosis-inducing factor (AIF).
J. Neurochem. 115, 92-101 (2010)     PMID: 20646170      (Jul 2010)

Engel T., Hatazaki S., Tanaka K., Prehn J.H., Henshall D.C. .
Deletion of puma protects hippocampal neurons in a model of severe status epilepticus.
Neuroscience 168, 443-450 (2010).     PMID: 20362645      (Apr 2010)

Engel T, Murphy BM, Hatazaki S, Jimenez-Mateos EM, Concannon CG, Woods I, Prehn JH, Henshall DC .
Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma
FASEB Journal 24, 853-861 (2010)     PMID: 19890018      (Mar 2010)

Jimenez-Mateos E.J., Mouri G., Conroy R., Henshall D.C. .
Epileptic tolerance is associated with enduring neuroprotection and uncoupling of the relationship between CA3 damage, neuropeptide Y rearrangement and spontaneous seizures following intra-amygdala kainic acid-induced status epilepticus in mice.
Neuroscience 171, 556-565     PMID: 20837105      (Jan 2010)

Henshall D.C., Meldrum B.S. .
Cell death after single and repeated brief seizures.
Epilepsia 51, (suppl. 5) p35 (2010)     PMID: Not yet available      (Jan 2010)

Dunleavy M, Shinoda S, Schindler C, Ewart C, Dolan R, Gobbo OL, Kerskens CM, Henshall DC. .
Experimental neonatal status epilepticus and the development of temporal lobe epilepsy with unilateral hippocampal sclerosis.
Am J Pathol 176, 330-342 (2010)     PMID: 19948825      (Dec 2009)

Tanaka K, Jimenez-Mateos E, Matsushima S, Taki W, Henshall DC. .
Hippocampal damage after intra-amygdala kainic acid-induced status epilepticus and seizure preconditioning-mediated neuroprotection in SJL mice.
Epilepsy Res 88, 151-161 (2010)     PMID: 19931419      (Nov 2009)

Murphy B.M., Engel T., Paucard A., Hatazaki S., Mouri G., Tanaka K., Tuffy L.P., Jimenez-Mateos E., Woods I., Dunleavy M., Bonner H.P., Meller R., Simon R.P., Strasser A., Prehn J.H., Henshall D.C. .
Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex following status epilepticus
Cell Death Differ 17, 459-468 (2010)     PMID: 19779495      (Sep 2009)

Henshall DC, Dürmüller N, White HS, Williams R, Moser P, Dunleavy M, Silverstone PH .
Electroencephalographic and behavioral convulsant effects of hydrobromide and hydrochloride salts of bupropion in conscious rodents.
Neuropsychiatr Dis Treat 5, 189-206 2009     PMID: 19557114      (Apr 2009)

Kuroki K., Virard I., Concannon C.G., Engel T., Woods I, Taki W., Plesnila N., Henshall D.C., Prehn J.H. .
Effects of transient focal cerebral ischemia in mice deficient in puma
Neurosci Lett (2009) 451: 237-40     PMID: 19159665      (Jan 2009)

Engel T., and Henshall D.C. .
Apoptosis, Bcl-2 family proteins and Caspases: the ABCs of seizure-damage and epileptogenesis?
Int J Physiol, Pathophysiol & Pharm 1, 97-115 (2009)     PMID: Not yet available      (Jan 2009)

Jimenez-Mateos, E. and Henshall D.C. .
Seizure preconditioning and epileptic tolerance: models and mechanisms
Int J Physiol, Pathophysiol & Pharm 1, 180-191 (2009)     PMID: Not yet available      (Jan 2009)

Jimenez-Mateos EM, Hatazaki S, Johnson MB, Bellver-Estelles C, Mouri G, Bonner C, Prehn JH, Meller R, Simon RP, Henshall DC. .
Hippocampal transcriptome after status epilepticus in mice rendered seizure damage-tolerant by epileptic preconditioning features suppressed calcium and neuronal excitability pathways.
Neurobiol Dis (2008) 32, 442-453     PMID: 18804535      (Sep 2008)

Murphy N, Yamamoto A, Henshall DC. .
Detection of 14-3-3zeta in cerebrospinal fluid following experimentally evoked seizures.
Biomarkers. 13:377-84     PMID: 18484353      (Jul 2008)

Murphy N, Bonner HP, Ward MW, Murphy BM, Prehn JH, Henshall DC. .
Depletion of 14-3-3 zeta elicits endoplasmic reticulum stress and cell death, and increases vulnerability to kainate-induced injury in mouse hippocampal cultures.
J Neurochem. 2008 106, 978-988     PMID: 18466333      (May 2008)

Mouri G, Jimenez-Mateos E, Engel T, Dunleavy M, Hatazaki S, Paucard A, Matsushima S, Taki W, Henshall DC .
Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice
Brain Res. 2008 1213, 140-151     PMID: 18455706      (Apr 2008)

O'Sullivan GJ, Dunleavy M, Hakansson K, Clementi M, Kinsella A, Croke DT, Drago J, Fienberg AA, Greengard P, Sibley DR, Fisone G, Henshall DC, Waddington JL .
Dopamine D(1) vs D(5) receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling.
Neuropharmacology 54:1051-61     PMID: 18367215      (Feb 2008)

Meller R, Torrey DJ, Thompson SJ, Ordonez AN, Ashley MD, Wang W, Henshall DC, Gafken P, Lusardi TA, Saugstad JA, Xiong ZG and Simon RP. .
Synaptic structural reorganization - a novel mechanism underlying rapid ischemic tolerance.
J. Neurosci. 28, 50-59     PMID: 18171922      (Jan 2008)

Henshall DC and Murphy B. .
Modulators of neuronal cell death in epilepsy
Curr Opinion Pharmacol 8:75-81.     PMID: 17827063      (Dec 2007)

Simon R, Henshall D, Stoehr S, Meller R. .
Endogenous mechanisms of neuroprotection
Epilepsia 2007 48 (s8) 72-73     PMID: 18330006      (Dec 2007)

Concannon C, Ward MW, Bonner HP, Kuroki K, Tuffy LP, Bonner CT, Woods I, Engel T, Henshall DC, Prehn JH. .
NMDA receptor-mediated excitotoxic neuronal injury in vitro and in vivo occurs in an ER Stress and PUMA independent manner
J Neurochem 105:891-903     PMID: 18088354      (Nov 2007)

Simon R, Henshall D, Stohr S and Meller R. .
Endogenous mechanisms of neuroprotection
Epilepsia 48 Suppl 8:72-3.     PMID: 18312252      (Nov 2007)

Murphy B, Dunleavy M, Shinoda S, Schindler CK, Meller R, Bellver-Estelles C, Hatazaki S, Dicker P, Yamamoto A, Koegel I, Prehn JH, Simon RP and Henshall DC .
Bcl-w protects hippocampus during experimental status epilepticus.
Am J Pathol 171:1258-68     PMID: 17702891      (Oct 2007)

Engel T, Murphy BM, Schindler CK, Henshall DC .
Elevated p53 and lower MDM2 expression in hippocampus from patients with intractable temporal lobe epilepsy
Epilepsy Res. 77:151-6.     PMID: 17942278      (Oct 2007)

Hatazaki S, Bellver-Estelles C, Jimenez-Mateos E, Meller R, Bonner C, Murphy N, Matsushima S, Taki W, Prehn J, Simon RP, Henshall DC .
Microarray profile of seizure damage-refractory hippocampal CA3 in a mouse model of epileptic preconditioning.
Neuroscience 150:467-77     PMID: 17935890      (Sep 2007)

Henshall DC .
Apoptosis signalling pathways in seizure-induced neuronal death and epilepsy.
Biochem Soc. Proc. 35(2), 421-423     PMID: 17371290      (Apr 2007)

Rosenzweig HL, Minami M, Lessov NS, Coste S, Stevens SL, Henshall DC, Meller R, Simon RP and Stenzel-Poore MP. .
Endotoxin preconditioning protects against the cytotoxic effects of TNFalpha following stroke: A novel role for TNFalpha in LPS-ischemic tolerance.
J. Cereb Blood Flow Metab. 27:1663-74.     PMID: 17327883      (Feb 2007)

Yamamoto A, Schindler CK, Murphy BM, Bellver-Estelles C, So NK, Taki W, Meller R, Simon RP, Henshall DC. .
Evidence of tumor necrosis factor receptor 1 signaling in human temporal lobe epilepsy
Exp Neurol. 202, 41-420     PMID: 16919273      (Dec 2006)

Schindler CK, Heverin M, Henshall DC. .
Isoform- and subcellular fraction-specific differences in hippocampal 14-3-3 levels following experimentally evoked seizures and in human temporal lobe epilepsy.
J. Neurochem. 99, 561-569     PMID: 16981892      (Oct 2006)

Meller R, Clayton C, Torrey D, Schindler CK, Lan JQ, Cameron J, Chu XP, Xiong ZG, Simon RP, Henshall DC. .
Activation of the caspase 8 pathway mediates seizure-induced cell death in cultured hippocampal neurons.
Epilepsy Res. 70(1):3-14     PMID: 16542823      (Jul 2006)

Yamamoto A, Murphy N, Schindler CK, So NK, Stohr S, Taki W, Prehn JH and Henshall DC. .
Endoplasmic reticulum stress and apoptosis signaling in human temporal lobe epilepsy.
J. Neuropathol. Exp. Neurol. 65(3):217-25     PMID: 16651883      (Mar 2006)

Meller R, Cameron JA, Torrey DJ, Clayton CE, Ordonez AN, Henshall DC, Minami M, Schindler CK, Saugstad JA and Simon RP. .
Rapid degradation of bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultures neurons.
J Biol Chem;281(11):7429-36     PMID: 16431916      (Jan 2006)

Henshall DC, Simon RP .
Epilepsy and apoptosis pathways.
J Cereb Blood Flow Metab; 25(12):1557-1572     PMID: 15889042      (Dec 2005)

Schindler CK, Pearson EG, Bonner HP, So NK, Simon RP, Prehn JH, Henshall DC .
Caspase-3 cleavage and nuclear localization of caspase-activated DNase in human temporal lobe epilepsy.
J Cereb Blood Flow Metab;26(4):583-9     PMID: 16121124      (Aug 2005)

Meller R, Minami M, Cameron JA, Impey S, Chen D, Lan JQ, Henshall DC, Simon RP .
CREB-mediated Bcl-2 protein expression after ischemic preconditioning.
J Cereb Blood Flow Metab;25(2):234-46     PMID: 15647742      (Feb 2005)

Rosenzweig HL, Lessov NS, Henshall DC, Minami M, Simon RP, Stenzel-Poore MP .
Endotoxin preconditioning prevents cellular inflammatory response during ischemic neuroprotection in mice.
Stroke;35(11):2576-81     PMID: 15375302      (Nov 2004)

Henshall DC, Schindler CK, So NK, Lan JQ, Meller R, Simon RP .
Death-associated protein kinase expression in human temporal lobe epilepsy.
Ann Neurol;55(4):485-94     PMID: 15048887      (Apr 2004)

Shinoda S, Araki T, Lan JQ, Schindler CK, Simon RP, Taki W, Henshall DC .
Development of a model of seizure-induced hippocampal injury with features of programmed cell death in the BALB/c mouse.
J Neurosci Res;76(1):121-8     PMID: 15048936      (Apr 2004)

Shinoda S, Schindler CK, Meller R, So NK, Araki T, Yamamoto A, Lan JQ, Taki W, Simon RP, Henshall DC .
Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy.
J Clin Invest;113(7):1059-68     PMID: 15057313      (Apr 2004)

Schindler CK, Shinoda S, Simon RP, Henshall DC .
Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat.
Neurosci Lett;356(3):163-6     PMID: 15036620      (Feb 2004)

Araki T, Shinoda S, Schindler CK, Quan-Lan J, Meller R, Taki W, Simon RP, Henshall DC .
Expression, interaction, and proteolysis of death-associated protein kinase and p53 within vulnerable and resistant hippocampal subfields following seizures.
Hippocampus;14(3):326-36     PMID: 15132432      (Jan 2004)

Jin K, Peel AL, Mao XO, Xie L, Cottrell BA, Henshall DC, Greenberg DA .
Increased hippocampal neurogenesis in Alzheimer's disease.
Proc Natl Acad Sci U S A;101(1):343-7     PMID: 14660786      (Jan 2004)

Henshall DC, Araki T, Schindler CK, Shinoda S, Lan JQ, Simon RP .
Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures.
J Neurochem;86(5):1260-70     PMID: 12911633      (Sep 2003)

Shinoda S, Schindler CK, Quan-Lan J, Saugstad JA, Taki W, Simon RP, Henshall DC .
Interaction of 14-3-3 with Bid during seizure-induced neuronal death.
J Neurochem;86(2):460-9     PMID: 12871587      (Jul 2003)

Shinoda S, Skradski SL, Araki T, Schindler CK, Meller R, Lan JQ, Taki W, Simon RP, Henshall DC .
Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death.
Eur J Neurosci;17(10):2065-76     PMID: 12786973      (May 2003)

Meller R, Schindler CK, Chu XP, Xiong ZG, Cameron JA, Simon RP, Henshall DC .
Seizure-like activity leads to the release of BAD from 14-3-3 protein and cell death in hippocampal neurons in vitro.
Cell Death Differ;10(5):539-47     PMID: 12728252      (May 2003)

Liou AK, Clark RS, Henshall DC, Yin XM, Chen J .
To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways.
Prog Neurobiol;69(2):103-42     PMID: 12684068      (Feb 2003)

Chen D, Minami M, Henshall DC, Meller R, Kisby G, Simon RP .
Upregulation of mitochondrial base-excision repair capability within rat brain after brief ischemia.
J Cereb Blood Flow Metab;23(1):88-98     PMID: 12500094      (Jan 2003)

Henshall DC, Araki T, Schindler CK, Lan JQ, Tiekoter KL, Taki W, Simon RP .
Activation of Bcl-2-associated death protein and counter-response of Akt within cell populations during seizure-induced neuronal death.
J Neurosci;22(19):8458-65     PMID: 12351720      (Oct 2002)

Araki T, Simon RP, Taki W, Lan JQ, Henshall DC .
Characterization of neuronal death induced by focally evoked limbic seizures in the C57BL/6 mouse.
J Neurosci Res;69(5):614-21     PMID: 12210827      (Sep 2002)

Henshall DC, Skradski SL, Meller R, Araki T, Minami M, Schindler CK, Lan JQ, Bonislawski DP, Simon RP .
Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures.
Neurobiol Dis;10(2):71-87     PMID: 12127146      (Jul 2002)

Meller R, Skradski SL, Simon RP, Henshall DC .
Expression, proteolysis and activation of caspases 6 and 7 during rat C6 glioma cell apoptosis.
Neurosci Lett;324(1):33-6     PMID: 11983288      (May 2002)

Henshall DC, Bonislawski DP, Skradski SL, Araki T, Lan JQ, Schindler CK, Meller R, Simon RP .
Formation of the Apaf-1/cytochrome c complex precedes activation of caspase-9 during seizure-induced neuronal death.
Cell Death Differ;8(12):1169-81     PMID: 11753565      (Dec 2001)

Henshall DC, Bonislawski DP, Skradski SL, Lan JQ, Meller R, Simon RP .
Cleavage of bid may amplify caspase-8-induced neuronal death following focally evoked limbic seizures.
Neurobiol Dis;8(4):568-80     PMID: 11493022      (Aug 2001)

Henshall DC, Skradski SL, Lan JQ, Ren T, Simon RP .
Increased Bcl-w expression following focally evoked limbic seizures in the rat.
Neurosci Lett;305(3):153-6     PMID: 11403928      (Jun 2001)

Henshall DC, Skradski SL, Bonislawski DP, Lan JQ, Simon RP .
Caspase-2 activation is redundant during seizure-induced neuronal death.
J Neurochem;77(3):886-95     PMID: 11331417      (May 2001)

Nagayama T, Lan J, Henshall DC, Chen D, O'Horo C, Simon RP, Chen J .
Induction of oxidative DNA damage in the peri-infarct region after permanent focal cerebral ischemia.
J Neurochem;75(4):1716-28     PMID: 10987855      (Oct 2000)

Henshall DC, Clark RS, Adelson PD, Chen M, Watkins SC, Simon RP .
Alterations in bcl-2 and caspase gene family protein expression in human temporal lobe epilepsy.
Neurology;55(2):250-7     PMID: 10908900      (Jul 2000)

Nagayama T, Simon RP, Chen D, Henshall DC, Pei W, Stetler RA, Chen J .
Activation of poly(ADP-ribose) polymerase in the rat hippocampus may contribute to cellular recovery following sublethal transient global ischemia.
J Neurochem;74(4):1636-45     PMID: 10737622      (Apr 2000)

Henshall DC, Chen J, Simon RP .
Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures.
J Neurochem;74(3):1215-23     PMID: 10693954      (Mar 2000)

Henshall DC, Sinclair J, Simon RP .
Spatio-temporal profile of DNA fragmentation and its relationship to patterns of epileptiform activity following focally evoked limbic seizures.
Brain Res;858(2):290-302     PMID: 10708680      (Mar 2000)

Minami M, Jin KL, Li W, Nagayama T, Henshall DC, Simon RP .
Bcl-w expression is increased in brain regions affected by focal cerebral ischemia in the rat.
Neurosci Lett;279(3):193-5     PMID: 10688062      (Feb 2000)

Lan J, Henshall DC, Simon RP, Chen J .
Formation of the base modification 8-hydroxyl-2'-deoxyguanosine and DNA fragmentation following seizures induced by systemic kainic acid in the rat.
J Neurochem;74(1):302-9     PMID: 10617133      (Jan 2000)

Henshall DC, Sinclair J, Simon RP .
Relationship between seizure-induced transcription of the DNA damage-inducible gene GADD45, DNA fragmentation, and neuronal death in focally evoked limbic epilepsy.
J Neurochem;73(4):1573-83     PMID: 10501203      (Oct 1999)

Henshall DC, Butcher SP, Sharkey J .
A rat model of endothelin-3-induced middle cerebral artery occlusion with controlled reperfusion.
Brain Res;843(1-2):105-11     PMID: 10528116      (Oct 1999)

Kawaguchi K, Henshall DC, Simon RP .
Parallel dose-response studies of the voltage-dependent Na+ channel antagonist BW619C89, and the voltage-dependent Ca2+ channel antagonist nimodipine, in rat transient focal cerebral ischaemia.
Eur J Pharmacol;364(2-3):99-105     PMID: 9932711      (Jan 1999)

Tanaka K, Henshall DC, Waga S, Shimosaka S, Simon RP .
Bilateral intranigral NMDA infusion suppresses neuronal injury without affecting the duration of kainic acid-induced seizures in rats.
Neurosci Lett;251(1):69-71     PMID: 9714467      (Jul 1998)

Butcher SP, Henshall DC, Teramura Y, Iwasaki K, Sharkey J. .
Neuroprotective actions of FK506 in experimental stroke: in vivo evidence against an antiexcitotoxic mechanism.
J Neurosci;17(18):6939-46     PMID: 9278529      (Sep 1997)