FERGAL O'BRIEN: Curriculum Vitae
contact details

Professor
Anatomy, RCSI

123 St Stephens Green, Dublin 2
fjobrien@rcsi.ie
Telephone: 01 4022149
Mobile: 0866849901
Fax: 01 4022355

Department Secretary: Amanda Campbell
Email: amandacampbell@rcsi.ie
Telephone: 01 402 2260

appointments

2013 to date: Professor of Bioengineering & Regenerative Medicine, RCSI

2013 to date: Honorary Clinical Tutor, University of Edinburgh School of Medicine & Veterinary Medicine

2013 to date: Principal Investigator and Deputy Director, Advanced Materials and BioEngineering Research (AMBER) Centre

2013 to date: Deputy Director for Research (Applied Research), RCSI

2009 to date: Adjunct Professor in Bioengineering, Trinity College Dublin

2004 to 2009: Lecturer in Biomechanical Engineering (part time), Trinity College Dublin

2003 to 2006: Lecturer in Anatomy, RCSI

2003 to date: Principal Investigator, Trinity Centre for Bioengineering

2001 to 2003: Postdoctoral Research Associate/ Fulbright Scholar, Massachusetts Institute of Technology, Cambridge, MA, USA

2000 to 2001: Postdoctoral Research Fellow, TCD/RCSI

academic activity

1. Joint Editor of Proceedings of 5th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine of Ireland

2. Subject Editor (Tissue Engineering) for the Journal of the Mechanical Behavior of Biomedical Materials

3. Guest Editor of a Special Issue of Technology and Healthcare ‘Tissue Engineering for Orthopaedic Applications

4. Editor of ESEM News, the Newsletter of the European Society for Engineering and Medicine. 2004- 2006.

5. Editor of the Official Website of the European Society for Engineering and Medicine. 2004- present..

6. Executive Board Member, European Society for Engineering and Medicine

7. Council Member, European Society for Engineering and Medicine

8. Committee Member, Biomedical Devision, Engineers Ireland

9. Editorial Board Member, Frontiers in Bioengineering and Biotechnology

10. Editorial Board Member, Bioengineering

11. European Council Member, Tissue Engineering & Regenerative Medicine International Society

12. Editorial Board Member, BioNano Materials

summary of research career to date

Prof. Fergal O'Brien is Professor of Bioengineering & Regenerative Medicine, Deputy Director of Research and Head of Tissue Engineering Research Group in RCSI which is one of the largest advanced biomaterials and tissue engineering/regenerative medicine research groups in Ireland. Following a degree in mechanical engineering and PhD in bone mechanobiology, Prof. O'Brien was a Fulbright Scholar in tissue engineering at Massachusetts Institute of Technology and Harvard Medical School. Since his faculty appointment in 2003, he has published almost 200 journal articles in leading peer-reviewed international journals, filed 13 patents/disclosures and supervised over 30 doctoral students to completion. He has a current h-index of 55 (Oct, 2017). He is a recipient of two prestigious European Research Council Awards. Other accolades include a Fulbright Scholarship (2001), New Investigator Recognition Award by the Orthopaedic Research Society (2002), Science Foundation Ireland, President of Ireland Young Researcher Award (€1.1. million, 2004), Anatomical Society New Fellow of the Year (2014) and Fellowship of both Engineers Ireland (2013) and the European Alliance for Medical & Biological Engineering Science (2016). O'Brien is currently a member of the World Council of Biomechanics and immediate-past President of the Section of Bioengineering of the Royal Academy of Medicine in Ireland (2014-16) and has previously served as Biomaterials Topic Chair for the Orthopaedic Research Society, as an EU Council Member of Tissue Engineering and Regenerative Medicine International Society (TERMIS) and a member of Irish Medicines Board Advisory Committee on Medical Devices. He is a co-founder of SurgaColl Technologies, which has translated 2 technologies for bone and cartilage repair from his lab to the clinic. In addition he is an editorial board member of 5 journals and Subject Editor (Tissue Engineering) for the Journal of the Mechanical Behavior of Biomedical Materials. He is also Co-chair of the World Congress of Biomechanics which is being held in Ireland in 2018. He has presented over 100 invited talks including keynotes at leading international conferences and symposia including the International Bone-Tissue Engineering Congress (Bone-TEC), Gordon Musculoskeletal Conference, World Congress of Biomechanics, TERMIS Annual meetings, World Conference on Regenerative Medicine, International Controlled Release Society, and Anatomical Society meetings. He has served as an invited reviewer for more than 100 scientific journals and as a grant reviewer and committee panelist for funding agencies worldwide. https://www.linkedin.com/in/fergal-o-brien-9b065a1/

research interests

The TERG develops natural polymer- (such as collagen) scaffold-based therapeutics for tissue engineering with target applications in bone, cartilage, cardiovascular, corneal, respiratory and neural tissues. A major focus of on-going research has been to functionalise these scaffolds for use as delivery systems for biomolecules with a particular interest in the delivery of nucleic acids (pDNA/siRNA/microRNA) to enhance their therapeutic potential. TERG also focuses on the use of these scaffolds as advanced 3D pathophysiology in vitro systems for drug development and for studying cellular crosstalk and understanding disease states in cancer, angiogenesis, immunology and infection. Prof. O'Brien also has a major interest in studying the response of living cells to mechanical stimuli (mechanobiology) and using biophysical stimuli to regulate stem cell differentiation. A number of technologies from the lab have been patented resulting in the spin out (2011) of a high potential start-up, SurgaColl Technologies. The first product from the group commercialised by SurgaColl, HydroxyColl, a collagen-hydroxyapatite bone graft substitute received regulatory approval (CE mark) in Nov. 2015 and is currently in clinical use. A second product, ChondroColl, a multi-layered scaffold for cartilage repair, is expected to receive regulatory approval in 2017 with human clinical studies expected to commence soon afterwards.

research areas

Bioengineering, Bio-materials, Biomechanics, Bio-reactor technology, Bone and Joint Disease, Tissue Engineering, Immunity, Infection & Inflammation, Orthopedics, Pharmaceutical Sciences

Memberships

Member of the Faculty of 1000 – Musculoskeletal Repair & Regeneration Section (2013)

Fellow of Engineers Ireland (2013)

Fellow of the Anatomical Society (2012)

Section of Bioengineering Committee, Royal Academy of Medicine in Ireland (2012)

Treasurer of Biomedical Division (BED) Committee Engineers Ireland (2010)

Biomedical Division (BED) Committee, Engineers Ireland (2006)

Chartered Engineer, Engineers Ireland (2005)

Member of the American Society for Bone and Mineral Research (2005)

Member of the European Society of Biomechanics (2004)

Editor of ESEM News, the Newsletter of the European Society for Engineering and Medicine (2004-2006)

Editor of the Official Website of the European Society for Engineering and Medicine (2004-2006)

Member of the European Society for Engineering and Medicine (2003)

Member of the Irish Fulbright Alumni Association (2003)

Member of the Anatomical Society of Great Britain and Ireland (2003)

Member of Royal Academy of Medicine in Ireland (2000)

Joint Editor of Proceedings of 5th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine of Ireland (1999)

Member of the Institution of Engineers of Ireland (1998)

Honours/Awards/Achievements

2016: Elected as Fellow of the European Alliance for Medical and Biological Engineering and Science, EAMBES

2016: Appointed by invitation to the Programme Board for the UK Regenerative Medicine Platform (UKRMP)., Medical Research Council (MRC)

2016: Appointed to the Advisory Board of the Aachen-Maastrict Institute for Biobased Materials, Aachen-Maastrict Institute for Biobased Materials

2016: Appointed by Invitation to the Scientific Advisory Board of the 2017 TERMIS EU Conference, Tissue Engineering and Regenerative Medicine International Society European Chapter (TERMIS-EU)

2015: Elected President of the Bioengineering Section of the Royal Academy of Medicine in Ireland 2015-2016, RAMI

2015: Appointed to Scientific Board Bone-Tec, International Bone-Tissue Engineering Congress, Bone-Tec

2014: Awarded the accolade of Fellow of the year by the Anatomical Society, Anatomical Society

2014: Appointed by invitation as member of the Faculty of 1000 (Musculoskeletal Repair & Regeneration Section), RCSI

2014: Awarded the accolade of Fellow of the year by the Anatomical Society based on CV and service to the Society, RCSI

2014: Appointed by invitation as Biomaterials Topic Chair for the Orthopaedic Research Society, Orthopaedic Research Society

2013: Won the bid (as co-chair) to host the World Congress of Biomechanics which will bring over 3500 delegates to Dublin in 2018, World Congress of Biomechanics

2013: Appointed by invitation to the Editorial Board of Bioengineering, Journal of Bioengineering

2013: Elected to the European Council of the Tissue Engineering and Regenerative Medicine International Society (TERMIS-EU)., Tissue Engineering and Regenerative Medicine International Society (TERMIS-EU)

2012: Elected as a Fellow of the Anatomical Society, Anatomical Society

2012: Elected to the committee of the Section of Bioengineering, Royal Academy of Medicine in Ireland

2012: Organised and Edited a Special Issue on Tissue Engineering, Journal of the Mechanical Behavior of Biomedical Materials

2011: Appointed a member of IMB Advisory Committee on Medical Devices by the Minister for Health & Children, Mary Harney, Irish Medicines Board

2011: At the invitation of SFI and the Royal Irish Academy, represented the Irish scientific community at the World Economic Forum's Annual Meeting of the New Champions (‘Summer Davos’) held in Dalian, China, World Economic Forum

2011: Laboratory spin out company, SurgaColl Technologies, won one of the 'Best Emerging Company’ awards at Intertrade Ireland Seedcorn Business Competition., Intertrade Ireland

2010: Elected Treasurer of the Biomedical Engineering Division, Engineers Ireland

2010: Featured as one of ten ‘Rising Stars’ in research by SFI in their report – ‘Celebrating 10 Years of Discovery’., Science Foundation Ireland

2010: Top cited article award 2008-2010, Biochemical & Biophysical Research Communications

2009: Recognised in an article by the Sunday Independent as one of the ‘forty under forty- Whizzkids ready for rebirth of a nation’. One of 3 scientists to be nominated., Sunday Independent Newspaper

2009: Appointed to the RCSI Research Executive as elected head of Infection, Immunity and Regenerative Medicine Research Cluster., RCSI

2009: Appointed as an Editorial Consultant for the Journal of Biomechanics., Journal of Biomechanics

2008: Appointed to Executive (Steering) Committee of the Trinity Centre for Bioengineering, Trinity College Dublin

2007: Guest Editor of a Special Issue of Technology and Healthcare ‘Tissue Engineering for Orthopaedic Applications’., IOS Press

2007: Appointed as a Subject Editor (Tissue Engineering) for the Journal of the Mechanical Behavior of Biomedical Materials., Journal of the Mechanical Behavior of Biomedical Materials (Elsevier)

2007: Co-author on paper which won Genzyme Award for Excellence in Cartilage Research 2007, ‘Tracking bone marrow stromal cells with iron oxide labelling and its effects on multilineage differentiation potential’, International Cartilage Repair Society

2005: Recommended by IEI Board as potential candidate for award of Chartered Engineer of the Year and subsequently nominated as one of 6 finalists. Following interview and presentation of showcase project ‘Bone as a composite material: microcracks and their implications in osteoporosis’ was awarded the prize of Chartered Engineer of the Year at an award ceremony in the Alexander Hotel on November 4th, 2005., Institution of Engineers of Ireland (Engineers Ireland)

2005: Elected for the registered title of Chartered Engineer (CEng), Institution of Engineers of Ireland (Engineers Ireland)

2003: Awarded a Science Foundation Ireland, President of Ireland Young Researcher Award. The award was presented at a ceremony in Aras an Uachtarain by the President of Ireland, Mrs. Mary McAleese on 13th October 2004. The funding (€1.1 million) is being used to set up a laboratory for bone tissue engineering in RCSI., Science Foundation Ireland

2002: Winner, New Investigator Recognition Award for Outstanding Scientific Paper, 48th Annual Meeting of the Orthopaedic Research Society, Dallas, Texas., Orthopaedic Research Society

2001: Awarded Hewlett Packard Fulbright Scholarship to conduct research in the area of bone and tissue engineering at Massachusetts Institute of Technology in collaboration with Cambridge University, UK and Harvard Medical School, Boston, MA., Irish Fulbright Alumni Association

Personal Links

http://pi.rcsi.ie/pi/fjobrien/pi.asp
http://www.rcsi.ie/tissueengineering
http://www.rcsi.ie/anatomyresearchstaff
https://twitter.com/tissueengdublin
https://www.facebook.com/rcsiterg16
https://www.researchgate.net/profile/Fergal_OBrien
http://orcid.org/0000-0003-2030-8005

National Collaborations

Patrick Prendergast, Mechanical Engineering, TCD, Ireland ; Veronica Campbell, Physiology, TCD, Ireland ; Brian O'Connell, School of Dentistry, TCD, Ireland ; Noel Claffey, School of Dentistry, TCD, Ireland ; Danny Kelly, Mechanical Engineering, TCD, Ireland
Trinity Centre for Bioengineering: Tissue Engineering, Theme 2
(May 2003)

Peter McHugh, NUIG, Ireland
Orthopaedic Tissue Engineering
(May 2003)

David Taylor, Mechanical Engineering, TCD, Ireland ; Patrick Prendergast, Mechanical Engineering, TCD, Ireland ; Kevin O'Kelly, Mechanical Engineering, TCD, Ireland ; Susan Rackard, School of Veterinary Medicine, UCD, Ireland
Trinity Centre for Bionegineering, Theme 1: Bone for Life
(May 2003)

International Collaborations

Glenn Dickson, Queen's University Belfast, UK
The Development of a Novel Bone Graft Substitute.
(Oct 2006)

Gerjo van Osch, Erasmas Medical Centre, The Netherlands ; Harrie Weinens, Erasmas Medical Centre, The Netherlands
Tissue engineering for orthopaedic applications: the use of collagen scaffolds for the development of bone graft substitutes
(Oct 2005)

Ioannis Yannas, Mechanical Engineering, MIT, USA ; Lorna Gibson, Materials Science and Engineering, USA ; Myron Spector, Harvard Medical School, USA
Tissue engineering for orthopaedic applications: the use of collagen scaffolds for the development of bone graft substitutes
(Oct 2004)

Industry Collaborations

Christian Jungreuthmayer, Siemens, Austria ; Heinrich Huber, Siemens, Austria
Computational modelling of the pore structure, permeability and mechanical behaviour of collagen-GAG scaffolds for bone tissue engineering
(Jan 2007)

Keynote Lecture

O'Brien FMechanical stimulation of stem cell seeded scaffolds to enhance angiogenesis and identify new therapeutic targets for bone repair
Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Meeting, Uppsala, Sweden (Jun 2016)

O'Brien FNatural polymer-based scaffolds to promote enhanced tissue repair
Applied Biobased-materials Conference 2016, Maastrict, The Netherlands (Apr 2016)

O'Brien FCollagen-based scaffolds for therapeutic delivery to enhance tissue regeneration
2015 Annual Meeting of the Controlled Release Society, Edinburgh, Scotland (Jul 2015)

O'Brien FECM-derived biomaterials as platform systems for the delivery of therapeutics to promote enhanced tissue repair
1st Annual Meeting of Matrix Biology Ireland, Galway, Ireland (Nov 2014)

O'Brien FAdvanced Biomaterials and Stem Cell therapies for Tissue Regeneration
Sheik Mohamed Al Khalifa's Research Committee and Bahrain Medical Bulletin Board, King Hamad University Hospital, Kingdom of Bahrain (Oct 2014)

O'Brien FNatural polymer-based scaffolds for therapeutic delivery to enhanced tissue regeneration
International Society of Biomedical Polymers and Polymeric Biomaterials Annual Conference, Washington D.C. (Jul 2014)

O'Brien FCollagen-based biomaterials as platform systems for controlled delivery of therapeutics to promote enhanced tissue regeneration
World Congress of Biomechanics, Boston, MA (Jul 2014)

O'Brien FCollagen-based scaffolds for controlled delivery of genes and growth factor in tissue engineering
UK Tissue and Cell Engineering Society Annual Meeting, Newcastle, UK (Jul 2014)

O'Brien FCollagen-based scaffolds for orthopaedic regenerative medicine: applied biomaterials and cellular response to biophysical stimuli
World Conference on Regenerative Medicine, Leipzig, Germany (Oct 2009)

Invited Lecture

O'Brien FNatural polymer-based scaffolds as platform systems for the delivery of therapeutics to promote enhanced bone, cartilage and osteochondral tissue repair
2016 Gordon Research Conference on Musculoskeletal Biology and Bioengineering, Proctor Academy, Andover, NH, USA (Aug 2016)

O'Brien FAdvanced biomaterial based strategies for promoting vascularisation in regenerative medicine
Regenerative Medicine for Tissue Healing Symposium, Bahrain (May 2016)

O'Brien FCollagen-based scaffolds as platform systems for the delivery of therapeutics to promote enhanced bone repair
Bone-Tec 2015: International Bone-Tissue Engineering Congress, Stuttgart, Germany (Oct 2015)

O'Brien FNatural polymer-based scaffolds as platform systems for the delivery of therapeutics to promote enhanced tissue repair
Ludwug Boltzmann Institute for Experimental and Clinical Traumatology Seminar Series, Vienna, Austria (Sep 2015)

O'Brien FCollagen-based scaffolds for therapeutic delivery to enhance tissue regeneration
Anatomical Society New Fellow of the Year Prize Lecture, Birmingham, UK (Dec 2014)

O'Brien FOptimisation of collagen scaffold-based systems for cell, drug and gene delivery
2013 Anatomical Society Summer Meeting: Form and Function in Regenerative Medicine, Dublin (Jul 2013)

O'Brien FRequirements for the mechanical and morphological properties of collagen-based scaffolds for tissue engineering applications
5th Freiberg Collagen Symposium, Freiburg, Germany (Sep 2012)

O'Brien FThe effects of oestrogen deficiency and bisphosphonate therapy on BMD and bone quality in an ovine osteoporosis model
Sixth Clare Valley Bone Meeting, Clare, South Australia (Mar 2010)

O'Brien FCollagen-based scaffolds for bone regeneration: applied biomaterials and cellular responses to biophysical stimuli
Sixth Clare Valley Bone Meeting, Clare, South Australia (Mar 2010)

Peer Reviewed Publications

Roche, P.; Alekseeva, T.; Widaa, A.; Ryan, A.; Matsiko, A.; Walsh, M.; Duffy, G.P. and O'Brien, F.J.
Olfactory Derived Stem Cells Delivered in a Biphasic Conduit Promote Peripheral Nerve Repair In Vivo
Stem Cells Transl Med. 2017 Oct;6(10):1894-1904     PMID: 28960910     (Oct 2017)

Ryan, A.J. Lackington, W.A.; Hibbitts, A.J.; Matheson, A.; Alekseeva, T.; Stejskalova, A.; Roche, P. and O'Brien, F.J.
A Physicochemically Optimized and Neuroconductive Biphasic Nerve Guidance Conduit for Peripheral Nerve Repair
Adv Healthc Mater. 2017 Oct 4. doi: 10.1002/adhm.201700954.     PMID: 28975768     (Oct 2017)

Barreto, S.; Gonzalez-Vazquez, A.; Cameron, A.R.; O'Brien, F.J. and Murray, D.J.
Identification of stiffness-induced signalling mechanisms in cells from patent and fused sutures associated with craniosynostosis
Sci Rep. 2017 Sep 13;7(1):11494     PMID: 28904366     (Sep 2017)

Walsh, D.P.; Heise, A.; O'Brien, F.J. and Cryan, S.A.
An efficient, non-viral dendritic vector for gene delivery in tissue engineering
Gene Therapy. 2017. doi: 10.1038/gt.2017.58     PMID: 28905887     (Sep 2017)

do Amaral, R.J.F.C.; Almeida, H.V.; Kelly, D.J.; O'Brien, F.J. and Kearney, C.J.
Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy.
Stem Cells International. 2017 Article 6843727     PMID: 29018484     (Sep 2017)

Ryan, A.J.; O'Neill, H.S.; Duffy, G.P. and O'Brien, F.J.
Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation
Curr Opin Pharmacol. 2017 Aug 30;36:66-71.     PMID: 28865291     (Aug 2017)

Brougham, C.M.; Levingstone, T.J.; Shen, N.; Cooney, G.M.; Jockenhoevel, S.; Flanagan, T.C. and O'Brien, F.J.
Freeze-drying as a Novel Biofabrication Method for Achieving a Controlled Microarchitecture within Large, Complex Natural Biomaterial Scaffolds.
Advanced Healthcare Materials. 2017. 6(21): 1700598     PMID: 28758358     (Jul 2017)

Gilroy, D.A.; Hobbs, C.; Nicolosi, V.; Buckley, C.T.; O'Brien, F.J. and Kearney, C.J.
Development of magnetically active scaffolds as intrinsically-deformable bioreactors
MRS Communications. 2017. 7(3): 367-374     PMID: n/a     (Jun 2017)

Brennan O, Sweeney J, O'Meara B, Widaa A, Bonnier F, Byrne HJ, O'Gorman DM, O'Brien FJ.
A Natural, Calcium-Rich Marine Multi-mineral Complex Preserves Bone Structure, Composition and Strength in an Ovariectomised Rat Model of Osteoporosis.
Calcif Tissue Int. 2017 Jun 24. doi: 10.1007/s00223-017-0299-7. Epub ahead of print     PMID: 28647775     (Jun 2017)

Lebre F, Sridharan R, Sawkins MJ, Kelly DJ, O'Brien FJ, Lavelle EC.
The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation.
Sci Rep. 2017 Jun 7;7(1):2922. doi: 10.1038/s41598-017-03086-0.     PMID: 28592868     (Jun 2017)

Gonzalez-Fernandez T, Sathy BN, Hobbs C, Cunniffe GM, McCarthy HO, Dunne NJ, Nicolosi V, O'Brien FJ, Kelly DJ.
Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector.
Acta Biomater. 2017 Jun;55:226-238.     PMID: 28363788     (May 2017)

Laiva AL, O'Brien FJ, Keogh MB.
Innovations in Gene and Growth Factor delivery systems for Diabetic Wound Healing.
J Tissue Eng Regen Med. 2017 May 8. doi: 10.1002/term.2443. Epub ahead of print Review.     PMID: 28482114     (May 2017)

Davis, N.F.; Cunnane, E.M.; O'Brien, F.J.; Mulvihill, J.J. and Walsh, M.T.
Tissue engineered extracellular matrices (ECMs) in urology: Evolution and future directions
The Surgeon. 2017. pii: S1479-666X(17)30111-7     PMID: 28811169     (Apr 2017)

Barreto, S.; Gonzale-Vazquez, A.; Cameron, A.R.; Cavanagh, B.; Murray, D.J.; O’Brien, F.J.
Identification of the mechanisms by which age alters the mechanosensitivity of mesenchymal stromal cells on substrates of differing stiffness: Implications for osteogenesis and angiogenesis.
Acta Biomaterialia Feb 16. pii: S1742-7061(17)30136-8     PMID: 28216301     (Feb 2017)

Cunniffe, G.M.; Díaz-Payno, P.J.; Ramey, J.S.; Mahon, O.R.; Dunne, A.; Thmpson, E.M.; O’Brien, F.J. and Kelly, D.J.
Growth plate extracellular matrix-derived scaffolds for large bone defect healing.
eCells & Materials 33:130-142. DOI: 10.22203/eCM     PMID: 28197989     (Feb 2017)

O’Leary, C.; O’Brien, F.J. and Cryan, S.A.
Retinoic Acid-Loaded Collagen-Hyaluronate Scaffolds: A Bioactive Material for Respiratory Tissue Regeneration
ACS Biomaterials Science and Engineering. Accepted Manuscript DOI: 10.1021/acsbiomaterials.6b00561     PMID: .     (Feb 2017)

O'Neill HS, Herron CC, Hastings CL, Deckers R, Lopez Noriega A, Kelly HM, Hennink WE, McDonnell CO, O'Brien FJ, Ruiz-Hernández E, Duffy GP.
A stimuli responsive liposome loaded hydrogel provides flexible on-demand release of therapeutic agents.
Acta Biomater. 2017 Jan 15;48:110-119.     PMID: 27773752     (Jan 2017)

Almeida H, Sathy BN, Dudurych I, Buckley CT, O'Brien FJ, Kelly DJ.
Anisotropic Shape-Memory Alginate Scaffolds Functionalized with either Type I or Type II Collagen for Cartilage Tissue Engineering.
Tissue Eng Part A. 2017 Jan;23(1-2):55-68.     PMID: 27712409     (Jan 2017)

Evans, J.C.; Malhotra, M.; Fitzgerald, K.A.; Guo, J.; Cronin, M.F.; Curtin, C. M.; O’Brien, F.J.; Darcy, R. and O’Driscoll, C.M.
Formulation and evaluation of anisamide-targeted amphiphilic cyclodextrin nanoparticles to promote therapeutic gene silencing in a 3D prostate cancer bone metastases model
Molecular Pharmaceutics 3;14(1):42-52     PMID: 28043128     (Jan 2017)

Lackington, W.A.; Ryan, A. and O’Brien, F.J
Advances in nerve guidance conduit-based therapeutics for peripheral nerve repair.
ACS Biomaterials Science & Engineering. Accepted Manuscript DOI: 10.1021/acsbiomaterials.6b00500     PMID: .     (Dec 2016)

O'Neill HS, O'Sullivan J, Porteous N, Ruiz Hernandez E, Kelly HM, O'Brien FJ, Duffy GP
A Collagen Cardiac Patch Incorporating Alginate Microparticles Permits the Controlled Release of HGF and IGF-1 to Enhance Cardiac Stem Cell Migration and Proliferation
Journal of Tissue Engineering and Regenerative Medicine Dec 12. doi: 10.1002/term.2392     PMID: 27943590     (Dec 2016)

Raftery RM, Woods B, Marques AL, Moreira-Silva J, Silva TH, Cryan SA, Reis RL, O'Brien FJ.
Multifunctional biomaterials from the sea: Assessing the effects of chitosan incorporation into collagen scaffolds on mechanical and biological functionality.
Acta Biomater. 2016 Oct 1;43:160-9.     PMID: 27402181     (Oct 2016)

Cunniffe GM, Curtin CM, Thompson EM, Dickson GR, O'Brien FJ.
Content-Dependent Osteogenic Response of Nanohydroxyapatite: An in Vitro and in Vivo Assessment within Collagen-Based Scaffolds.
ACS Appl Mater Interfaces. 2016 Sep 14;8(36):23477-88.     PMID: 27537605     (Sep 2016)

Ryan AJ, Brougham CM, Garciarena CD, Kerrigan SW, O'Brien FJ.
Towards 3D in vitro models for the study of cardiovascular tissues and disease.
Drug Discov Today. 2016 Sep;21(9):1437-45.     PMID: 27117348     (Sep 2016)

Almeida HV, Mulhall KJ, O'Brien FJ, Kelly DJ.
Stem cells display a donor dependent response to escalating levels of growth factor release from extracellular matrix-derived scaffolds.
J Tissue Eng Regen Med. 2016 Jul 12. doi: 10.1002/term.2199. Epub ahead of print     PMID: 27402022     (Jul 2016)

Raftery RM, Walsh DP, Castaño IM, Heise A, Duffy GP, Cryan SA, O'Brien FJ.
Delivering nucleic-acid based nanomedicines on biomaterial scaffolds for orthopaedic tissue repair: challenges, progress and future perspectives
Advanced Materials. Jul;28(27):5447-69.     PMID: 26840618     (Jul 2016)

Kearney, C.J.; O’Brien, F.J. and Castro, C.
DNA Origami: Folded DNA-nanodevices that can direct and interpret cell behavior.
Advanced Materials Jul;28(27):5509-24.     PMID: 26840503     (Jul 2016)

Mencía Castaño I, Curtin CM, Duffy GP, O'Brien FJ.
Next generation bone tissue engineering: non-viral miR-133a inhibition using collagen-nanohydroxyapatite scaffolds rapidly enhances osteogenesis.
Sci Rep. 2016 Jun 14;6:27941.     PMID: 27297802     (Jun 2016)

O'Neill HS, Gallagher LB, O'Sullivan J, Whyte W, Curley C, Dolan E, Hameed A, O'Dwyer J, Payne C, O'Reilly D, Ruiz-Hernandez E, Roche ET, O'Brien FJ, Cryan SA, Kelly H, Murphy B, Duffy GP.
Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives.
Adv Mater. 2016 Jul;28(27):5648-61.     PMID: 26840955     (Jun 2016)

Stack JD, Levingstone TJ, Lalor W, Sanders R, Kearney C, O'Brien FJ, David F.
Repair of large osteochondritis dissecans lesions using a novel multilayered tissue engineered construct in an equine athlete.
J Tissue Eng Regen Med. 2016 May 20. doi: 10.1002/term.2173. Epub ahead of print     PMID: 27198896     (May 2016)

Gonzalez-Fernandez T, Tierney EG, Cunniffe GM, O'Brien FJ, Kelly DJ.
Gene Delivery of TGF-β3 and BMP2 in an MSC-Laden Alginate Hydrogel for Articular Cartilage and Endochondral Bone Tissue Engineering.
Tissue Eng Part A. 2016 May;22(9-10):776-87.     PMID: 27079852     (May 2016)

Almeida HV, Eswaramoorthy R, Cunniffe GM, Buckley CT, O'Brien FJ, Kelly DJ.
Fibrin hydrogels functionalized with cartilage extracellular matrix and incorporating freshly isolated stromal cells as an injectable for cartilage regeneration.
Acta Biomater. 2016 May;36:55-62.     PMID: 26961807     (May 2016)

Leszczynska, A.; O’Doherty, A.; Farrell, E.; Pindjakova, J.; O’Brien, F.J.; O’Brien, T.; Barry, F. and Murphy, M.
Differentiation of vascular stem cells contributes to ectopic calcification of atherosclerotic plaque.
Stem Cells 2016 Apr;34(4):913-23.     PMID: 26840742     (Apr 2016)

Thompson EM, Matsiko A, Kelly DJ, Gleeson J, O'Brien FJ.
An endochondral ossification-based approach to bone repair: Chondrogenically-primed MSC-laden scaffolds support greater repair of critical-sized cranial defects than osteogenically stimulated constructs in vivo.
Tissue Eng Part A. 2016 Mar; 22(5-6):556-67.     PMID: 26896424     (Mar 2016)

Levingstone TJ, Thompson E, Matsiko A, Schepens A, Gleeson JP, O'Brien FJ.
Multi-layered collagen-based scaffolds for osteochondral defect repair in rabbits.
Acta Biomater. 2016 Mar 1;32:149-60.     PMID: 26724503     (Mar 2016)

Levingstone, T.J.; Ramesh, A.C; Brady, R.T.; Brama, P.; Kearney, C.; Gleeson, J.P. and O’Brien F.J
Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints.
Biomaterials 87: 69-81.     PMID: -     (Mar 2016)

O'Leary C, Cavanagh B, Unger RE, Kirkpatrick CJ, O'Dea S, O'Brien FJ, Cryan SA.
The development of a tissue-engineered tracheobronchial epithelial model using a bilayered collagen-hyaluronate scaffold.
Biomaterials. 2016 Feb 1;85:111-127     PMID: 26871888     (Feb 2016)

Moran, C.J.; Ramesh, A.; Brama, P.A.J.; O’Byrne, J.M.; O’Brien, F.J. and Levingstone, T.J.
The benefits and limitations of animal models for translational research in cartilage repair.
Journal of Experimental Orthopaedics, Jan 6 3:1     PMID: -     (Jan 2016)

Murphy CM, Duffy GP, Schindeler A, O'Brien FJ.
Effect of collagen-glycosaminoglycan scaffold pore size on matrix mineralization and cellular behavior in different cell types.
J Biomed Mater Res A. 2016 Jan;104(1):291-304.     PMID: 26386362     (Jan 2016)

Quinlan, E.; Thompson, E.M.; Matsiko, A.; O'Brien, F.J. and López-Noriega, A.
Functionalization of a collagen-hydroxyapatite scaffold with osteostatin to facilitate enhanced bone regeneration
Advanced Healthcare Materials. Dec;4(17):2649-56     PMID: 26414944     (Dec 2015)

Ryan AJ, O'Brien FJ.
Insoluble elastin reduces collagen scaffold stiffness, improves viscoelastic properties, and induces a contractile phenotype in smooth muscle cells.
Biomaterials. 2015 Dec;73:296-307     PMID: 26431909     (Dec 2015)

O'Brien FJ, Duffy GP.
Form and function in regenerative medicine: introduction.
J Anat. 2015 Dec;227(6):705-6. doi: 10.1111/joa.12401     PMID: 26768088     (Dec 2015)

Thompson EM, Matsiko A, Farrell E, Kelly DJ, O'Brien FJ.
Recapitulating endochondral ossification: a promising route to in vivo bone regeneration.
J Tissue Eng Regen Med. 2015 Aug;9(8):889-902     PMID: 24916192     (Dec 2015)

Mulcahy LE, Curtin CM, McCoy RJ, O'Brien FJ, Taylor D, Lee TC, Duffy GP.
The effect of bisphosphonate treatment on the biochemical and cellular events during bone remodelling in response to microinjury stimulation.
Eur Cell Mater. 2015 Nov 27;30:271-81.     PMID: 26614482     (Nov 2015)

Cunniffe, G.M.; Vinardell, T.; Thompson, E.; Daly, A.; Matsiko, A.; O’Brien, F.J. and Kelly, D.J.
Chondrogenically primed mesenchymal stem cell-seeded alginate hydrogels promote early bone formation in critically-sized defects
European Polymer Journal 72: 464-472.     PMID: -     (Nov 2015)

Fitzgerald KA, Guo J, Tierney EG, Curtin CM, Malhotra M, Darcy R, O'Brien FJ, O'Driscoll CM.
The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics.
Biomaterials. 2015 Oct;66:53-66. doi: 10.1016/j.biomaterials.2015.07.019     PMID: 26196533     (Oct 2015)

Cunniffe GM, Vinardell T, Murphy JM, Thompson EM, Matsiko A, O'Brien FJ, Kelly DJ.
Porous decellularized tissue engineered hypertrophic cartilage as a scaffold for large bone defect healing.
Acta Biomater. 2015 Sep 1;23:82-90. doi: 10.1016/j.actbio.2015.05.031.     PMID: 26038199     (Sep 2015)

Lloyd-Griffith C, McFadden TM, Duffy GP, Unger RE, James Kirkpatrick C, O'Brien FJ.
The pre-vascularisation of a collagen-chondroitin sulphate scaffold using human amniotic fluid-derived stem cells to enhance and stabilise endothelial cell-mediated vessel formation.
Acta Biomater. 2015 Aug 20. pii: S1742-7061(15)30074-X.     PMID: 26300337     (Aug 2015)

Brougham CM, Levingstone TJ, Jockenhoevel S, Flanagan TC, O'Brien FJ.
Incorporation of fibrin into a collagen-glycosaminoglycan matrix results in a scaffold with improved mechanical properties and enhanced capacity to resist cell-mediated contraction.
Acta Biomater. 2015 Aug 19. pii: S1742-7061(15)30066-0.     PMID: 26297884     (Aug 2015)

O’Leary, C.; O’Dea, S.; O’Brien, F.J. and Cryan, S.A.
Respiratory Tissue Engineering: Current Status and Opportunities for the Future.
Tissue Engineering: Part B 2015 Aug;21(4):323-44.     PMID: 25587703     (Aug 2015)

Fitzgerald KA, Malhotra M, Curtin CM, O' Brien FJ, O' Driscoll CM.
Life in 3D is never flat: 3D models to optimise drug delivery.
J Control Release. 2015 Jul 26;215:39-54. Review     PMID: 26220617     (Jul 2015)

Raftery RM, Tierney EG, Curtin CM, Cryan SA, O'Brien FJ.
Development of a gene-activated scaffold platform for tissue engineering applications using chitosan-pDNA nanoparticles on collagen-based scaffolds.
J Control Release. 2015 Jul 28;210:84-94.     PMID: 25982680     (Jul 2015)

Brennan, O.; Stenson, B.J.; O’Gorman, D.M. and O'Brien, F.J.
Incorporation of the natural marine multi-mineral dietary supplement Aquamin enhances osteogenesis and improves the mechanical properties of a collagen-based bone graft substitute.
Journal of the Mechanical Behavior of Biomedical Materials Jul;47:114-23     PMID: 25884141     (Jul 2015)

do Amaral RJ, Matsiko A, Tomazette MR, Rocha WK, Cordeiro-Spinetti E, Levingstone TJ, Farina M, O'Brien FJ, El-Cheikh MC, Balduino A.
Platelet-rich plasma releasate differently stimulates cellular commitment toward the chondrogenic lineage according to concentration.
J Tissue Eng. 2015 Jul 7;6:2041731415594127.     PMID: 26380066     (Jul 2015)

Quinlan, E.; Thompson, E.M.; Matsiko, A.; O'Brien, F.J. and López-Noriega, A.
Long-term controlled delivery of rhBMP-2 from collagen-hydroxyapatite scaffolds for superior bone tissue regeneration
Journal of Controlled Release 2015 Jun;4(8):1175-9     PMID: 25817394     (Jun 2015)

Matsiko, A.; Levingstone, T.J.; Gleeson, J.P. and O'Brien, F.J.
Incorporation of TGF-Beta 3 within Collagen-Hyaluronic Acid Scaffolds Improves their Chondrogenic Potential.
Adv Healthc Mater. 2015 Jun;4(8):1175-9.     PMID: 25800862     (Jun 2015)

Quinlan, E.; Partap, S.; Azevedo, M.M.; Jell, G.; Stevens, M.M. and O’Brien, F.J.
Hypoxia-mimicking bioactive glass/collagen glycosaminoglycan composite scaffolds to enhance angiogenesis and bone repair.
Biomaterials Jun;52:358-66     PMID: 25818442     (Jun 2015)

Cunniffe GM, Vinardell T, Mary Murphy J, Thompson EM, Matsiko A, O'Brien FJ, Kelly DJ.
Porous decellularized tissue engineered hypertrophic cartilage as a scaffold for large bone defect healing.
Acta Biomater. 2015 May 30. pii: S1742-7061(15)00255-X. doi: 10.1016/j.actbio.2015.05.031.     PMID: 26038199     (May 2015)

Sridharan, R.; Cameron, A.R; Kelly, D.J.; Kearney, C. and O'Brien, F.J.
Biomaterial based modulation of macrophage polarization: A review and suggested design principles.
Materials Today 18(6): 313-325.     PMID: -     (May 2015)

Lloyd-Griffith, C.; Duffy, G.P. and O’Brien, F.J.
Investigating the effect of hypoxic culture on the endothelial differentiation of human amniotic fluid-derived stem cells.
Journal of Anatomy Dec; 227(6): 767-780.     PMID: 25833670     (Apr 2015)

Lloyd-Griffith C, Duffy GP, O'Brien FJ.
Investigating the effect of hypoxic culture on the endothelial differentiation of human amniotic fluid-derived stem cells.
J Anat. 2015 Mar 31. doi: 10.1111/joa.12283. Epub ahead of print     PMID: 25833670     (Mar 2015)

Brady RT, O'Brien FJ, Hoey DA.
Mechanically stimulated bone cells secrete paracrine factors that regulate osteoprogenitor recruitment, proliferation, and differentiation.
Biochem Biophys Res Commun. 2015 Mar 27;459(1):118-23     PMID: http://www.ncbi.nlm.nih.gov/pubmed/25721667     (Mar 2015)

Quinlan E, López-Noriega A, Thompson EM, Hibbitts A, Cryan SA, O'Brien FJ.
Controlled release of vascular endothelial growth factor from spray-dried alginate microparticles in collagen-hydroxyapatite scaffolds for promoting vascularization and bone repair.
J Tissue Eng Regen Med. 2015 Mar 18. doi: 10.1002/term.2013. Epub ahead of print     PMID: 25783558     (Mar 2015)

Claro T, Kavanagh N, Foster TJ, O'Brien FJ, Kerrigan SW.
Staphylococcus epidermidis serine-aspartate repeat protein G (SdrG) binds to osteoblast integrin alpha V beta 3.
Microbes Infect. 2015 Mar 5. pii: S1286-4579(15)00037-4.     PMID: 25749709     (Mar 2015)

López-Noriega, A.; Quinlan, E.; Celikkin, N. and O'Brien, F.J.
Incorporation of polymeric microparticles into collagen-hydroxyapatite scaffolds for the delivery of a pro-osteogenic peptide for bone tissue engineering.
APL Materials: Special Issue on Biomaterials & Bioelectronics     PMID: -     (Mar 2015)

Castaño IM, Curtin CM, Shaw G, Mary Murphy J, Duffy GP, O'Brien FJ.
A novel collagen-nanohydroxyapatite microRNA-activated scaffold for tissue engineering applications capable of efficient delivery of both miR-mimics and antagomiRs to human mesenchymal stem cells.
J Control Release. 2015 Feb 28;200C:42-51     PMID: 25550154     (Feb 2015)

David, F.; Levingstone, T.J.; de Swarte, M.; Jahns, H.; Gleeson, J.P. and O'Brien, F.J.
Enhanced bone healing using collagen-hydroxyapatite scaffold implantation in the treatment of a large multiloculated mandibular aneurysmal bone cyst in a Thoroughbred filly
Journal of Tissue Engineering & Regenerative Medicine Oct;9(10):1193-9.     PMID: 25712436     (Feb 2015)

Brady RT, O'Brien FJ, Hoey DA.
Mechanically stimulated bone cells secrete paracrine factors that regulate Osteoprogenitor recruitment, Proliferation, and differentiation.
Biochem Biophys Res Commun. 2015 Epub ahead of print     PMID: 25721667     (Feb 2015)

Almeida, H.V.; Cunniffe, G.M.; Vinardell, T.; Buckley, C.T.; O’Brien, F.J.; Kelly, D.J. (
Coupling freshly isolated CD44+ infrapatellar fat pad derived stromal cells with a TGF-β3 eluting cartilage ECM-derived scaffold as a single stage strategy for promoting chondrogenesis.
Advanced Healthcare Materials 2015 Feb 6. doi: 10.1002/adhm.201400687. Epub ahead of print     PMID: 25656563     (Feb 2015)

Matsiko A, Gleeson J, O'Brien FJ.
Scaffold mean pore size influences mesenchymal stem cell chondrogenic differentiation and matrix deposition.
Tissue Eng Part A. 2015 Feb;21(3-4):486-97     PMID: 25203687     (Feb 2015)

Quinlan E, López-Noriega A, Thompson E, Kelly HM, Cryan SA, O'Brien FJ
Development of collagen-hydroxyapatite scaffolds incorporating PLGA and alginate microparticles for the controlled delivery of rhBMP-2 for bone tissue engineering.
J Control Release. 2015 Jan 28;198:71-9.     PMID: 25481441     (Jan 2015)

Curtin CM, Tierney EG, McSorley K, Cryan SA, Duffy GP, O'Brien FJ.
Combinatorial Gene Therapy Accelerates Bone Regeneration: Non-Viral Dual Delivery of VEGF and BMP2 in a Collagen-Nanohydroxyapatite Scaffold.
Adv Healthc Mater. Jan;4(2):223-7.     PMID: 25125073     (Jan 2015)

Ryan AJ, Gleeson JP, Matsiko A, Thompson EM, O'Brien FJ.
Effect of different hydroxyapatite incorporation methods on the structural and biological properties of porous collagen scaffolds for bone repair.
J Anat. 2015 Dec; 227(6): 732-745.     PMID: 25409684     (Nov 2014)

Sheridan WS, Ryan AJ, Duffy GP, O'Brien FJ, Murphy BP.
An Experimental Investigation of the Effect of Mechanical and Biochemical Stimuli on Cell Migration Within a Decellularized Vascular Construct.
Ann Biomed Eng. 2014 Oct;42(10):2029-38.     PMID: 24986334     (Oct 2014)

Groeneveldt LC, Knuth C, Witte-Bouma J, O'Brien FJ, Wolvius EB, Farrell E.
Enamel Matrix Derivative has No Effect on the Chondrogenic Differentiation of Mesenchymal Stem Cells.
Front Bioeng Biotechnol. 2014 Sep 2;2:29.     PMID: 25229057     (Sep 2014)

Roche ET, Hastings CL, Lewin SA, Shvartsman DE, Brudno Y, Vasilyev NV, O'Brien FJ, Walsh CJ, Duffy GP, Mooney DJ.
Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart.
Biomaterials. 2014 Aug;35(25):6850-8.     PMID: 24862441     (Aug 2014)

López-Noriega A, Ruiz-Hernández E, Quinlan E, Storm G, Hennink WE, O'Brien FJ.
Thermally triggered release of a pro-osteogenic peptide from a functionalized collagen-based scaffold using thermosensitive liposomes.
J Control Release 2014 Aug 10;187:158-66     PMID: 24878185     (Aug 2014)

Brennan MA, Haugh MG, O'Brien FJ, McNamara LM
Estrogen Withdrawal from Osteoblasts and Osteocytes Causes Increased Mineralization and Apoptosis.
Horm Metab Res. 2014 46(08): 537-545     PMID: 24446157     (Jun 2014)

Almeida HV, Liu Y, Cunniffe GM, Mulhall KJ, Matsiko A, Buckley CT, O'Brien FJ, Kelly DJ.
Controlled release of transforming growth factor-β3 from cartilage-extra-cellular-matrix-derived scaffolds to promote chondrogenesis of human-joint-tissue-derived stem cells.
Acta Biomater. 2014 Jun 4. pii: S1742-7061(14)00242-6     PMID: 24907658     (Jun 2014)

López-Noriega A, Hastings CL, Ozbakir B, O'Donnell KE, O'Brien FJ, Storm G, Hennink WE, Duffy GP, Ruiz-Hernández E.
Hyperthermia-Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy.
Adv Healthc Mater. 2014 Jun;3(6):854-9.     PMID: 24436226     (Jun 2014)

Murphy CM, Schindeler A, Gleeson JP, Yu NY, Cantrill LC, Mikulec K, Peacock L, O'Brien FJ, Little DG.
A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates.
Acta Biomater. 2014 May;10(5):2250-8.     PMID: 24456759     (May 2014)

Levingstone TJ, Matsiko A, Dickson G, O'Brien FJ, Gleeson JP.
A biomimetic multi-layered collagen-based scaffold for osteochondral repair.
Acta Biomater. 2014 May;10(5):1996-2004.     PMID: 24418437     (May 2014)

Widaa A, Brennan O, O'Gorman DM, O'Brien FJ
The osteogenic potential of the marine-derived multi-mineral formula aquamin is enhanced by the presence of vitamin D.
Phytother Res. 2014 May;28(5):678-84     PMID: 23873476     (May 2014)

Lyons, F.; Gleeson, J.P.; Partap, S. and O'Brien, F.J.
Novel micro-hydroxyapatite particles in a collagen scaffold: a bioactive bone void filler?
Clin Orthop Relat Res. 2014 Apr;472(4):1318-28.     PMID: 24385037     (Apr 2014)

Brennan MA, Gleeson JP, O'Brien FJ, McNamara LM.
Effects of ageing, prolonged estrogen deficiency and zoledronate on bone tissue mineral distribution.
J Mech Behav Biomed Mater. 2014 Jan;29:161-70.     PMID: 24090875     (Jan 2014)

McFadden TM, Duffy GP, Allen AB, Stevens HY, Schwarzmaier SM, Plesnila N, Murphy MJ, Barry FP, Guldberg RE, O'Brien FJ
The delayed addition of human mesenchymal stem cells to pre-formed endothelial cell networks results in functional vascularization of a collagen-glycosaminoglycan scaffold in vivo.
Acta Biomater. 2013 Dec; 9(12):9303-16.     PMID: 23958783     (Dec 2013)

McCoy RJ, Widaa A, Watters KM, Wuerstle M, Stallings RL, Duffy GP, O'Brien FJ.
Orchestrating osteogenic differentiation of mesenchymal stem cells - identification of placental growth factor as a mechanosensitive gene with a pro-osteogenic role.
Stem Cells. 2013 Nov;31(11):2420-31.     PMID: 23897668     (Nov 2013)

Murphy CM, O'Brien FJ, Little DG, Schindeler A.
Cell-scaffold interactions in the bone tissue engineering triad.
Eur Cell Mater. 2013 Sep 20;26:120-32     PMID: 24052425     (Sep 2013)

Holland JC, Brennan O, Kennedy OD, Mahony NJ, Rackard S, O'Brien FJ, Lee TC.
Examination of osteoarthritis and subchondral bone alterations within the stifle joint of an ovariectomised ovine model.
J Anat. 2013 Jun222(6):588-97     PMID: 23634692     (Jun 2013)

Raftery R, O'Brien FJ, Cryan SA.
Chitosan for gene delivery and orthopedic tissue engineering applications.
Molecules. 2013 May 1518(5):5611-47.     PMID: 23676471     (May 2013)

Tierney EG, Duffy GP, Cryan SA, Curtin CM, O'Brien FJ.
Non-viral gene-activated matrices- next generation constructs for bone repair.
Organogenesis. 2013 Jan 19(1)     PMID: 23538777     (Apr 2013)

Matsiko A, Levingstone TJ, O'Brien FJ.
Advanced strategies for articular cartilage defect repair
Materials 6: 637-668. Review.     PMID: -     (Mar 2013)

Tierney, E.G. McSorley, K. Hastings, C.L. Cryan, S.A. Murphy, M.J. Barry, F.P. O’Brien, T. O’Brien, F.J. and Duffy, G.P.
High levels of ephrinB2 over-expression increases the osteogenic differentiation of human mesenchymal stem cells & promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinB2 gene-activated matrix
Journal of Controlled Release Feb 10165(3):173-82.     PMID: 23201622     (Feb 2013)

Holland JC, Brennan O, Kennedy OD, Rackard SM, O'Brien FJ, Lee TC.
Subchondral osteopenia and accelerated bone remodelling post-ovariectomy - a possible mechanism for subchondral microfractures in the aetiology of spontaneous osteonecrosis of the knee?
Journal of Anatomy Feb 222(2):231-8.     PMID: 23171138     (Feb 2013)

Claro T, Widaa A, McDonnell C, Foster TJ, O'Brien FJ, Kerrigan SW.
Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and release of interleukin-6 in bone infection.
Microbiology. 2013 Jan;159(Pt 1):147-54     PMID: 23154968     (Jan 2013)

McCoy RJ, O'Brien FJ.
Visualizing feasible operating ranges within tissue engineering systems using a "windows of operation" approach: A perfusion-scaffold bioreactor case study.
Biotechnol Bioeng. 2012 Dec 109(12):3161-71.     PMID: 22627891     (Dec 2012)

Brennan, O Kuliwaba, J.S. Lee, T.C. Parkinson, I.H. Fazzalari, N.L. McNamara, L.M. and O’Brien, F.J
Temporal changes in bone composition, architecture and strength following estrogen deficiency in osteoporosis.
Calcified Tissue International 2012 Dec 91(6):440-9     PMID: 23076448     (Dec 2012)

Hoey DA, Tormey S, Ramcharan S, O'Brien FJ, Jacobs CR.
Primary Cilia Mediated Mechanotransduction in Human Mesenchymal Stem Cells.
Stem Cells. Nov; 30(11):2561-70.     PMID: 22969057     (Nov 2012)

Widaa A, Claro T, Foster TJ, O'Brien FJ, Kerrigan SW.
Staphylococcus aureus Protein A Plays a Critical Role in Mediating Bone Destruction and Bone Loss in Osteomyelitis.
PLoS One. 2012;7(7):e40586     PMID: 22792377     (Jul 2012)

Hastings CL, Kelly HM, Murphy MJ, Barry FP, O'Brien FJ, Duffy GP.
Development of a thermoresponsive chitosan gel combined with human mesenchymal stem cells and desferrioxamine as a multimodal pro-angiogenic therapeutic for the treatment of critical limb ischaemia.
J Control Release. 2012 Jul 10;161(1):73-80. Epub 2012 Apr 27.     PMID: 22562065     (Jul 2012)

Murphy, C.M.; Matsiko, A.; Haugh, M.G.; Gleeson J.P. and O'Brien, F.J.
Mesenchymal stem cell fate is regulated by the composition and mechanical properties of collagen-glycosaminoglycan scaffolds.
J Mech Behav Biomed Mater. 2012 Jul;11:53-62.     PMID: 22658154     (Jul 2012)

Matsiko, A. Levingstone, T.J. O'Brien, F.J. and Gleeson J.P.
Addition of hyaluronic acid improves cellular infiltration and promotes early-stage chondrogenesis in a collagen-based scaffold for cartilage tissue engineering.
J Mech Behav Biomed Mater. 2012 Jul11:41-52.     PMID: 22658153     (Jul 2012)

O'Brien FJ, Harley BA.
Editorial: Special Issue on Tissue Engineering
J Mech Behav Biomed Mater. 2012 Jul;11:1-2     PMID: 22658149     (Jun 2012)

McCoy RJ, Jungreuthmayer C, O'Brien FJ.
Influence of flow rate and scaffold pore size on cell behavior during mechanical stimulation in a flow perfusion bioreactor.
Biotechnol Bioeng. 2012 Jun109(6):1583-94     PMID: 22249971     (Jun 2012)

Lim Fat D, Kennedy J, Galvin R, O'Brien F, Mc Grath F, Mullett H.
The Hounsfield value for cortical bone geometry in the proximal humerus-an in vitro study.
Skeletal Radiol. May;41(5):557-68.     PMID: 21932054     (May 2012)

Presbitero G, O'Brien FJ, Lee TC, Taylor D.
Distribution of microcrack lengths in bone in vivo and in vitro.
J Theor Biol. 2012 304C:164-171.     PMID: 22498804     (Apr 2012)

Tierney EG, Duffy GP, Hibbitts AJ, Cryan SA, O'Brien FJ.
The development of non-viral gene-activated matrices for bone regeneration using polyethyleneimine (PEI) and collagen-based scaffolds.
J Control Release. 2012 Mar 10;158(2):304-11.     PMID: 22138069     (Apr 2012)

Alhag M, Farrell E, Toner M, Lee TC, O'Brien FJ, Claffey N.
Evaluation of the ability of collagen-glycosaminoglycan scaffolds with or without mesenchymal stem cells to heal bone defects in Wistar rats.
Oral Maxillofac Surg. 2012 Mar;16(1):47-55     PMID: 21968608     (Mar 2012)

Curtin, C.; Lyons, F.; Cunniffe, G.M.; Duffy, G.P. and O’Brien, F.J.
Innovative collagen nano-hydroxyapatite based scaffolds offer a highly efficient non-viral gene delivery platform for stem cell-mediated bone repair.
Advanced Materials 2012; 24(6):749-54.     PMID: 22213347     (Feb 2012)

Brennan O, O'Brien FJ, McNamara LM.
Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro.
Horm Metab Res. 2012 Feb;44(2):154.     PMID: 22314335     (Feb 2012)

O'Gorman DM, Tierney CM, Brennan O, O'Brien FJ.
The Marine-derived, Multi-mineral formula, Aquamin, Enhances Mineralisation of Osteoblast Cells In Vitro.
Phytother Res. 2011 Jul 12. doi: 10.1002/ptr.3561.     PMID: 21751268     (Jul 2011)

Holland JC, Brennan O, Kennedy OD, Rackard SM, O'Brien FJ, Lee TC.
Subchondral trabecular structural changes in the proximal tibia in an ovine model of increased bone turnover.
J Anat. 2011 Jun;218(6):619-24     PMID: 21477184     (Jun 2011)

Brennan MA, Gleeson JP, Browne M, O'Brien FJ, Thurner PJ, McNamara LM.
Site specific increase in heterogeneity of trabecular bone tissue mineral during oestrogen deficiency.
Eur Cell Mater. 2011 May 15;21:396-406.     PMID: 21574136     (May 2011)

Keogh MB, Partap S, Daly JS, O'Brien FJ.
Three hours of perfusion culture prior to 28 days of static culture, enhances osteogenesis by human cells in a collagen GAG scaffold.
Biotechnol Bioeng. 2011 May;108(5):1203-10.     PMID: 21165906     (May 2011)

Haugh MG, Murphy CM, McKiernan RC, Altenbuchner C, O'Brien FJ.
Crosslinking and mechanical properties significantly influence cell attachment, proliferation and migration within collagen glycosaminoglycan scaffolds.
Tissue Eng Part A. 2011 May;17(9-10):1201-8.     PMID: 21155630     (May 2011)

Claro T, Widaa A, O'Seaghdha M, Miajlovic H, Foster TJ, O'Brien FJ, Kerrigan SW.
Staphylococcus aureus Protein A Binds to Osteoblasts and Triggers Signals That Weaken Bone in Osteomyelitis.
PLoS One. 2011 Apr 15;6(4):e18748.     PMID: 21525984     (Apr 2011)

O'Brien FJ
Biomaterials and scaffolds for tissue engineering.
Materials Today 14: 32-39. Review.     PMID: -     (Apr 2011)

Cunniffe, G.M. and O'Brien, F.J.
Collagen scaffolds for orthopedic regenerative medicine.
JOM: Journal of the Minerals, Metals and Materials Society. 63(4): 66-73. Review.     PMID: -     (Apr 2011)

Alhag M, Farrell E, Toner M, Claffey N, Lee TC, O'Brien F.
Evaluation of early healing events around mesenchymal stem cell-seeded collagen-glycosaminoglycan scaffold. An experimental study in Wistar rats.
Oral Maxillofac Surg. 2011 Mar;15(1):31-9     PMID: 20644972     (Mar 2011)

Duffy GP, McFadden TM, Byrne EM, Gill SL, Farrell E, O'Brien FJ.
Towards in vitro vascularisation of collagen-GAG scaffolds.
Eur Cell Mater. 2011;21:15-30.     PMID: 21225592     (Mar 2011)

Brennan O, O'Brien FJ, McNamara LM.
Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro.
Horm Metab Res. 2012;44(2):154     PMID: 22314335     (Feb 2011)

Brennan O, Kennedy OD, Lee TC, Rackard SM, O'Brien FJ, McNamara LM.
The effects of estrogen deficiency and bisphosphonate treatment on tissue mineralisation and stiffness in an ovine model of osteoporosis.
J Biomech. 2010; 44(3):386-90.     PMID: 21093863     (Feb 2011)

Plunkett N, O'Brien FJ.
Bioreactors in tissue engineering.
Technol Health Care. 2011 19(1):55-69.     PMID: 21248413     (Jan 2011)

Farrell E, Both S, Odorfer KI, Koevoet W, Kops N, O'Brien FJ, Baatenburg de Jong RJ, Verhaar JA, Cuijpers V, Jansen J, Erben RG, van Osch GJ.
In-vivo generation of bone via endochondral ossification by in-vitro chondrogenic priming of adult human and rat mesenchymal stem cells.
BMC Musculoskelet Disord. 2011 Jan 31;12(1):31.     PMID: 21281488     (Jan 2011)

Cunniffe GM, O'Brien FJ, Partap S, Levingstone TJ, Stanton KT, Dickson GR.
The synthesis and characterization of nanophase hydroxyapatite using a novel dispersant-aided precipitation method.
J Biomed Mater Res A. 2010 95A (4):1142-1149.     PMID: 20878985     (Dec 2010)

Gleeson JP, Plunkett NA, O’Brien FJ.
Addition of hydroxyapatite improves stiffness, interconnectivity and osteogenic potential of a highly porous collagen-based scaffold for bone tissue regeneration
eCells and Materials 2010; 20: 218-230.     PMID: 20922667     (Dec 2010)

Lyons FG, Al-Munajjed AA, Kieran SM, Toner ME, Murphy CM, Duffy GP, O'Brien FJ.
The healing of bony defects by cell-free collagen-based scaffolds compared to stem cell-seeded tissue engineered constructs.
Biomaterials. 2010; 31(35):9232-43.     PMID: 20863559     (Dec 2010)

Partap S, Lyons F, O'Brien FJ.
Scaffolds & surfaces
Stud Health Technol Inform. 2010;152:187-201.     PMID: 20407195     (Dec 2010)

McCoy RJ, O'Brien FJ.
Influence of shear stress in perfusion bioreactor cultures for the development of 3d bone tissue constructs: a review.
Tissue Eng Part B Rev. 2010 16(6): 577-585.     PMID: 20799909     (Dec 2010)

Keogh MB, O'Brien FJ, Daly JS.
Substrate stiffness and contractile behaviour modulate the functional maturation of osteoblasts on a collagen-GAG scaffold.
Acta Biomater. 2010 6(11):4305-13.     PMID: 20570642     (Nov 2010)

Haugh MG, Murphy CM, O'Brien FJ.
Novel Freeze-drying Methods to Produce a Range of Collagen-GAG scaffolds with Tailored Mean Pores Sizes.
Tissue Eng Part C Methods. 2010 Oct;16(5):887-94.     PMID: 19903089     (Oct 2010)

Brennan O, Kennedy OD, Lee TC, Rackard SM, O'Brien FJ.
Effects of estrogen deficiency and bisphosphonate therapy on osteocyte viability and microdamage accumulation in an ovine model of osteoporosis.
J Orthop Res. 2011 Mar;29(3):419-24.     PMID: 20886644     (Sep 2010)

Thorpe SD, Buckley CT, Vinardell T, O'Brien FJ, Campbell VA, Kelly DJ.
The response of bone marrow-derived mesenchymal stem cells to dynamic compression following TGF-beta3 induced chondrogenic differentiation.
Ann Biomed Eng. 2010 38(9):2896-909.     PMID: 20458627     (Sep 2010)

Khayyeri H, Checa S, Tägil M, O'Brien FJ, Prendergast PJ.
Tissue differentiation in an in vivo bioreactor: in silico investigations of scaffold stiffness.
J Mater Sci Mater Med. 2010 Aug;21(8):2331-6.     PMID: 20037774     (Aug 2010)

Cunniffe GM, Dickson GR, Partap S, Stanton KT, O'Brien FJ.
Development and characterisation of a collagen nano-hydroxyapatite composite scaffold for bone tissue engineering.
J Mater Sci Mater Med. 2010 ;21(8):2293-8.     PMID: 20091099     (Aug 2010)

Murphy CM, O'Brien FJ.
Understanding the effect of mean pore size on cell activity in collagen-glycosaminoglycan scaffolds
Cell Adh Migr. 2010 Jul 9;4(3). [Epub ahead of print]     PMID: 20421733     (Jul 2010)

Stops, A.J.; Harrison, N.M.; Haugh, M.G.; O'Brien, F.J. and McHugh, P.E.
Local and regional mechanical characterisation of a collagen-glycosaminoglycan scaffold using high-resolution finite element analysis.
Journal of the Mechanical Behavior of Biomedical Materials 2010 May; 3(4):292-302.     PMID: 20346897     (May 2010)

Plunkett N, O'Brien FJ.
Bioreactors in tissue engineering.
Stud Health Technol Inform. 2010;152:214-30.     PMID: 20407197     (May 2010)

Keogh MB, O'Brien FJ, Daly JS
A novel collagen scaffold supports human osteogenesis-applications for bone tissue engineering.
Cell and Tissue Research. 2010 Apr;340(1): 169-177.     PMID: 20198386     (Apr 2010)

Plunkett NA, Partap S, O'Brien FJ.
Osteoblast response to rest periods during bioreactor culture of collagen-glycosaminoglycan scaffolds.
Tissue Eng Part A. 2010 16(3):943-51     PMID: 19827912     (Mar 2010)

Stops AJ, Heraty KB, Browne M, O'Brien FJ, McHugh PE.
A prediction of cell differentiation and proliferation within a collagen-glycosaminoglycan scaffold subjected to mechanical strain and perfusive fluid flow.
J Biomech. 2009 Mar 3; 43(4):618-26.     PMID: 19939388     (Mar 2010)

Healy C, Kennedy OD, Brennan O, Rackard SM, O'Brien FJ, Lee TC.
Structural adaptation and intracortical bone turnover in an ovine model of osteoporosis.
J Orthop Res. 2010 Feb;28(2):248-51.     PMID: 19725098     (Feb 2010)

Murphy CM, Haugh MG, O'Brien FJ
The effect of mean pore size on cell attachment, proliferation and migration in collagen glycosaminoglycan scaffolds for tissue engineering.
Biomaterials. 2010 31: 461–466.     PMID: 19819008     (Jan 2010)

Partap S, Plunkett NA, Kelly DJ, O'Brien FJ.
Stimulation of osteoblasts using rest periods during bioreactor culture on collagen-glycosaminoglycan scaffolds.
J Mater Sci Mater Med. 2010 Aug;21(8):2325-30.     PMID: 20091098     (Jan 2010)

Buckley CT, Thorpe SD, O'Brien FJ, Robinson AJ, Kelly DJ.
The effect of concentration, thermal history and cell seeding density on the initial mechanical properties of agarose hydrogels.
J Mech Behav Biomed Mater. 2009 Oct;2(5):512-21.     PMID: 19627858     (Oct 2009)

Tierney CM, Jaasma MJ, O'Brien FJ.
Osteoblast activity on collagen-GAG scaffolds is affected by collagen and GAG concentrations.
J Biomed Mater Res A. 2009 Sep 2 91A(1):92-101     PMID: 18767061     (Oct 2009)

Al-Munajjed AA, Plunkett NA, Gleeson JP, Weber T, Jungreuthmayer C, Levingstone T, Hammer J, O'Brien FJ.
Development of a biomimetic collagen-hydroxyapatite scaffold for bone tissue engineering using a SBF immersion technique.
J Biomed Mater Res B Appl Biomater. 2009 Aug; 90(2):584-91.     PMID: 19180526     (Aug 2009)

Farrell E, van der Jagt OP, Koevoet W, Kops N, van Manen CJ, Hellingman CA, Jahr H, O'Brien FJ, Verhaar JA, Weinans H, van Osch GJ.
Chondrogenic Priming of Human Bone Marrow Stromal Cells: A Better Route to Bone Repair?
Tissue Eng Part C Methods. 2009 Jun;15(2):285-95.     PMID: 19108678     (Jun 2009)

Jungreuthmayer C, Jaasma MJ, Al-Munajjed AA, Zanghellini J, Kelly DJ, O'Brien FJ.
Deformation simulation of cells seeded on a collagen-GAG scaffold in a flow perfusion bioreactor
Med Eng Phys. 2009 May;31(4):420-427.     PMID: 19109048     (May 2009)

Kennedy OD, Brennan O, Rackard SM, O'Brien FJ, Taylor D, Lee Tc.
Variation of trabecular microarchitectural parameters in cranial, caudal and mid-vertebral regions of the ovine L3 vertebra. Journal of Anatomy 214: 729–735.
J Anat. 2009 214: 729–735.     PMID: 122352275     (May 2009)

Jungreuthmayer C, Donahue SW, Jaasma MJ, Al-Munajjed AA, Zanghellini J, Kelly DJ, O'Brien FJ.
A Comparative Study of Shear Stresses in Collagen-Glycosaminoglycan and Calcium Phosphate Scaffolds in Bone Tissue-Engineering Bioreactors.
Tissue Eng Part A. 2009 15(5):1141-1149.     PMID: 18831686     (May 2009)

Haugh MG, Jaasma MJ, O'Brien FJ.
The effect of dehydrothermal treatment on the mechanical and structural properties of collagen-GAG scaffolds.
J Biomed Mater Res A. 2009 May;89(2):363-9.     PMID: 18431763     (May 2009)

Al-Munajjed, A.A., O'Brien, F.J.
Influence of a novel calcium-phosphate coating on the mechanical properties of highly porous collagen scaffolds for bone repair
J Mech Behav Biomed Mater. 2009 (2) 138-146.     PMID: 12345678     (Apr 2009)

Tierney, C.M., Haugh, M.G., Liedl, J., Mulcahy, F., Hayes, B., O'Brien, F.J.
The effects of collagen concentration and crosslink density on the biological, structural and mechanical properties of collagen-GAG scaffolds for bone tissue engineering
J Mech Behav Biomed Mater. 2009 (2)202-209.     PMID: 12345678     (Mar 2009)

Brennan O, Kennedy OD, Lee TC, Rackard SM, O'Brien FJ.
Biomechanical properties across trabeculae from the proximal femur of normal and ovariectomised sheep.
J Biomech. 2009 Mar 11;42(4):498-503.     PMID: 19171344     (Mar 2009)

Kennedy OD, Brennan O, Rackard SM, Staines A, O'Brien FJ, Taylor D, Lee TC.
Effects of ovariectomy on bone turnover, porosity, and biomechanical properties in ovine compact bone 12 months postsurgery.
J Orthop Res. 2009. 27(3):303-309.     PMID: 18853433     (Mar 2009)

Thorpe SD, Buckley CT, Vinardel T, O'Brien FJ, Campbell VA, Kelly DJ.
Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells.
Biochem Biophys Res Commun. 2008 Dec 12;377(2):458-62.     PMID: 18851955     (Dec 2008)

Kennedy OD, Brennan O, Mauer P, Rackard SM, O'Brien FJ, Taylor D, Lee TC.
The effects of increased intracortical remodeling on microcrack behaviour in compact bone.
Bone. 2008 Oct; (43) 889-893     PMID: 18706535     (Nov 2008)

Byrne EM, Farrell E, McMahon LA, Haugh MG, O'Brien FJ, Campbell VA, Prendergast PJ, O'Connell BC.
Gene expression by marrow stromal cells in a porous collagen-glycosaminoglycan scaffold is affected by pore size and mechanical stimulation.
J Mater Sci Mater Med. 2008 Nov; 19(11):3455-63.     PMID: 18584120     (Nov 2008)

Kennedy OD, Brennan O, Mahony NJ, Rackard SM, O'Brien FJ, Taylor D, Lee CT.
Effects of high bone turnover on the biomechanical properties of the L3 vertebra in an ovine m0del of early stage osteoporosis’
Spine. 2008 Nov 1;33(23):2518-23.     PMID: 18978592     (Nov 2008)

McMahon LA, O'Brien FJ, Prendergast PJ.
Biomechanics and mechanobiology in osteochondral tissues.PMID:
Regen Med. 2008 Sep;3(5):743-59.     PMID: 18729798     (Sep 2008)

Harrison NM, McDonnell PF, O'Mahoney DC, Kennedy OD, O'Brien FJ, McHugh PE.
Heterogeneous linear elastic trabecular bone modelling using micro-CT attenuation data and experimentally measured heterogeneous tissue properties.
J Biomech. 2008 41(11):2589-96.     PMID: 18602110     (Jul 2008)

Farrell E, Wielopolski P, Pavljasevic P, van Tiel S, Jahr H, Verhaar J, Weinans H, Krestin G, O'Brien FJ, van Osch G, Bernsen M.
Effects of iron oxide incorporation for long term cell tracking on MSC differentiation in vitro and in vivo.
Biochem Biophys Res Commun. 2008 May 16;369(4):1076-81.     PMID: 18336785     (May 2008)

Jaasma MJ, O'Brien FJ.
Mechanical Stimulation of Osteoblasts Using Steady and Dynamic Fluid Flow
Tissue Eng Part A. 2008 Apr 23; 14(7): 1213-1223.     PMID: 18433309     (Apr 2008)

Jaasma MJ, Plunkett NA, O'Brien FJ
Design and validation of a dynamic flow perfusion bioreactor for use with compliant tissue engineering scaffolds.
J Biotech. 2008; 133: 490-496.     PMID: 18221813     (Feb 2008)

Kennedy OD, Brennan O, Mauer P, O'Brien FJ, Rackard SM, Taylor D, Lee TC.
The behaviour of fatigue-induced microdamage in compact bone samples from control and ovariectomised sheep.
Stud Health Technol Inform. 2008; 133:148-55.     PMID: 18376023     (Feb 2008)

Al-Munajjed, A.; Gleeson, J.P. and O'Brien, F.J.
Development of a collagen calcium-phosphate scaffold as a novel bone graft substitute
Stud Health Technol Inform. 2008; 133:11-20.     PMID: 18376009     (Jan 2008)

Keeley BJ, Heidari B, Mahony NJ, Rackard SM, O'Brien FJ, Lee TC, Brennan O, Kennedy OD, Fitzpatrick D.
Biomechanical comparison of the pullout properties of external skeletal fixation pins in the tibiae of intact and ovariectomised ewes.
Vet Comp Orthop Traumatol. 2008;21(5):418-26.     PMID: 19011705     (Jan 2008)

O'Brien, F.J.; Taylor, D. and Lee, T.C.
Bone as a composite material: the role of osteons as barriers to crack growth in compact bone.
International Journal of Fatigue (Invited Article) 2007 (29): 1051–1056.     PMID: JIJF1695     (Jun 2007)

Taylor D, Hazenberg J, O'Brien FJ, Lee TC.
How does bone detect cracks? Jaasma MJ, Plunkett NA, O'Brien FJ
Key Engineering Materials 2007; 348-349: 57-60     PMID: N/A     (Jun 2007)

Farrell E, Byrne EM, Fischer J, O'Brien FJ, O'Connell BC, Prendergast PJ, Campbell VA.
A comparison of the osteogenic potential of adult rat mesenchymal stem cells cultured in 2-D and on 3-D collagen glycosaminoglycan scaffolds.
Technol Health Care. 2007;15(1):19-31.     PMID: 17264410     (Jan 2007)

O'Brien FJ, Harley BA, Waller MA, Yannas IV, Gibson LJ, Prendergast PJ.
The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering.
Technol Health Care. 2007;15(1):3-17.     PMID: 17264409     (Jan 2007)

Lee TC, O'Brien FJ, Gunnlaugsson T, Parkesh R, Taylor D.
Microdamage and bone mechanobiology.
Technol Health Care. 2006;14(4-5):359-65.     PMID: 17065757     (Jul 2006)

Mohsin S, O'Brien FJ, Lee TC.
Microcracks in compact bone: a three-dimensional view.
J Anat. 2006 Jul;209(1):119-24.     PMID: 16822275     (Jul 2006)

Farrell E, O'Brien FJ, Doyle P, Fischer J, Yannas I, Harley BA, O'Connell B, Prendergast PJ, Campbell VA.
A collagen-glycosaminoglycan scaffold supports adult rat mesenchymal stem cell differentiation along osteogenic and chondrogenic routes.
Tissue Eng. 2006 Mar;12(3):459-68     PMID: 16579679     (Mar 2006)

Mohsin S, O'Brien FJ, Lee TC
Osteonal crack barriers in ovine compact bone.
J Anat. 2006; 208(1):81-9     PMID: 16420381     (Jan 2006)

O'Brien FJ, Brennan O, Kennedy OD, Lee TC
Microcracks in cortical bone: how do they affect bone biology?
Curr Osteoporos Rep. 2005; 3(2):39-45     PMID: 16036100     (Jun 2005)

O'Brien FJ, Taylor D, Clive Lee T
The effect of bone microstructure on the initiation and growth of microcracks.
J Orthop Res. 2005; 23(2):475-80     PMID: 15734265     (Mar 2005)

O'Brien F J, Hardiman DA, Hazenberg JG, Mercy MV, Mohsin S, Taylor D, Lee TC
The behaviour of microcracks in compact bone.
Eur J Morphol. 2005; 42(1-2):71-9     PMID: 16123026     (Feb 2005)

O'Brien FJ, Harley BA, Yannas IV, Gibson LJ
The effect of pore size on cell adhesion in collagen-GAG scaffolds.
Biomaterials. 2005; 26(4):433-41     PMID: 15275817     (Feb 2005)

Moore TL, O'Brien FJ, Gibson LJ
Creep does not contribute to fatigue in bovine trabecular bone.
J Biomech Eng. 2004; 126(3):321-9     PMID: 15341168     (Jun 2004)

O'Brien FJ, Harley BA, Yannas IV, Gibson L
Influence of freezing rate on pore structure in freeze-dried collagen-GAG scaffolds.
Biomaterials. 2004; 25(6):1077-86     PMID: 14615173     (Mar 2004)

Lee TC, Mohsin S, Taylor D, Parkesh R, Gunnlaugsson T, O'Brien FJ, Giehl M, Gowin W
Detecting microdamage in bone.
J Anat. 2003; 203(2):161-72     PMID: 12924817     (Aug 2003)

O'Brien FJ, Taylor D, Lee TC
Microcrack accumulation at different intervals during fatigue testing of compact bone.
J Biomech 2003;36(7):973-80     PMID: 12757806     (Jul 2003)

Taylor D, O'Brien F, Lee TC
A theoretical model for the simulation of microdamage accumulation and repair in compact bone.
Meccanica 2000; 3179: 1-10.     PMID: N/A     (Jul 2002)

O'Brien FJ, Taylor D, Lee TC
An improved labelling technique for monitoring microcrack growth in compact bone.
J Biomech 2002; 35(4):523-6     PMID: 11934422     (Apr 2002)

Taylor D, Falsetti F, O'Brien FJ, O'Reilly P, Banville E, Lee TC
A fatigue based model of disuse osteoporosis.
Computer Methods in Biomechanics and Biomedical Engineering 2001; 4: 413-420     PMID: N/A     (Jan 2001)

Lee TC, O'Brien FJ, Taylor D
The nature of fatigue damage in bone.
International Journal of Fatigue 2000; 22: 847-853.     PMID: N/A     (Nov 2000)

O'Brien FJ, Taylor D, Dickson GR, Lee TC
Visualisation of three-dimensional microcracks in compact bone.
J Anat. 2000; 197(3):413-20     PMID: 11117627     (Oct 2000)

Taylor D, O'Brien F, Prina-Mello A, Ryan C, O'Reilly P, Lee TC
Compression data on bovine bone confirms that a "stressed volume" principle explains the variability of fatigue strength results.
J Biomech 1999;32(11):1199-203     PMID: 10541070     (Nov 1999)

Book Chapters

Gleeson, J.P. and O'Brien, F.J.
Composite Scaffolds for Orthopaedic Regenerative Medicine.
In: Advances in Composite Materials for Medicine and Nanotechnology, B. Attaf (Ed.), InTech, Rijeka, Croatia (ISBN: 978-953-307-235-7).     (Jan 2011)

Plunkett, N.A. and O'Brien, F.J.
Bioreactors in Tissue Engineering.
In: Basic Engineering for Medics and Biologists, An ESEM Primer on Engineering for Medicine, T.C. Lee, P. Niederer (Eds.) IOS Press, Nieuwe Hemweg, (ISBN: 978-1-60750-526-6).     (Jan 2010)

Partap, S.; Lyons, F. and O'Brien, F.J.
Scaffolds & Surfaces.
In: Basic Engineering for Medics and Biologists, An ESEM Primer on Engineering for Medicine, T.C. Lee, P. Niederer (Eds.) IOS Press, Nieuwe Hemweg, (ISBN: 978-1-60750-526-6).     (Jan 2010)

Partap, S.; Plunkett, N.A.; and O'Brien, F.J.
Bioreactors in Tissue Engineering.
In: Tissue Engineering, A. Lazinica (Ed), InTech, Rijeka, Croatia (ISBN 978-953-307-079-): 323-336.     (Mar 2009)

Alhag, M.; Farrell, E.; Lee, T.C.; Claffey, N. and O’Brien, F.J.
Contraction of mesenchymal stem cell–seeded collagen glycosaminoglycan scaffolds during osteogenesis.
In: ICTE International Conference on Tissue Engineering, P.J. Bartolo, P.R. Fernandes, R.B. Ruben, J. Folgado, H. Almeida, N. Alves, A. Mendes (Eds.), IOS Press, Lisbon, Portugal, 203-209.     (Feb 2009)

Farrell, E.; O’Brien, F.J.; and van Osch, G.V.M.
Scaffold considerations for osteochondral tissue engineering
In: The Handbook of Intelligent Scaffolds for Regenerative Medicine, G. Khang (Ed.), Pan Stanford Publishing, Hackensack, USA (ISBN-10: 9814267856).     (Jan 2009)

Kennedy, O.D. and O'Brien, F.J.
Bone Quality: Where Should We Be Looking?
In: Osteoporosis: Etiology, Diagnosis, and Treatment, B.E. Mattingly, A.C. Pillare (Eds.) Nova Science Publishers, NY (ISBN 978-1-60692-397-9): 251-266.     (Jan 2009)

Kennedy, O.D.; Brennan, O.; Mauer, P.; O'Brien, F.J.; Rackard, S.M.; Taylor, D. ; Lee, T.C.
The behaviour of fatigue-induced microdamage in compact bone samples from control and overiectomised sheep.
In: Studies in Health Technology and Informatics, J. Hammer, M. Nerlich, S. Dendorfer (Eds.) IOS Press, Nieuwe Hemweg, Vol 133, pp 148-155.     (Jan 2008)

Al-Munajjed, A.; Gleeson, J.P. and O'Brien, F.J.
Development of a collagen CP scaffold as a bone graft substitute.
In: Studies in Health Technology and Informatics, J. Hammer, M. Nerlich, S. Dendorfer (Eds.) IOS Press, Nieuwe Hemweg, Vol 133, pp 11-20.     (Jan 2008)

Lee, T.C.; O'Brien, F.J.; Mohsin, S.; Hazenberg, J.G. and Taylor, D
Microstructure and microdamage in bone.
In: Micro- and Nanostructures of Biological Systems G. Bischoff (Ed). Shaker Verlag, Aachen (ISBN: 3 8322 3868 9) pp: 13-27.     (Feb 2005)

Lee, T.C.; O'Brien, F.J.; Taylor, D.; Parkesh, R. and Gunnlaugsson, T.
Visualisation and quantification of fatigue induced microdamage in bone: histology and radiology.
In: Proceedings of the 11th International Conference on Fracture. Dept. of Structural Engineering and Geotechnics, Politecnico di Torino: 3740-3745.     (Jan 2005)

O'Brien, F.J.; Taylor, D and Lee, T.C.
Breaking bones: the effect of microdamage on the fatigue behaviour of compact bone
In: Proceedings of the 11th International Conference on Fracture. Dept. of Structural Engineering and Geotechnics, Politecnico di Torino: 3740-3745.     (Jan 2005)

O'Brien, F.J.; Farrell, E; Waller, M.A.; Connell, I.; O’Mahony, D.; McGarry, J.P.; Murphy, B.P.; McHugh, P.E.; Campbell, V.A. and Prendergast, P.J.
Scaffolds and cells: preliminary biomechanical analysis and results for the use of a collagen-GAG scaffold for bone tissue engineering.
In: Topics in Bio-Mechanical Engineering, P.J. Prendergast and P.E. McHugh (Eds). (ISBN: 0 9548583 0 1): pp 167-183.     (Jan 2004)

Lee, T.C.; McHugh, P.E.; O'Brien, F.J.; O’Mahony, D.; Taylor, D.; Bruzzi, M. ; Rackard, S.M. ; Kennedy, O.D.; Mahony N.J.; Harrison N.; Lohfield S., Brennan, O.; Gleeson J.; Hazenberg, J.G.; Mullins L.; Tyndyk, M.; McNamara, L.M. and Prendergast, P.J. (
“Bone for life”: osteoporosis, bone remodelling and computer simulation.
In: Topics in Bio-Mechanical Engineering, P.J. Prendergast and P.E. McHugh (Eds). (ISBN: 0 9548583 0 1) pp:58-93.     (Jan 2004)

Taylor, D.; O'Brien, F.J. and Lee, T.C.
Damage accumulation in bone: theory and practice.
In: Computer Methods in Biomechanics and Biomedical Engineering - 4 J. Middleton, N.G., Shrive and M.L. Jones (Eds.) Gordon & Breach: Amsterdam (ISBN: 1 903847 09 5) pp:386-391.     (Feb 2002)

Hazenberg, J.G.; O'Brien, F.J.; Lee, T.C. and Taylor, D
Microcrack growth and shape development in compact bone.
In: Computer Methods in Biomechanics and Biomedical Engineering - 4 J. Middleton, N.G., Shrive and M.L. Jones (Eds.) Gordon & Breach: Amsterdam (ISBN: 1 903847 09 5) pp:410-415.     (Feb 2002)

Mohsin, S.; Mercy, M.V.; O'Brien, F.J.; Taylor, D and Lee, T.C.
Computerised three dimensional reconstruction of Haversian systems during bone remodelling.
In: Computer Methods in Biomechanics and Biomedical Engineering - 4 J. Middleton, N.G., Shrive and M.L. Jones (Eds.) Gordon & Breach: Amsterdam (ISBN: 1 903847 09 5) pp:944-949.     (Jan 2002)

O'Brien, F.J.; Taylor, D; Dickson, G.R. and Lee, T.C.
Microdamage in bone: a three-dimensional approach
In: Computer Methods in Biomechanics and Biomedical Engineering - 3 J. Middleton, M.L. Jones, N.G. Shrive and G.N. Pande (Eds.) Gordon & Breach: Amsterdam (ISBN: 9056993216) pp: 155-160.     (Jan 2000)

Funding Awards

Funding Agency: SFI
€50000 [RCSI], €0 [Other], ()
World Congress of Biomechanics (WCB) 2018
Lead Applicant : Prof Fergal O'Brien

Funding Agency: HRB
€369917 [RCSI], €0 [Other], (Oct 2017)
Advanced scaffold-based therapeutics for regeneration of large volume, vascularised bone defects
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: Caroline Curtin
Non RCSI Co-applicants: Cathal Moran - TCD, James Dixon - Univ of Nottingham, Kevin Shakesheff - Univ of Nottingham, Heinz Redl - LBI, Valeria Nicolosi - TCD

Funding Agency: EU
€63000 [RCSI], €0 [Other], (Sep 2017)
Development of novel constructs through incorporation of platelet-rich plasma into collagenglycosaminoglycan scaffolds for wound repair
Lead Applicant : Prof Fergal O'Brien

Funding Agency: EU-H2020
€199979 [RCSI], €0 [Other], (May 2017)
Dressing4scars: New 4D printing dressing to treat skin scars
Lead Applicant : Prof Fergal O'Brien
Non RCSI Co-applicants: Alexandra Marques - University of Minho, Rui Reis - University of Minho

Funding Agency: SFI
€1201346 [RCSI], €248793 [Other], (May 2017)
A Bioactive Collagen-Based Conduit For Peripheral Nerve Repair
Lead Applicant : Prof Fergal O'Brien

Funding Agency: SFI
€129357 [RCSI], €0 [Other], (Feb 2017)
Collagen-based, multi-layered scaffold for closure of tympanic membrane perforations (TympanoColl)
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: Andrew Cameron

Funding Agency: EU-H2020
€248063.4 [RCSI], €0 [Other], (Nov 2016)
An investigation into the viability of employing lipoaspirate fluid as a cellular source in the production of small diameter tissue engineered vascular grafts
Lead Applicant : Prof Fergal O'Brien

Funding Agency: EU-H2020
€202179 [RCSI], €790840 [Other], (Jan 2016)
Gene2Skin - Roadmap for advanced genetic engineering-based skin therapies
Lead Applicant : Prof Fergal O'Brien
Non RCSI Co-applicants: Rui Reis - Minho, Fiona Watt - King

Funding Agency: Industry
€72691 [RCSI], €0 [Other], (Nov 2015)
A Bioactive Collagen-Based Conduit For Peripheral Nerve Repair
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: Ozlem Aslan

Funding Agency: Irish Research Council
€96000 [RCSI], €0 [Other], (Aug 2015)
Novel antibiotic-free scaffold for the treatment of infection and regeneration of bone
Lead Applicant : Prof Fergal O'Brien

Funding Agency: Temple Street Children
€154340 [RCSI], €0 [Other], (Jul 2015)
Understanding the mechanisms underpinning the influence of age and craniosynostosis on the regenerative capacity of cells & tissues
Lead Applicant : Prof Fergal O'Brien

Funding Agency: SFI
€15028.04 [RCSI], €0 [Other], (Jul 2015)
Development of gene-activated smart scaffold for gene repair
Lead Applicant : Prof Fergal O'Brien

Funding Agency: Irish Research Council
€91790 [RCSI], €0 [Other], (Jun 2015)
The Development of a Novel Construct for Peripheral Nerve Repair
Lead Applicant : Prof Fergal O'Brien

Funding Agency: EU-H2020
€187866 [RCSI], €0 [Other], (May 2015)
Temporally controlled delivery of vascular therapeutics from a regenerative template for diabetic wound healing
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: Cathal Kearney

Funding Agency: European Research Council
€149450 [RCSI], €0 [Other], (Apr 2015)
miRaColl: microRNA-activated Scaffold Technologies for Cartilage Regeneration
Lead Applicant : Prof Fergal O'Brien

Funding Agency: SFI
€593138 [RCSI], €0 [Other], (Feb 2015)
Endothelial dysfunction in severe blood stream infection
Lead Applicant : Dr Steve Kerrigan
RCSI Co-applicants: Hilary Humphreys, Fergal O'Brien - RCSI, Raymond Stallings - RCSI
Non RCSI Co-applicants: Timothy Foster - TCD, Philip Cummins - DCU

Funding Agency: HRB
€285163 [RCSI], €0 [Other], (Nov 2014)
Development of Bioactive Therapeutics Harnessing Stem Cell Mechanobiology
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: Andrew Cameron, Raymond Stallings - RCSI
Non RCSI Co-applicants: Dylan Murray - Temple St Hospital

Funding Agency: Irish Research Council
€91790 [RCSI], €0 [Other], (Sep 2014)
Identification of mechanotransdutive signalling mechanisms associated with age and craniosynostosis with a view to developing advanced bone regeneration strategies
Lead Applicant : Prof Fergal O'Brien

Funding Agency: Irish Research Council
€91790 [RCSI], €0 [Other], (Jul 2014)
The Development of Placental Growth Factor-Functionalised, Collagen-Based Scaffolds for Promoting Vascularisation and Bone Repair
Lead Applicant : Prof Fergal O'Brien

Funding Agency: Enterprise Ireland
€554264 [RCSI], €0 [Other], (Jun 2014)
PanaColl: Collagen-Scaffold Based Systems for the Delivery of Antibiotics for the Treatment of Microbial Infections & Enhancement of Tissue Regeneration
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: Andrew Cameron

Funding Agency: EMBO
€8087 [RCSI], €0 [Other], (May 2014)
In vitro vascularisation of scaffolds for bone repair using a Human Dermal Microvascular Endothelial cell (HDMEC)/ Human Amniotic Fluid-Derived Stem Cell (AFSC) co-culture system
Lead Applicant : Prof Fergal O'Brien

Funding Agency: SFI
€126852 [RCSI], €0 [Other], (Jan 2014)
The Development of a Novel Construct for Peripheral Nerve Repair
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: Phoebe Roche, Michael Walsh - RCSI
Non RCSI Co-applicants: Simon Archibald - Integra LifeSciences

Funding Agency: Irish Research Council
€248810.68 [RCSI], €0 [Other], (Nov 2013)
A recombinant approach to cell-matrix interactions and vascular tissue engineering
Lead Applicant : Prof Fergal O'Brien
Non RCSI Co-applicants: Sarah Heilshorn - Stanford University, Matthew Haugh - NUIG

Funding Agency: Irish Research Council
€96000 [RCSI], €0 [Other], (Sep 2013)
Advanced scaffold-based therapeutics to facilitate nerve regeneration
Lead Applicant : Prof Fergal O'Brien
Non RCSI Co-applicants: William Lackington - DCU

Funding Agency: SFI
€1535614 [RCSI], €34002592 [Other], (Aug 2013)
Advanced Materials and Bioengineering Research (AMBER) Centre
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: Garry Duffy, John O'Byrne - RCSI
Non RCSI Co-applicants: John Boland - TCD, Michael Coey - TCD, Jonathan Coleman - TCD, Georg Duesberg - TCD, Michael Morris - UCC, Justin Holmes - UCC, Stefano Sanvito - TCD, Daniel Kelly - TCD

Funding Agency: Enterprise Ireland
€280226 [RCSI], €92405 [Other], (May 2013)
CardioColl Stage II
Lead Applicant : Dr Garry Duffy
RCSI Co-applicants: Fergal O'Brien
Non RCSI Co-applicants: Bruce Murphy - Trinity College Dublin

Funding Agency: Enterprise Ireland
€246717 [RCSI], €0 [Other], (Jan 2013)
Development of Novel Collagen-based Bone and Osteochondral Graft Substitutes for New Surgical Indications of Use
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: John Gleeson
Non RCSI Co-applicants: John Gleeson - SurgaColl Technologies

Funding Agency: SFI
€1281005 [RCSI], €0 [Other], (Jul 2012)
Translation of novel strategies for joint repair from bench to bedside
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: John O'Byrne

Funding Agency: SFI
€128715 [RCSI], €0 [Other], (Jun 2012)
Development of a novel collagen-based film for corneal repair
Lead Applicant : Prof Fergal O'Brien
Non RCSI Co-applicants: Martin Clynes - DCU, Finbarr O - DCU

Funding Agency: Enterprise Ireland
€46179 [RCSI], €59000 [Other], (Dec 2011)
Development of a bi-layered scaffold to enhance the natural cardiac stem cell response in cardiovascular disease and the onset of heart failure.
Lead Applicant : Dr Garry Duffy
RCSI Co-applicants: Fergal O'Brien

Funding Agency: IHF
€3000 [RCSI], €0 [Other], (Nov 2011)
Development of a bioreactor test platform to analyse performance of a novel heart valve scaffold.
Lead Applicant : Prof Fergal O'Brien

Funding Agency: Crescent Diagnostics
€12000 [RCSI], €0 [Other], (Nov 2011)
Collaboration with Crescent Diagnostics
Lead Applicant : Prof Fergal O'Brien

Funding Agency: SFI
€10812 [RCSI], €0 [Other], (Oct 2011)
Investigating the in vivo potential of pre-vascularised collagen based scaffolds for bone tissue regeneration
Lead Applicant : Prof Fergal O'Brien
Non RCSI Co-applicants: Guldberg Robert - Georgia Institute of Technology

Funding Agency: HRB
€298525 [RCSI], €0 [Other], (Jul 2011)
Bone regeneration using stem cell-directed endochondral ossification
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: John Gleeson

Funding Agency: SFI
€0 [RCSI], €198,000 [Other], (Jul 2011)
Development of a cannabinoid-eluting scaffold for orthopaedic tissue engineering strategies
Lead Applicant : Prof Fergal O'Brien
Non RCSI Co-applicants: VA Campbell - TCD

Funding Agency: Enterprise Ireland
€82011 [RCSI], €0 [Other], (May 2011)
Collagen-hydroxyapatite composite scaffolds as bone graft substitutes (HydroxyColl)
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: John Gleeson

Funding Agency: Private Donor
€30000 [RCSI], €0 [Other], (Mar 2011)
Development and evaluation of a novel product to promote ostreogenesis
Lead Applicant : Prof Fergal O'Brien

Funding Agency: SFI
€62352 [RCSI], €0 [Other], (Jan 2011)
CollAqua: Development of a cell and growth factor free naturally-derived osteoinductive bone graft substitute
Lead Applicant : Prof Fergal O'Brien

Funding Agency: EU-FP7
€1999530 [RCSI], €0 [Other], (Dec 2010)
Collagen-based scaffolds for orthopaedic regenerative medicine: applied biomaterials, bioreactor and stem cell technology
Lead Applicant : Prof Fergal O'Brien

Funding Agency: Enterprise Ireland
€395153 [RCSI], €0 [Other], (Oct 2009)
A collagen scaffold-based system for gene and drug delivery to facilitate bone tissue repair (TheraColl)
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: Garry Duffy, John Gleeson - RCSI, Helena Kelly - RCSI, Sonia Partap - RCSI

Funding Agency: Enterprise Ireland
€101405 [RCSI], €0 [Other], (Oct 2009)
Development of a bi-layered cardiac scaffold to enhance the natural stem cell response in cardiovascular disease and the onset of heart failure
Lead Applicant : Dr Garry Duffy
RCSI Co-applicants: Fergal O'Brien

Funding Agency: IRCSET
€227577 [RCSI], €0 [Other], (Jul 2009)
Mechanosensitive primary cilia in osteogenic differentiation of stem cells due to loading
Lead Applicant : Prof Fergal O'Brien

Funding Agency: HRB
€151428 [RCSI], €0 [Other], (Jul 2009)
The in vivo response of engineered collagen-calcium phosphate scaffolds combined with bone morphogenic protein for orthopaedic regenerative medicine.
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: Fergal O'Brien

Funding Agency: Enterprise Ireland
€400271 [RCSI], €0 [Other], (Jul 2009)
Polyphasic collagen-based composite scaffolds for osteochondral defect repair.
Lead Applicant : Dr John Gleeson
RCSI Co-applicants: Fergal O'Brien

Funding Agency: Enterprise Ireland
€84679 [RCSI], €0 [Other], (May 2009)
Novel osteoinductive composite scaffolds for BMP delivery for bone tissue repair
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: John Gleeson

Funding Agency: Enterprise Ireland
€0 [RCSI], €99,640 [Other], (Jul 2008)
Design and development of a novel device to control the fabrication, confined compression and in situ delivery of cell-seeded collagen gel scaffolds
Lead Applicant : Prof Fergal O'Brien
Non RCSI Co-applicants: Danny Kelly - TCD, Kevin Mulhall - UCD

Funding Agency: SFI
€332,932 [RCSI], €0 [Other], (Jul 2008)
IVIS Imaging System Spectrum series.
Lead Applicant : Dr Judy Harmey
RCSI Co-applicants: Fergal O'Brien

Funding Agency: Enterprise Ireland
€81668 [RCSI], €0 [Other], (Jan 2008)
Polyphasic collagen-based composite scaffolds for osteochondral defect repair.
Lead Applicant : Dr John Gleeson
RCSI Co-applicants: Fergal O'Brien

Funding Agency: Enterprise Ireland
€410,841 [RCSI], €0 [Other], (Nov 2007)
HydroxyColl: Collagen-hydroxyapatite composite scaffolds as bone graft substitutes
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: John Gleeson

Funding Agency: SFI
€34,500 [RCSI], €141,000 [Other], (Sep 2007)
The influence of biophysical stimuli on tissue differentiation and matrix synthesis in vitro.
Lead Applicant : Prof Fergal O'Brien
Non RCSI Co-applicants: Danny Kelly (lead PI) - Trinity Centre for Bioengineering, TCD, Veronica Campbell - TCD

Funding Agency: SFI
€210,000 [RCSI], €0 [Other], (Apr 2007)
Computational modelling of the pore structure, permeability and mechanical behaviour of collagen-GAG scaffolds for bone tissue engineering.
Lead Applicant : Prof Fergal O'Brien
Non RCSI Co-applicants: Christian Jungreuthmayer - Siemens

Funding Agency: Enterprise Ireland
€[RCSI], €92,945 [Other], (Nov 2006)
A novel device to control in situ the thermal gelation and concentration of cell-seeded hydrogels
Lead Applicant : Prof Fergal O'Brien
Non RCSI Co-applicants: Danny Kelly - TCD

Funding Agency: SFI
€139,900 [RCSI], €0 [Other], (Nov 2006)
The development of a novel bone graft substitute
Lead Applicant : Prof Fergal O'Brien

Funding Agency: Enterprise Ireland - Proof of Concept
€59,249 [RCSI], €0 [Other], (May 2006)
Collagen-hydroxyapatite composite scaffolding as bone graft substitutes
Lead Applicant : Prof Fergal O'Brien

Funding Agency: IRCSET - Embark Postgraduate Studentship (Niamh Plunkett)
€57,150 [RCSI], €0 [Other], (Nov 2005)
Collagen-calcium phosphate scaffolds for bone tissue engineering
Lead Applicant : Prof Fergal O'Brien

Funding Agency: RCSI - Research Committee Grant  
€90,000 [RCSI], €0 [Other], (Sep 2005)
Development of a bone graft substitute: molecular analysis of osteogenesis by human osteoblasts on a three dimensional collagen scaffold  
Lead Applicant : Dr Jacqueline Daly
RCSI Co-applicants: Fergal O'Brien

Funding Agency: HRB Basic Research Grant
€0 [RCSI], €150,000 [Other], (Sep 2005)
Tissue engineering of cartilage and bone in a hypoxic environment.
Lead Applicant : Prof Fergal O'Brien
Non RCSI Co-applicants: Veronica Campbell - TCD

Funding Agency: HRB
€27,528 [RCSI], €0 [Other], (Jan 2005)
Automatic tissue processor for hystology application
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: Clive Lee

Funding Agency: SFI - PYRA Award
€1,105,929 [RCSI], €0 [Other], (Dec 2004)
Tissue Engineering for Orthopaedic Applications
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: Clive Lee

Funding Agency: HRB Basic Research Grant
€112,800 [RCSI], €0 [Other], (Sep 2004)
The role of microcracks in targeted bone remodelling and their relationship with bone fragility and osteoporosis
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: Clive Lee
Non RCSI Co-applicants: Sue M. Rackard - UCD

Funding Agency: Temple Street Children
€77420 [RCSI], €77420 [Other], (Jun 2004)
Understanding the mechanisms underpinning the influence of age and craniosynostosis on the regenerative capacity of cells & tissues
Lead Applicant : Prof Fergal O'Brien
RCSI Co-applicants: Fergal O'Brien
Non RCSI Co-applicants: Dylan Murray (Lead App) - Temple Street

Research Team
Post-doctoral researchers

Dr Eoghan Cunnane

Dr Alan Hibbitts

Dr Cathal Kearney

Dr Irina Pascu

Mr Le-Ping Yan

Current Students

Emily Ryan (PhD / 3 yrs)

Academic staff

Ms Sarah Casey (Research Programmes Co-ordinat)