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Kavanagh, N.; Ryan, E.J.; Widaa, A.; Sexton, G.; Fennell, J.; O'Rourke, S.; Cahill, K.C.; Kearney, C.J.; O'Brien, F.J. and Kerrigan, S.W. .
Staphylococcal Osteomyelitis: Disease Progression, Treatment Challenges, and Future Directions.
Clinical Microbiology Reviews, 31(2): e00084-17     PMID: 29444953      (Feb 2018)

Curtin, C.M.; Nolan, J.C.; Conlon, R.; Deneweth, L.; Gallagher, C.; Tan, Y.J.; Cavanagh, B.L.; Asraf, A.Z.; Harvey, H.; Miller-Delaney, S.; Shohet, J.; Bray, I.; O'Brien, F.J.; Stallings, R.L. and Psikarev, O. .
A physiologically relevant 3D collagen-based scaffold-neuroblastoma cell system exhibits chemosensitivity similar to orthotopic xenograft models.
Acta Biomaterialia In Press     PMID: 29447961      (Feb 2018)

Kelly, D.J.; O'Brien, F.J. and Prendergast, P.J. .
A short history of bioengineering research in Ireand.
Journal of Biomechanical Engineering, 140(2), 021005-9     PMID: 29260188      (Jan 2018)

Matsiko, A.; Thompson, E.M.; Lloyd-Griffith, C.; Cunniffe, G.M.; Vinardell, T.; Gleeson, J.P.; Kelly, D.J. and O'Brien, F.J. .
An endochondral ossification approach to early-stage bone repair: Use of tissue-engineered hypertrophic cartilage constructs as primordial templates for weight-bearing bone repair.
Journal of Tissue Engineering and Regenerative Medicine, Jan 11. doi: 10.1002/term.2638. Epub ahead of print     PMID: 29327428      (Jan 2018)

Raftery, R.M.; Castano, I.M.; Chen, G.; Cavanagh, B.; Quinn, B.; Curtin, C.M.; Cryan, S.A. and O'Brien, F.J .
Translating the role of osteogenic-angiogenic coupling in bone formation: Highly efficient chitosan-pDNA activated scaffolds can accalerate bone regeration in critical-sized bone defects
Biomaterials, 149: 116-127     PMID: 29024837      (Dec 2017)

Roche, P.; Alekseeva, T.; Widaa, A.; Ryan, A.; Matsiko, A.; Walsh, M.; Duffy, G.P. and O'Brien, F.J. .
Olfactory Derived Stem Cells Delivered in a Biphasic Conduit Promote Peripheral Nerve Repair In Vivo
Stem Cells Transl Med. 2017 Oct;6(10):1894-1904     PMID: 28960910      (Oct 2017)

Curtin, C.M., Castano, I.M. and O'Brien, F.J .
Scaffold-Based microRNA Therapies in Regenerative Medicine and Cancer
Advanced Healthcare Materials. 2017 Oct 25     PMID: 29068566      (Oct 2017)

Caraher, C.M.; Sophocleous, A.; Beattie, J.R.; O'Driscoll, O.; Cummins, N.M.; Brennan, O.; O'Brien, F.J.; Ralston, S.H.; Bell, S.E.J.; Towler, M. and Idris, A.!. .
Raman spectroscopy predicts the link between claw keratin and bone collagen structure in a mouse model of oestrogen deficiency.
Biochimica et Biophysica Acta (BAA) Molecular Basis of Disease, 1864(2): 398-406     PMID: 29066282      (Oct 2017)

Ryan, A.J. Lackington, W.A.; Hibbitts, A.J.; Matheson, A.; Alekseeva, T.; Stejskalova, A.; Roche, P. and O'Brien, F.J. .
A Physicochemically Optimized and Neuroconductive Biphasic Nerve Guidance Conduit for Peripheral Nerve Repair
Adv Healthc Mater. 2017 Oct 4. doi: 10.1002/adhm.201700954.     PMID: 28975768      (Oct 2017)

Barreto, S.; Gonzalez-Vazquez, A.; Cameron, A.R.; O'Brien, F.J. and Murray, D.J. .
Identification of stiffness-induced signalling mechanisms in cells from patent and fused sutures associated with craniosynostosis
Sci Rep. 2017 Sep 13;7(1):11494     PMID: 28904366      (Sep 2017)

Walsh, D.P.; Heise, A.; O'Brien, F.J. and Cryan, S.A. .
An efficient, non-viral dendritic vector for gene delivery in tissue engineering
Gene Therapy. 2017. doi: 10.1038/gt.2017.58     PMID: 28905887      (Sep 2017)

do Amaral, R.J.F.C.; Almeida, H.V.; Kelly, D.J.; O'Brien, F.J. and Kearney, C.J. .
Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy.
Stem Cells International. 2017 Article 6843727     PMID: 29018484      (Sep 2017)

Ryan, A.J.; O'Neill, H.S.; Duffy, G.P. and O'Brien, F.J. .
Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation
Curr Opin Pharmacol. 2017 Aug 30;36:66-71.     PMID: 28865291      (Aug 2017)

Brougham, C.M.; Levingstone, T.J.; Shen, N.; Cooney, G.M.; Jockenhoevel, S.; Flanagan, T.C. and O'Brien, F.J. .
Freeze-drying as a Novel Biofabrication Method for Achieving a Controlled Microarchitecture within Large, Complex Natural Biomaterial Scaffolds.
Advanced Healthcare Materials. 2017. 6(21): 1700598     PMID: 28758358      (Jul 2017)

Gilroy, D.A.; Hobbs, C.; Nicolosi, V.; Buckley, C.T.; O'Brien, F.J. and Kearney, C.J. .
Development of magnetically active scaffolds as intrinsically-deformable bioreactors
MRS Communications. 2017. 7(3): 367-374     PMID: n/a      (Jun 2017)

Brennan O, Sweeney J, O'Meara B, Widaa A, Bonnier F, Byrne HJ, O'Gorman DM, O'Brien FJ. .
A Natural, Calcium-Rich Marine Multi-mineral Complex Preserves Bone Structure, Composition and Strength in an Ovariectomised Rat Model of Osteoporosis.
Calcif Tissue Int. 2017 Jun 24. doi: 10.1007/s00223-017-0299-7. Epub ahead of print     PMID: 28647775      (Jun 2017)

Lebre F, Sridharan R, Sawkins MJ, Kelly DJ, O'Brien FJ, Lavelle EC. .
The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation.
Sci Rep. 2017 Jun 7;7(1):2922. doi: 10.1038/s41598-017-03086-0.     PMID: 28592868      (Jun 2017)

Gonzalez-Fernandez T, Sathy BN, Hobbs C, Cunniffe GM, McCarthy HO, Dunne NJ, Nicolosi V, O'Brien FJ, Kelly DJ. .
Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector.
Acta Biomater. 2017 Jun;55:226-238.     PMID: 28363788      (May 2017)

Laiva AL, O'Brien FJ, Keogh MB. .
Innovations in Gene and Growth Factor delivery systems for Diabetic Wound Healing.
J Tissue Eng Regen Med. 2017 May 8. doi: 10.1002/term.2443. Epub ahead of print Review.     PMID: 28482114      (May 2017)

Davis, N.F.; Cunnane, E.M.; O'Brien, F.J.; Mulvihill, J.J. and Walsh, M.T. .
Tissue engineered extracellular matrices (ECMs) in urology: Evolution and future directions
The Surgeon. 2017. pii: S1479-666X(17)30111-7     PMID: 28811169      (Apr 2017)

Barreto, S.; Gonzale-Vazquez, A.; Cameron, A.R.; Cavanagh, B.; Murray, D.J.; O’Brien, F.J. .
Identification of the mechanisms by which age alters the mechanosensitivity of mesenchymal stromal cells on substrates of differing stiffness: Implications for osteogenesis and angiogenesis.
Acta Biomaterialia Feb 16. pii: S1742-7061(17)30136-8     PMID: 28216301      (Feb 2017)

Cunniffe, G.M.; Díaz-Payno, P.J.; Ramey, J.S.; Mahon, O.R.; Dunne, A.; Thmpson, E.M.; O’Brien, F.J. and Kelly, D.J. .
Growth plate extracellular matrix-derived scaffolds for large bone defect healing.
eCells & Materials 33:130-142. DOI: 10.22203/eCM     PMID: 28197989      (Feb 2017)

O’Leary, C.; O’Brien, F.J. and Cryan, S.A. .
Retinoic Acid-Loaded Collagen-Hyaluronate Scaffolds: A Bioactive Material for Respiratory Tissue Regeneration
ACS Biomaterials Science and Engineering. Accepted Manuscript DOI: 10.1021/acsbiomaterials.6b00561     PMID: .      (Feb 2017)

O'Neill HS, Herron CC, Hastings CL, Deckers R, Lopez Noriega A, Kelly HM, Hennink WE, McDonnell CO, O'Brien FJ, Ruiz-Hernández E, Duffy GP. .
A stimuli responsive liposome loaded hydrogel provides flexible on-demand release of therapeutic agents.
Acta Biomater. 2017 Jan 15;48:110-119.     PMID: 27773752      (Jan 2017)

Almeida H, Sathy BN, Dudurych I, Buckley CT, O'Brien FJ, Kelly DJ. .
Anisotropic Shape-Memory Alginate Scaffolds Functionalized with either Type I or Type II Collagen for Cartilage Tissue Engineering.
Tissue Eng Part A. 2017 Jan;23(1-2):55-68.     PMID: 27712409      (Jan 2017)

Evans, J.C.; Malhotra, M.; Fitzgerald, K.A.; Guo, J.; Cronin, M.F.; Curtin, C. M.; O’Brien, F.J.; Darcy, R. and O’Driscoll, C.M. .
Formulation and evaluation of anisamide-targeted amphiphilic cyclodextrin nanoparticles to promote therapeutic gene silencing in a 3D prostate cancer bone metastases model
Molecular Pharmaceutics 3;14(1):42-52     PMID: 28043128      (Jan 2017)

Lackington, W.A.; Ryan, A. and O’Brien, F.J .
Advances in nerve guidance conduit-based therapeutics for peripheral nerve repair.
ACS Biomaterials Science & Engineering. Accepted Manuscript DOI: 10.1021/acsbiomaterials.6b00500     PMID: .      (Dec 2016)

O'Neill HS, O'Sullivan J, Porteous N, Ruiz Hernandez E, Kelly HM, O'Brien FJ, Duffy GP .
A Collagen Cardiac Patch Incorporating Alginate Microparticles Permits the Controlled Release of HGF and IGF-1 to Enhance Cardiac Stem Cell Migration and Proliferation
Journal of Tissue Engineering and Regenerative Medicine Dec 12. doi: 10.1002/term.2392     PMID: 27943590      (Dec 2016)

Raftery RM, Woods B, Marques AL, Moreira-Silva J, Silva TH, Cryan SA, Reis RL, O'Brien FJ. .
Multifunctional biomaterials from the sea: Assessing the effects of chitosan incorporation into collagen scaffolds on mechanical and biological functionality.
Acta Biomater. 2016 Oct 1;43:160-9.     PMID: 27402181      (Oct 2016)

Cunniffe GM, Curtin CM, Thompson EM, Dickson GR, O'Brien FJ. .
Content-Dependent Osteogenic Response of Nanohydroxyapatite: An in Vitro and in Vivo Assessment within Collagen-Based Scaffolds.
ACS Appl Mater Interfaces. 2016 Sep 14;8(36):23477-88.     PMID: 27537605      (Sep 2016)

Ryan AJ, Brougham CM, Garciarena CD, Kerrigan SW, O'Brien FJ. .
Towards 3D in vitro models for the study of cardiovascular tissues and disease.
Drug Discov Today. 2016 Sep;21(9):1437-45.     PMID: 27117348      (Sep 2016)

Almeida HV, Mulhall KJ, O'Brien FJ, Kelly DJ. .
Stem cells display a donor dependent response to escalating levels of growth factor release from extracellular matrix-derived scaffolds.
J Tissue Eng Regen Med. 2016 Jul 12. doi: 10.1002/term.2199. Epub ahead of print     PMID: 27402022      (Jul 2016)

Raftery RM, Walsh DP, Castaño IM, Heise A, Duffy GP, Cryan SA, O'Brien FJ. .
Delivering nucleic-acid based nanomedicines on biomaterial scaffolds for orthopaedic tissue repair: challenges, progress and future perspectives
Advanced Materials. Jul;28(27):5447-69.     PMID: 26840618      (Jul 2016)

Kearney, C.J.; O’Brien, F.J. and Castro, C. .
DNA Origami: Folded DNA-nanodevices that can direct and interpret cell behavior.
Advanced Materials Jul;28(27):5509-24.     PMID: 26840503      (Jul 2016)

Mencía Castaño I, Curtin CM, Duffy GP, O'Brien FJ. .
Next generation bone tissue engineering: non-viral miR-133a inhibition using collagen-nanohydroxyapatite scaffolds rapidly enhances osteogenesis.
Sci Rep. 2016 Jun 14;6:27941.     PMID: 27297802      (Jun 2016)

O'Neill HS, Gallagher LB, O'Sullivan J, Whyte W, Curley C, Dolan E, Hameed A, O'Dwyer J, Payne C, O'Reilly D, Ruiz-Hernandez E, Roche ET, O'Brien FJ, Cryan SA, Kelly H, Murphy B, Duffy GP. .
Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives.
Adv Mater. 2016 Jul;28(27):5648-61.     PMID: 26840955      (Jun 2016)

Stack JD, Levingstone TJ, Lalor W, Sanders R, Kearney C, O'Brien FJ, David F. .
Repair of large osteochondritis dissecans lesions using a novel multilayered tissue engineered construct in an equine athlete.
J Tissue Eng Regen Med. 2016 May 20. doi: 10.1002/term.2173. Epub ahead of print     PMID: 27198896      (May 2016)

Gonzalez-Fernandez T, Tierney EG, Cunniffe GM, O'Brien FJ, Kelly DJ. .
Gene Delivery of TGF-β3 and BMP2 in an MSC-Laden Alginate Hydrogel for Articular Cartilage and Endochondral Bone Tissue Engineering.
Tissue Eng Part A. 2016 May;22(9-10):776-87.     PMID: 27079852      (May 2016)

Almeida HV, Eswaramoorthy R, Cunniffe GM, Buckley CT, O'Brien FJ, Kelly DJ. .
Fibrin hydrogels functionalized with cartilage extracellular matrix and incorporating freshly isolated stromal cells as an injectable for cartilage regeneration.
Acta Biomater. 2016 May;36:55-62.     PMID: 26961807      (May 2016)

Leszczynska, A.; O’Doherty, A.; Farrell, E.; Pindjakova, J.; O’Brien, F.J.; O’Brien, T.; Barry, F. and Murphy, M. .
Differentiation of vascular stem cells contributes to ectopic calcification of atherosclerotic plaque.
Stem Cells 2016 Apr;34(4):913-23.     PMID: 26840742      (Apr 2016)

Thompson EM, Matsiko A, Kelly DJ, Gleeson J, O'Brien FJ. .
An endochondral ossification-based approach to bone repair: Chondrogenically-primed MSC-laden scaffolds support greater repair of critical-sized cranial defects than osteogenically stimulated constructs in vivo.
Tissue Eng Part A. 2016 Mar; 22(5-6):556-67.     PMID: 26896424      (Mar 2016)

Levingstone TJ, Thompson E, Matsiko A, Schepens A, Gleeson JP, O'Brien FJ. .
Multi-layered collagen-based scaffolds for osteochondral defect repair in rabbits.
Acta Biomater. 2016 Mar 1;32:149-60.     PMID: 26724503      (Mar 2016)

Levingstone, T.J.; Ramesh, A.C; Brady, R.T.; Brama, P.; Kearney, C.; Gleeson, J.P. and O’Brien F.J .
Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints.
Biomaterials 87: 69-81.     PMID: -      (Mar 2016)

O'Leary C, Cavanagh B, Unger RE, Kirkpatrick CJ, O'Dea S, O'Brien FJ, Cryan SA. .
The development of a tissue-engineered tracheobronchial epithelial model using a bilayered collagen-hyaluronate scaffold.
Biomaterials. 2016 Feb 1;85:111-127     PMID: 26871888      (Feb 2016)

Moran, C.J.; Ramesh, A.; Brama, P.A.J.; O’Byrne, J.M.; O’Brien, F.J. and Levingstone, T.J. .
The benefits and limitations of animal models for translational research in cartilage repair.
Journal of Experimental Orthopaedics, Jan 6 3:1     PMID: -      (Jan 2016)

Murphy CM, Duffy GP, Schindeler A, O'Brien FJ. .
Effect of collagen-glycosaminoglycan scaffold pore size on matrix mineralization and cellular behavior in different cell types.
J Biomed Mater Res A. 2016 Jan;104(1):291-304.     PMID: 26386362      (Jan 2016)

Quinlan, E.; Thompson, E.M.; Matsiko, A.; O'Brien, F.J. and López-Noriega, A. .
Functionalization of a collagen-hydroxyapatite scaffold with osteostatin to facilitate enhanced bone regeneration
Advanced Healthcare Materials. Dec;4(17):2649-56     PMID: 26414944      (Dec 2015)

Ryan AJ, O'Brien FJ. .
Insoluble elastin reduces collagen scaffold stiffness, improves viscoelastic properties, and induces a contractile phenotype in smooth muscle cells.
Biomaterials. 2015 Dec;73:296-307     PMID: 26431909      (Dec 2015)

O'Brien FJ, Duffy GP. .
Form and function in regenerative medicine: introduction.
J Anat. 2015 Dec;227(6):705-6. doi: 10.1111/joa.12401     PMID: 26768088      (Dec 2015)

Thompson EM, Matsiko A, Farrell E, Kelly DJ, O'Brien FJ. .
Recapitulating endochondral ossification: a promising route to in vivo bone regeneration.
J Tissue Eng Regen Med. 2015 Aug;9(8):889-902     PMID: 24916192      (Dec 2015)

Mulcahy LE, Curtin CM, McCoy RJ, O'Brien FJ, Taylor D, Lee TC, Duffy GP. .
The effect of bisphosphonate treatment on the biochemical and cellular events during bone remodelling in response to microinjury stimulation.
Eur Cell Mater. 2015 Nov 27;30:271-81.     PMID: 26614482      (Nov 2015)

Cunniffe, G.M.; Vinardell, T.; Thompson, E.; Daly, A.; Matsiko, A.; O’Brien, F.J. and Kelly, D.J. .
Chondrogenically primed mesenchymal stem cell-seeded alginate hydrogels promote early bone formation in critically-sized defects
European Polymer Journal 72: 464-472.     PMID: -      (Nov 2015)

Fitzgerald KA, Guo J, Tierney EG, Curtin CM, Malhotra M, Darcy R, O'Brien FJ, O'Driscoll CM. .
The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics.
Biomaterials. 2015 Oct;66:53-66. doi: 10.1016/j.biomaterials.2015.07.019     PMID: 26196533      (Oct 2015)

Cunniffe GM, Vinardell T, Murphy JM, Thompson EM, Matsiko A, O'Brien FJ, Kelly DJ. .
Porous decellularized tissue engineered hypertrophic cartilage as a scaffold for large bone defect healing.
Acta Biomater. 2015 Sep 1;23:82-90. doi: 10.1016/j.actbio.2015.05.031.     PMID: 26038199      (Sep 2015)

Lloyd-Griffith C, McFadden TM, Duffy GP, Unger RE, James Kirkpatrick C, O'Brien FJ. .
The pre-vascularisation of a collagen-chondroitin sulphate scaffold using human amniotic fluid-derived stem cells to enhance and stabilise endothelial cell-mediated vessel formation.
Acta Biomater. 2015 Aug 20. pii: S1742-7061(15)30074-X.     PMID: 26300337      (Aug 2015)

Brougham CM, Levingstone TJ, Jockenhoevel S, Flanagan TC, O'Brien FJ. .
Incorporation of fibrin into a collagen-glycosaminoglycan matrix results in a scaffold with improved mechanical properties and enhanced capacity to resist cell-mediated contraction.
Acta Biomater. 2015 Aug 19. pii: S1742-7061(15)30066-0.     PMID: 26297884      (Aug 2015)

O’Leary, C.; O’Dea, S.; O’Brien, F.J. and Cryan, S.A. .
Respiratory Tissue Engineering: Current Status and Opportunities for the Future.
Tissue Engineering: Part B 2015 Aug;21(4):323-44.     PMID: 25587703      (Aug 2015)

Fitzgerald KA, Malhotra M, Curtin CM, O' Brien FJ, O' Driscoll CM. .
Life in 3D is never flat: 3D models to optimise drug delivery.
J Control Release. 2015 Jul 26;215:39-54. Review     PMID: 26220617      (Jul 2015)

Raftery RM, Tierney EG, Curtin CM, Cryan SA, O'Brien FJ. .
Development of a gene-activated scaffold platform for tissue engineering applications using chitosan-pDNA nanoparticles on collagen-based scaffolds.
J Control Release. 2015 Jul 28;210:84-94.     PMID: 25982680      (Jul 2015)

Brennan, O.; Stenson, B.J.; O’Gorman, D.M. and O'Brien, F.J. .
Incorporation of the natural marine multi-mineral dietary supplement Aquamin enhances osteogenesis and improves the mechanical properties of a collagen-based bone graft substitute.
Journal of the Mechanical Behavior of Biomedical Materials Jul;47:114-23     PMID: 25884141      (Jul 2015)

do Amaral RJ, Matsiko A, Tomazette MR, Rocha WK, Cordeiro-Spinetti E, Levingstone TJ, Farina M, O'Brien FJ, El-Cheikh MC, Balduino A. .
Platelet-rich plasma releasate differently stimulates cellular commitment toward the chondrogenic lineage according to concentration.
J Tissue Eng. 2015 Jul 7;6:2041731415594127.     PMID: 26380066      (Jul 2015)

Quinlan, E.; Thompson, E.M.; Matsiko, A.; O'Brien, F.J. and López-Noriega, A. .
Long-term controlled delivery of rhBMP-2 from collagen-hydroxyapatite scaffolds for superior bone tissue regeneration
Journal of Controlled Release 2015 Jun;4(8):1175-9     PMID: 25817394      (Jun 2015)

Matsiko, A.; Levingstone, T.J.; Gleeson, J.P. and O'Brien, F.J. .
Incorporation of TGF-Beta 3 within Collagen-Hyaluronic Acid Scaffolds Improves their Chondrogenic Potential.
Adv Healthc Mater. 2015 Jun;4(8):1175-9.     PMID: 25800862      (Jun 2015)

Quinlan, E.; Partap, S.; Azevedo, M.M.; Jell, G.; Stevens, M.M. and O’Brien, F.J. .
Hypoxia-mimicking bioactive glass/collagen glycosaminoglycan composite scaffolds to enhance angiogenesis and bone repair.
Biomaterials Jun;52:358-66     PMID: 25818442      (Jun 2015)

Cunniffe GM, Vinardell T, Mary Murphy J, Thompson EM, Matsiko A, O'Brien FJ, Kelly DJ. .
Porous decellularized tissue engineered hypertrophic cartilage as a scaffold for large bone defect healing.
Acta Biomater. 2015 May 30. pii: S1742-7061(15)00255-X. doi: 10.1016/j.actbio.2015.05.031.     PMID: 26038199      (May 2015)

Sridharan, R.; Cameron, A.R; Kelly, D.J.; Kearney, C. and O'Brien, F.J. .
Biomaterial based modulation of macrophage polarization: A review and suggested design principles.
Materials Today 18(6): 313-325.     PMID: -      (May 2015)

Lloyd-Griffith, C.; Duffy, G.P. and O’Brien, F.J. .
Investigating the effect of hypoxic culture on the endothelial differentiation of human amniotic fluid-derived stem cells.
Journal of Anatomy Dec; 227(6): 767-780.     PMID: 25833670      (Apr 2015)

Lloyd-Griffith C, Duffy GP, O'Brien FJ. .
Investigating the effect of hypoxic culture on the endothelial differentiation of human amniotic fluid-derived stem cells.
J Anat. 2015 Mar 31. doi: 10.1111/joa.12283. Epub ahead of print     PMID: 25833670      (Mar 2015)

Brady RT, O'Brien FJ, Hoey DA. .
Mechanically stimulated bone cells secrete paracrine factors that regulate osteoprogenitor recruitment, proliferation, and differentiation.
Biochem Biophys Res Commun. 2015 Mar 27;459(1):118-23     PMID: http://www.ncbi.nlm.nih.gov/pubmed/25721667      (Mar 2015)

Quinlan E, López-Noriega A, Thompson EM, Hibbitts A, Cryan SA, O'Brien FJ. .
Controlled release of vascular endothelial growth factor from spray-dried alginate microparticles in collagen-hydroxyapatite scaffolds for promoting vascularization and bone repair.
J Tissue Eng Regen Med. 2015 Mar 18. doi: 10.1002/term.2013. Epub ahead of print     PMID: 25783558      (Mar 2015)

Claro T, Kavanagh N, Foster TJ, O'Brien FJ, Kerrigan SW. .
Staphylococcus epidermidis serine-aspartate repeat protein G (SdrG) binds to osteoblast integrin alpha V beta 3.
Microbes Infect. 2015 Mar 5. pii: S1286-4579(15)00037-4.     PMID: 25749709      (Mar 2015)

López-Noriega, A.; Quinlan, E.; Celikkin, N. and O'Brien, F.J. .
Incorporation of polymeric microparticles into collagen-hydroxyapatite scaffolds for the delivery of a pro-osteogenic peptide for bone tissue engineering.
APL Materials: Special Issue on Biomaterials & Bioelectronics     PMID: -      (Mar 2015)

Castaño IM, Curtin CM, Shaw G, Mary Murphy J, Duffy GP, O'Brien FJ. .
A novel collagen-nanohydroxyapatite microRNA-activated scaffold for tissue engineering applications capable of efficient delivery of both miR-mimics and antagomiRs to human mesenchymal stem cells.
J Control Release. 2015 Feb 28;200C:42-51     PMID: 25550154      (Feb 2015)

David, F.; Levingstone, T.J.; de Swarte, M.; Jahns, H.; Gleeson, J.P. and O'Brien, F.J. .
Enhanced bone healing using collagen-hydroxyapatite scaffold implantation in the treatment of a large multiloculated mandibular aneurysmal bone cyst in a Thoroughbred filly
Journal of Tissue Engineering & Regenerative Medicine Oct;9(10):1193-9.     PMID: 25712436      (Feb 2015)

Brady RT, O'Brien FJ, Hoey DA. .
Mechanically stimulated bone cells secrete paracrine factors that regulate Osteoprogenitor recruitment, Proliferation, and differentiation.
Biochem Biophys Res Commun. 2015 Epub ahead of print     PMID: 25721667      (Feb 2015)

Almeida, H.V.; Cunniffe, G.M.; Vinardell, T.; Buckley, C.T.; O’Brien, F.J.; Kelly, D.J. ( .
Coupling freshly isolated CD44+ infrapatellar fat pad derived stromal cells with a TGF-β3 eluting cartilage ECM-derived scaffold as a single stage strategy for promoting chondrogenesis.
Advanced Healthcare Materials 2015 Feb 6. doi: 10.1002/adhm.201400687. Epub ahead of print     PMID: 25656563      (Feb 2015)

Matsiko A, Gleeson J, O'Brien FJ. .
Scaffold mean pore size influences mesenchymal stem cell chondrogenic differentiation and matrix deposition.
Tissue Eng Part A. 2015 Feb;21(3-4):486-97     PMID: 25203687      (Feb 2015)

Quinlan E, López-Noriega A, Thompson E, Kelly HM, Cryan SA, O'Brien FJ .
Development of collagen-hydroxyapatite scaffolds incorporating PLGA and alginate microparticles for the controlled delivery of rhBMP-2 for bone tissue engineering.
J Control Release. 2015 Jan 28;198:71-9.     PMID: 25481441      (Jan 2015)

Curtin CM, Tierney EG, McSorley K, Cryan SA, Duffy GP, O'Brien FJ. .
Combinatorial Gene Therapy Accelerates Bone Regeneration: Non-Viral Dual Delivery of VEGF and BMP2 in a Collagen-Nanohydroxyapatite Scaffold.
Adv Healthc Mater. Jan;4(2):223-7.     PMID: 25125073      (Jan 2015)

Ryan AJ, Gleeson JP, Matsiko A, Thompson EM, O'Brien FJ. .
Effect of different hydroxyapatite incorporation methods on the structural and biological properties of porous collagen scaffolds for bone repair.
J Anat. 2015 Dec; 227(6): 732-745.     PMID: 25409684      (Nov 2014)

Sheridan WS, Ryan AJ, Duffy GP, O'Brien FJ, Murphy BP. .
An Experimental Investigation of the Effect of Mechanical and Biochemical Stimuli on Cell Migration Within a Decellularized Vascular Construct.
Ann Biomed Eng. 2014 Oct;42(10):2029-38.     PMID: 24986334      (Oct 2014)

Groeneveldt LC, Knuth C, Witte-Bouma J, O'Brien FJ, Wolvius EB, Farrell E. .
Enamel Matrix Derivative has No Effect on the Chondrogenic Differentiation of Mesenchymal Stem Cells.
Front Bioeng Biotechnol. 2014 Sep 2;2:29.     PMID: 25229057      (Sep 2014)

Roche ET, Hastings CL, Lewin SA, Shvartsman DE, Brudno Y, Vasilyev NV, O'Brien FJ, Walsh CJ, Duffy GP, Mooney DJ. .
Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart.
Biomaterials. 2014 Aug;35(25):6850-8.     PMID: 24862441      (Aug 2014)

López-Noriega A, Ruiz-Hernández E, Quinlan E, Storm G, Hennink WE, O'Brien FJ. .
Thermally triggered release of a pro-osteogenic peptide from a functionalized collagen-based scaffold using thermosensitive liposomes.
J Control Release 2014 Aug 10;187:158-66     PMID: 24878185      (Aug 2014)

Brennan MA, Haugh MG, O'Brien FJ, McNamara LM .
Estrogen Withdrawal from Osteoblasts and Osteocytes Causes Increased Mineralization and Apoptosis.
Horm Metab Res. 2014 46(08): 537-545     PMID: 24446157      (Jun 2014)

Almeida HV, Liu Y, Cunniffe GM, Mulhall KJ, Matsiko A, Buckley CT, O'Brien FJ, Kelly DJ. .
Controlled release of transforming growth factor-β3 from cartilage-extra-cellular-matrix-derived scaffolds to promote chondrogenesis of human-joint-tissue-derived stem cells.
Acta Biomater. 2014 Jun 4. pii: S1742-7061(14)00242-6     PMID: 24907658      (Jun 2014)

López-Noriega A, Hastings CL, Ozbakir B, O'Donnell KE, O'Brien FJ, Storm G, Hennink WE, Duffy GP, Ruiz-Hernández E. .
Hyperthermia-Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy.
Adv Healthc Mater. 2014 Jun;3(6):854-9.     PMID: 24436226      (Jun 2014)

Murphy CM, Schindeler A, Gleeson JP, Yu NY, Cantrill LC, Mikulec K, Peacock L, O'Brien FJ, Little DG. .
A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates.
Acta Biomater. 2014 May;10(5):2250-8.     PMID: 24456759      (May 2014)

Levingstone TJ, Matsiko A, Dickson G, O'Brien FJ, Gleeson JP. .
A biomimetic multi-layered collagen-based scaffold for osteochondral repair.
Acta Biomater. 2014 May;10(5):1996-2004.     PMID: 24418437      (May 2014)

Widaa A, Brennan O, O'Gorman DM, O'Brien FJ .
The osteogenic potential of the marine-derived multi-mineral formula aquamin is enhanced by the presence of vitamin D.
Phytother Res. 2014 May;28(5):678-84     PMID: 23873476      (May 2014)

Lyons, F.; Gleeson, J.P.; Partap, S. and O'Brien, F.J. .
Novel micro-hydroxyapatite particles in a collagen scaffold: a bioactive bone void filler?
Clin Orthop Relat Res. 2014 Apr;472(4):1318-28.     PMID: 24385037      (Apr 2014)

Brennan MA, Gleeson JP, O'Brien FJ, McNamara LM. .
Effects of ageing, prolonged estrogen deficiency and zoledronate on bone tissue mineral distribution.
J Mech Behav Biomed Mater. 2014 Jan;29:161-70.     PMID: 24090875      (Jan 2014)

McFadden TM, Duffy GP, Allen AB, Stevens HY, Schwarzmaier SM, Plesnila N, Murphy MJ, Barry FP, Guldberg RE, O'Brien FJ .
The delayed addition of human mesenchymal stem cells to pre-formed endothelial cell networks results in functional vascularization of a collagen-glycosaminoglycan scaffold in vivo.
Acta Biomater. 2013 Dec; 9(12):9303-16.     PMID: 23958783      (Dec 2013)

McCoy RJ, Widaa A, Watters KM, Wuerstle M, Stallings RL, Duffy GP, O'Brien FJ. .
Orchestrating osteogenic differentiation of mesenchymal stem cells - identification of placental growth factor as a mechanosensitive gene with a pro-osteogenic role.
Stem Cells. 2013 Nov;31(11):2420-31.     PMID: 23897668      (Nov 2013)

Murphy CM, O'Brien FJ, Little DG, Schindeler A. .
Cell-scaffold interactions in the bone tissue engineering triad.
Eur Cell Mater. 2013 Sep 20;26:120-32     PMID: 24052425      (Sep 2013)

Holland JC, Brennan O, Kennedy OD, Mahony NJ, Rackard S, O'Brien FJ, Lee TC. .
Examination of osteoarthritis and subchondral bone alterations within the stifle joint of an ovariectomised ovine model.
J Anat. 2013 Jun222(6):588-97     PMID: 23634692      (Jun 2013)

Raftery R, O'Brien FJ, Cryan SA. .
Chitosan for gene delivery and orthopedic tissue engineering applications.
Molecules. 2013 May 1518(5):5611-47.     PMID: 23676471      (May 2013)

Tierney EG, Duffy GP, Cryan SA, Curtin CM, O'Brien FJ. .
Non-viral gene-activated matrices- next generation constructs for bone repair.
Organogenesis. 2013 Jan 19(1)     PMID: 23538777      (Apr 2013)

Matsiko A, Levingstone TJ, O'Brien FJ. .
Advanced strategies for articular cartilage defect repair
Materials 6: 637-668. Review.     PMID: -      (Mar 2013)

Tierney, E.G. McSorley, K. Hastings, C.L. Cryan, S.A. Murphy, M.J. Barry, F.P. O’Brien, T. O’Brien, F.J. and Duffy, G.P. .
High levels of ephrinB2 over-expression increases the osteogenic differentiation of human mesenchymal stem cells & promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinB2 gene-activated matrix
Journal of Controlled Release Feb 10165(3):173-82.     PMID: 23201622      (Feb 2013)

Holland JC, Brennan O, Kennedy OD, Rackard SM, O'Brien FJ, Lee TC. .
Subchondral osteopenia and accelerated bone remodelling post-ovariectomy - a possible mechanism for subchondral microfractures in the aetiology of spontaneous osteonecrosis of the knee?
Journal of Anatomy Feb 222(2):231-8.     PMID: 23171138      (Feb 2013)

Claro T, Widaa A, McDonnell C, Foster TJ, O'Brien FJ, Kerrigan SW. .
Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and release of interleukin-6 in bone infection.
Microbiology. 2013 Jan;159(Pt 1):147-54     PMID: 23154968      (Jan 2013)

McCoy RJ, O'Brien FJ. .
Visualizing feasible operating ranges within tissue engineering systems using a "windows of operation" approach: A perfusion-scaffold bioreactor case study.
Biotechnol Bioeng. 2012 Dec 109(12):3161-71.     PMID: 22627891      (Dec 2012)

Brennan, O Kuliwaba, J.S. Lee, T.C. Parkinson, I.H. Fazzalari, N.L. McNamara, L.M. and O’Brien, F.J .
Temporal changes in bone composition, architecture and strength following estrogen deficiency in osteoporosis.
Calcified Tissue International 2012 Dec 91(6):440-9     PMID: 23076448      (Dec 2012)

Hoey DA, Tormey S, Ramcharan S, O'Brien FJ, Jacobs CR. .
Primary Cilia Mediated Mechanotransduction in Human Mesenchymal Stem Cells.
Stem Cells. Nov; 30(11):2561-70.     PMID: 22969057      (Nov 2012)

Widaa A, Claro T, Foster TJ, O'Brien FJ, Kerrigan SW. .
Staphylococcus aureus Protein A Plays a Critical Role in Mediating Bone Destruction and Bone Loss in Osteomyelitis.
PLoS One. 2012;7(7):e40586     PMID: 22792377      (Jul 2012)

Hastings CL, Kelly HM, Murphy MJ, Barry FP, O'Brien FJ, Duffy GP. .
Development of a thermoresponsive chitosan gel combined with human mesenchymal stem cells and desferrioxamine as a multimodal pro-angiogenic therapeutic for the treatment of critical limb ischaemia.
J Control Release. 2012 Jul 10;161(1):73-80. Epub 2012 Apr 27.     PMID: 22562065      (Jul 2012)

Murphy, C.M.; Matsiko, A.; Haugh, M.G.; Gleeson J.P. and O'Brien, F.J. .
Mesenchymal stem cell fate is regulated by the composition and mechanical properties of collagen-glycosaminoglycan scaffolds.
J Mech Behav Biomed Mater. 2012 Jul;11:53-62.     PMID: 22658154      (Jul 2012)

Matsiko, A. Levingstone, T.J. O'Brien, F.J. and Gleeson J.P. .
Addition of hyaluronic acid improves cellular infiltration and promotes early-stage chondrogenesis in a collagen-based scaffold for cartilage tissue engineering.
J Mech Behav Biomed Mater. 2012 Jul11:41-52.     PMID: 22658153      (Jul 2012)

O'Brien FJ, Harley BA. .
Editorial: Special Issue on Tissue Engineering
J Mech Behav Biomed Mater. 2012 Jul;11:1-2     PMID: 22658149      (Jun 2012)

McCoy RJ, Jungreuthmayer C, O'Brien FJ. .
Influence of flow rate and scaffold pore size on cell behavior during mechanical stimulation in a flow perfusion bioreactor.
Biotechnol Bioeng. 2012 Jun109(6):1583-94     PMID: 22249971      (Jun 2012)

Lim Fat D, Kennedy J, Galvin R, O'Brien F, Mc Grath F, Mullett H. .
The Hounsfield value for cortical bone geometry in the proximal humerus-an in vitro study.
Skeletal Radiol. May;41(5):557-68.     PMID: 21932054      (May 2012)

Presbitero G, O'Brien FJ, Lee TC, Taylor D. .
Distribution of microcrack lengths in bone in vivo and in vitro.
J Theor Biol. 2012 304C:164-171.     PMID: 22498804      (Apr 2012)

Tierney EG, Duffy GP, Hibbitts AJ, Cryan SA, O'Brien FJ. .
The development of non-viral gene-activated matrices for bone regeneration using polyethyleneimine (PEI) and collagen-based scaffolds.
J Control Release. 2012 Mar 10;158(2):304-11.     PMID: 22138069      (Apr 2012)

Alhag M, Farrell E, Toner M, Lee TC, O'Brien FJ, Claffey N. .
Evaluation of the ability of collagen-glycosaminoglycan scaffolds with or without mesenchymal stem cells to heal bone defects in Wistar rats.
Oral Maxillofac Surg. 2012 Mar;16(1):47-55     PMID: 21968608      (Mar 2012)

Curtin, C.; Lyons, F.; Cunniffe, G.M.; Duffy, G.P. and O’Brien, F.J. .
Innovative collagen nano-hydroxyapatite based scaffolds offer a highly efficient non-viral gene delivery platform for stem cell-mediated bone repair.
Advanced Materials 2012; 24(6):749-54.     PMID: 22213347      (Feb 2012)

Brennan O, O'Brien FJ, McNamara LM. .
Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro.
Horm Metab Res. 2012 Feb;44(2):154.     PMID: 22314335      (Feb 2012)

O'Gorman DM, Tierney CM, Brennan O, O'Brien FJ. .
The Marine-derived, Multi-mineral formula, Aquamin, Enhances Mineralisation of Osteoblast Cells In Vitro.
Phytother Res. 2011 Jul 12. doi: 10.1002/ptr.3561.     PMID: 21751268      (Jul 2011)

Holland JC, Brennan O, Kennedy OD, Rackard SM, O'Brien FJ, Lee TC. .
Subchondral trabecular structural changes in the proximal tibia in an ovine model of increased bone turnover.
J Anat. 2011 Jun;218(6):619-24     PMID: 21477184      (Jun 2011)

Brennan MA, Gleeson JP, Browne M, O'Brien FJ, Thurner PJ, McNamara LM. .
Site specific increase in heterogeneity of trabecular bone tissue mineral during oestrogen deficiency.
Eur Cell Mater. 2011 May 15;21:396-406.     PMID: 21574136      (May 2011)

Keogh MB, Partap S, Daly JS, O'Brien FJ. .
Three hours of perfusion culture prior to 28 days of static culture, enhances osteogenesis by human cells in a collagen GAG scaffold.
Biotechnol Bioeng. 2011 May;108(5):1203-10.     PMID: 21165906      (May 2011)

Haugh MG, Murphy CM, McKiernan RC, Altenbuchner C, O'Brien FJ. .
Crosslinking and mechanical properties significantly influence cell attachment, proliferation and migration within collagen glycosaminoglycan scaffolds.
Tissue Eng Part A. 2011 May;17(9-10):1201-8.     PMID: 21155630      (May 2011)

Claro T, Widaa A, O'Seaghdha M, Miajlovic H, Foster TJ, O'Brien FJ, Kerrigan SW. .
Staphylococcus aureus Protein A Binds to Osteoblasts and Triggers Signals That Weaken Bone in Osteomyelitis.
PLoS One. 2011 Apr 15;6(4):e18748.     PMID: 21525984      (Apr 2011)

O'Brien FJ .
Biomaterials and scaffolds for tissue engineering.
Materials Today 14: 32-39. Review.     PMID: -      (Apr 2011)

Cunniffe, G.M. and O'Brien, F.J. .
Collagen scaffolds for orthopedic regenerative medicine.
JOM: Journal of the Minerals, Metals and Materials Society. 63(4): 66-73. Review.     PMID: -      (Apr 2011)

Alhag M, Farrell E, Toner M, Claffey N, Lee TC, O'Brien F. .
Evaluation of early healing events around mesenchymal stem cell-seeded collagen-glycosaminoglycan scaffold. An experimental study in Wistar rats.
Oral Maxillofac Surg. 2011 Mar;15(1):31-9     PMID: 20644972      (Mar 2011)

Duffy GP, McFadden TM, Byrne EM, Gill SL, Farrell E, O'Brien FJ. .
Towards in vitro vascularisation of collagen-GAG scaffolds.
Eur Cell Mater. 2011;21:15-30.     PMID: 21225592      (Mar 2011)

Brennan O, O'Brien FJ, McNamara LM. .
Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro.
Horm Metab Res. 2012;44(2):154     PMID: 22314335      (Feb 2011)

Brennan O, Kennedy OD, Lee TC, Rackard SM, O'Brien FJ, McNamara LM. .
The effects of estrogen deficiency and bisphosphonate treatment on tissue mineralisation and stiffness in an ovine model of osteoporosis.
J Biomech. 2010; 44(3):386-90.     PMID: 21093863      (Feb 2011)

Plunkett N, O'Brien FJ. .
Bioreactors in tissue engineering.
Technol Health Care. 2011 19(1):55-69.     PMID: 21248413      (Jan 2011)

Farrell E, Both S, Odorfer KI, Koevoet W, Kops N, O'Brien FJ, Baatenburg de Jong RJ, Verhaar JA, Cuijpers V, Jansen J, Erben RG, van Osch GJ. .
In-vivo generation of bone via endochondral ossification by in-vitro chondrogenic priming of adult human and rat mesenchymal stem cells.
BMC Musculoskelet Disord. 2011 Jan 31;12(1):31.     PMID: 21281488      (Jan 2011)

Cunniffe GM, O'Brien FJ, Partap S, Levingstone TJ, Stanton KT, Dickson GR. .
The synthesis and characterization of nanophase hydroxyapatite using a novel dispersant-aided precipitation method.
J Biomed Mater Res A. 2010 95A (4):1142-1149.     PMID: 20878985      (Dec 2010)

Gleeson JP, Plunkett NA, O’Brien FJ. .
Addition of hydroxyapatite improves stiffness, interconnectivity and osteogenic potential of a highly porous collagen-based scaffold for bone tissue regeneration
eCells and Materials 2010; 20: 218-230.     PMID: 20922667      (Dec 2010)

Lyons FG, Al-Munajjed AA, Kieran SM, Toner ME, Murphy CM, Duffy GP, O'Brien FJ. .
The healing of bony defects by cell-free collagen-based scaffolds compared to stem cell-seeded tissue engineered constructs.
Biomaterials. 2010; 31(35):9232-43.     PMID: 20863559      (Dec 2010)

Partap S, Lyons F, O'Brien FJ. .
Scaffolds & surfaces
Stud Health Technol Inform. 2010;152:187-201.     PMID: 20407195      (Dec 2010)

McCoy RJ, O'Brien FJ. .
Influence of shear stress in perfusion bioreactor cultures for the development of 3d bone tissue constructs: a review.
Tissue Eng Part B Rev. 2010 16(6): 577-585.     PMID: 20799909      (Dec 2010)

Keogh MB, O'Brien FJ, Daly JS. .
Substrate stiffness and contractile behaviour modulate the functional maturation of osteoblasts on a collagen-GAG scaffold.
Acta Biomater. 2010 6(11):4305-13.     PMID: 20570642      (Nov 2010)

Haugh MG, Murphy CM, O'Brien FJ. .
Novel Freeze-drying Methods to Produce a Range of Collagen-GAG scaffolds with Tailored Mean Pores Sizes.
Tissue Eng Part C Methods. 2010 Oct;16(5):887-94.     PMID: 19903089      (Oct 2010)

Brennan O, Kennedy OD, Lee TC, Rackard SM, O'Brien FJ. .
Effects of estrogen deficiency and bisphosphonate therapy on osteocyte viability and microdamage accumulation in an ovine model of osteoporosis.
J Orthop Res. 2011 Mar;29(3):419-24.     PMID: 20886644      (Sep 2010)

Thorpe SD, Buckley CT, Vinardell T, O'Brien FJ, Campbell VA, Kelly DJ. .
The response of bone marrow-derived mesenchymal stem cells to dynamic compression following TGF-beta3 induced chondrogenic differentiation.
Ann Biomed Eng. 2010 38(9):2896-909.     PMID: 20458627      (Sep 2010)

Khayyeri H, Checa S, Tägil M, O'Brien FJ, Prendergast PJ. .
Tissue differentiation in an in vivo bioreactor: in silico investigations of scaffold stiffness.
J Mater Sci Mater Med. 2010 Aug;21(8):2331-6.     PMID: 20037774      (Aug 2010)

Cunniffe GM, Dickson GR, Partap S, Stanton KT, O'Brien FJ. .
Development and characterisation of a collagen nano-hydroxyapatite composite scaffold for bone tissue engineering.
J Mater Sci Mater Med. 2010 ;21(8):2293-8.     PMID: 20091099      (Aug 2010)

Murphy CM, O'Brien FJ. .
Understanding the effect of mean pore size on cell activity in collagen-glycosaminoglycan scaffolds
Cell Adh Migr. 2010 Jul 9;4(3). [Epub ahead of print]     PMID: 20421733      (Jul 2010)

Stops, A.J.; Harrison, N.M.; Haugh, M.G.; O'Brien, F.J. and McHugh, P.E. .
Local and regional mechanical characterisation of a collagen-glycosaminoglycan scaffold using high-resolution finite element analysis.
Journal of the Mechanical Behavior of Biomedical Materials 2010 May; 3(4):292-302.     PMID: 20346897      (May 2010)

Plunkett N, O'Brien FJ. .
Bioreactors in tissue engineering.
Stud Health Technol Inform. 2010;152:214-30.     PMID: 20407197      (May 2010)

Keogh MB, O'Brien FJ, Daly JS .
A novel collagen scaffold supports human osteogenesis-applications for bone tissue engineering.
Cell and Tissue Research. 2010 Apr;340(1): 169-177.     PMID: 20198386      (Apr 2010)

Plunkett NA, Partap S, O'Brien FJ. .
Osteoblast response to rest periods during bioreactor culture of collagen-glycosaminoglycan scaffolds.
Tissue Eng Part A. 2010 16(3):943-51     PMID: 19827912      (Mar 2010)

Stops AJ, Heraty KB, Browne M, O'Brien FJ, McHugh PE. .
A prediction of cell differentiation and proliferation within a collagen-glycosaminoglycan scaffold subjected to mechanical strain and perfusive fluid flow.
J Biomech. 2009 Mar 3; 43(4):618-26.     PMID: 19939388      (Mar 2010)

Healy C, Kennedy OD, Brennan O, Rackard SM, O'Brien FJ, Lee TC. .
Structural adaptation and intracortical bone turnover in an ovine model of osteoporosis.
J Orthop Res. 2010 Feb;28(2):248-51.     PMID: 19725098      (Feb 2010)

Murphy CM, Haugh MG, O'Brien FJ .
The effect of mean pore size on cell attachment, proliferation and migration in collagen glycosaminoglycan scaffolds for tissue engineering.
Biomaterials. 2010 31: 461–466.     PMID: 19819008      (Jan 2010)

Partap S, Plunkett NA, Kelly DJ, O'Brien FJ. .
Stimulation of osteoblasts using rest periods during bioreactor culture on collagen-glycosaminoglycan scaffolds.
J Mater Sci Mater Med. 2010 Aug;21(8):2325-30.     PMID: 20091098      (Jan 2010)

Buckley CT, Thorpe SD, O'Brien FJ, Robinson AJ, Kelly DJ. .
The effect of concentration, thermal history and cell seeding density on the initial mechanical properties of agarose hydrogels.
J Mech Behav Biomed Mater. 2009 Oct;2(5):512-21.     PMID: 19627858      (Oct 2009)

Tierney CM, Jaasma MJ, O'Brien FJ. .
Osteoblast activity on collagen-GAG scaffolds is affected by collagen and GAG concentrations.
J Biomed Mater Res A. 2009 Sep 2 91A(1):92-101     PMID: 18767061      (Oct 2009)

Al-Munajjed AA, Plunkett NA, Gleeson JP, Weber T, Jungreuthmayer C, Levingstone T, Hammer J, O'Brien FJ. .
Development of a biomimetic collagen-hydroxyapatite scaffold for bone tissue engineering using a SBF immersion technique.
J Biomed Mater Res B Appl Biomater. 2009 Aug; 90(2):584-91.     PMID: 19180526      (Aug 2009)

Farrell E, van der Jagt OP, Koevoet W, Kops N, van Manen CJ, Hellingman CA, Jahr H, O'Brien FJ, Verhaar JA, Weinans H, van Osch GJ. .
Chondrogenic Priming of Human Bone Marrow Stromal Cells: A Better Route to Bone Repair?
Tissue Eng Part C Methods. 2009 Jun;15(2):285-95.     PMID: 19108678      (Jun 2009)

Jungreuthmayer C, Jaasma MJ, Al-Munajjed AA, Zanghellini J, Kelly DJ, O'Brien FJ. .
Deformation simulation of cells seeded on a collagen-GAG scaffold in a flow perfusion bioreactor
Med Eng Phys. 2009 May;31(4):420-427.     PMID: 19109048      (May 2009)

Kennedy OD, Brennan O, Rackard SM, O'Brien FJ, Taylor D, Lee Tc. .
Variation of trabecular microarchitectural parameters in cranial, caudal and mid-vertebral regions of the ovine L3 vertebra. Journal of Anatomy 214: 729–735.
J Anat. 2009 214: 729–735.     PMID: 122352275      (May 2009)

Jungreuthmayer C, Donahue SW, Jaasma MJ, Al-Munajjed AA, Zanghellini J, Kelly DJ, O'Brien FJ. .
A Comparative Study of Shear Stresses in Collagen-Glycosaminoglycan and Calcium Phosphate Scaffolds in Bone Tissue-Engineering Bioreactors.
Tissue Eng Part A. 2009 15(5):1141-1149.     PMID: 18831686      (May 2009)

Haugh MG, Jaasma MJ, O'Brien FJ. .
The effect of dehydrothermal treatment on the mechanical and structural properties of collagen-GAG scaffolds.
J Biomed Mater Res A. 2009 May;89(2):363-9.     PMID: 18431763      (May 2009)

Al-Munajjed, A.A., O'Brien, F.J. .
Influence of a novel calcium-phosphate coating on the mechanical properties of highly porous collagen scaffolds for bone repair
J Mech Behav Biomed Mater. 2009 (2) 138-146.     PMID: 12345678      (Apr 2009)

Tierney, C.M., Haugh, M.G., Liedl, J., Mulcahy, F., Hayes, B., O'Brien, F.J. .
The effects of collagen concentration and crosslink density on the biological, structural and mechanical properties of collagen-GAG scaffolds for bone tissue engineering
J Mech Behav Biomed Mater. 2009 (2)202-209.     PMID: 12345678      (Mar 2009)

Brennan O, Kennedy OD, Lee TC, Rackard SM, O'Brien FJ. .
Biomechanical properties across trabeculae from the proximal femur of normal and ovariectomised sheep.
J Biomech. 2009 Mar 11;42(4):498-503.     PMID: 19171344      (Mar 2009)

Kennedy OD, Brennan O, Rackard SM, Staines A, O'Brien FJ, Taylor D, Lee TC. .
Effects of ovariectomy on bone turnover, porosity, and biomechanical properties in ovine compact bone 12 months postsurgery.
J Orthop Res. 2009. 27(3):303-309.     PMID: 18853433      (Mar 2009)

Thorpe SD, Buckley CT, Vinardel T, O'Brien FJ, Campbell VA, Kelly DJ. .
Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells.
Biochem Biophys Res Commun. 2008 Dec 12;377(2):458-62.     PMID: 18851955      (Dec 2008)

Kennedy OD, Brennan O, Mauer P, Rackard SM, O'Brien FJ, Taylor D, Lee TC. .
The effects of increased intracortical remodeling on microcrack behaviour in compact bone.
Bone. 2008 Oct; (43) 889-893     PMID: 18706535      (Nov 2008)

Byrne EM, Farrell E, McMahon LA, Haugh MG, O'Brien FJ, Campbell VA, Prendergast PJ, O'Connell BC. .
Gene expression by marrow stromal cells in a porous collagen-glycosaminoglycan scaffold is affected by pore size and mechanical stimulation.
J Mater Sci Mater Med. 2008 Nov; 19(11):3455-63.     PMID: 18584120      (Nov 2008)

Kennedy OD, Brennan O, Mahony NJ, Rackard SM, O'Brien FJ, Taylor D, Lee CT. .
Effects of high bone turnover on the biomechanical properties of the L3 vertebra in an ovine m0del of early stage osteoporosis’
Spine. 2008 Nov 1;33(23):2518-23.     PMID: 18978592      (Nov 2008)

McMahon LA, O'Brien FJ, Prendergast PJ. .
Biomechanics and mechanobiology in osteochondral tissues.PMID:
Regen Med. 2008 Sep;3(5):743-59.     PMID: 18729798      (Sep 2008)

Harrison NM, McDonnell PF, O'Mahoney DC, Kennedy OD, O'Brien FJ, McHugh PE. .
Heterogeneous linear elastic trabecular bone modelling using micro-CT attenuation data and experimentally measured heterogeneous tissue properties.
J Biomech. 2008 41(11):2589-96.     PMID: 18602110      (Jul 2008)

Farrell E, Wielopolski P, Pavljasevic P, van Tiel S, Jahr H, Verhaar J, Weinans H, Krestin G, O'Brien FJ, van Osch G, Bernsen M. .
Effects of iron oxide incorporation for long term cell tracking on MSC differentiation in vitro and in vivo.
Biochem Biophys Res Commun. 2008 May 16;369(4):1076-81.     PMID: 18336785      (May 2008)

Jaasma MJ, O'Brien FJ. .
Mechanical Stimulation of Osteoblasts Using Steady and Dynamic Fluid Flow
Tissue Eng Part A. 2008 Apr 23; 14(7): 1213-1223.     PMID: 18433309      (Apr 2008)

Jaasma MJ, Plunkett NA, O'Brien FJ .
Design and validation of a dynamic flow perfusion bioreactor for use with compliant tissue engineering scaffolds.
J Biotech. 2008; 133: 490-496.     PMID: 18221813      (Feb 2008)

Kennedy OD, Brennan O, Mauer P, O'Brien FJ, Rackard SM, Taylor D, Lee TC. .
The behaviour of fatigue-induced microdamage in compact bone samples from control and ovariectomised sheep.
Stud Health Technol Inform. 2008; 133:148-55.     PMID: 18376023      (Feb 2008)

Al-Munajjed, A.; Gleeson, J.P. and O'Brien, F.J. .
Development of a collagen calcium-phosphate scaffold as a novel bone graft substitute
Stud Health Technol Inform. 2008; 133:11-20.     PMID: 18376009      (Jan 2008)

Keeley BJ, Heidari B, Mahony NJ, Rackard SM, O'Brien FJ, Lee TC, Brennan O, Kennedy OD, Fitzpatrick D. .
Biomechanical comparison of the pullout properties of external skeletal fixation pins in the tibiae of intact and ovariectomised ewes.
Vet Comp Orthop Traumatol. 2008;21(5):418-26.     PMID: 19011705      (Jan 2008)

O'Brien, F.J.; Taylor, D. and Lee, T.C. .
Bone as a composite material: the role of osteons as barriers to crack growth in compact bone.
International Journal of Fatigue (Invited Article) 2007 (29): 1051–1056.     PMID: JIJF1695      (Jun 2007)

Taylor D, Hazenberg J, O'Brien FJ, Lee TC. .
How does bone detect cracks? Jaasma MJ, Plunkett NA, O'Brien FJ
Key Engineering Materials 2007; 348-349: 57-60     PMID: N/A      (Jun 2007)

Farrell E, Byrne EM, Fischer J, O'Brien FJ, O'Connell BC, Prendergast PJ, Campbell VA. .
A comparison of the osteogenic potential of adult rat mesenchymal stem cells cultured in 2-D and on 3-D collagen glycosaminoglycan scaffolds.
Technol Health Care. 2007;15(1):19-31.     PMID: 17264410      (Jan 2007)

O'Brien FJ, Harley BA, Waller MA, Yannas IV, Gibson LJ, Prendergast PJ. .
The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering.
Technol Health Care. 2007;15(1):3-17.     PMID: 17264409      (Jan 2007)

Lee TC, O'Brien FJ, Gunnlaugsson T, Parkesh R, Taylor D. .
Microdamage and bone mechanobiology.
Technol Health Care. 2006;14(4-5):359-65.     PMID: 17065757      (Jul 2006)

Mohsin S, O'Brien FJ, Lee TC. .
Microcracks in compact bone: a three-dimensional view.
J Anat. 2006 Jul;209(1):119-24.     PMID: 16822275      (Jul 2006)

Farrell E, O'Brien FJ, Doyle P, Fischer J, Yannas I, Harley BA, O'Connell B, Prendergast PJ, Campbell VA. .
A collagen-glycosaminoglycan scaffold supports adult rat mesenchymal stem cell differentiation along osteogenic and chondrogenic routes.
Tissue Eng. 2006 Mar;12(3):459-68     PMID: 16579679      (Mar 2006)

Mohsin S, O'Brien FJ, Lee TC .
Osteonal crack barriers in ovine compact bone.
J Anat. 2006; 208(1):81-9     PMID: 16420381      (Jan 2006)

O'Brien FJ, Brennan O, Kennedy OD, Lee TC .
Microcracks in cortical bone: how do they affect bone biology?
Curr Osteoporos Rep. 2005; 3(2):39-45     PMID: 16036100      (Jun 2005)

O'Brien FJ, Taylor D, Clive Lee T .
The effect of bone microstructure on the initiation and growth of microcracks.
J Orthop Res. 2005; 23(2):475-80     PMID: 15734265      (Mar 2005)

O'Brien F J, Hardiman DA, Hazenberg JG, Mercy MV, Mohsin S, Taylor D, Lee TC .
The behaviour of microcracks in compact bone.
Eur J Morphol. 2005; 42(1-2):71-9     PMID: 16123026      (Feb 2005)

O'Brien FJ, Harley BA, Yannas IV, Gibson LJ .
The effect of pore size on cell adhesion in collagen-GAG scaffolds.
Biomaterials. 2005; 26(4):433-41     PMID: 15275817      (Feb 2005)

Moore TL, O'Brien FJ, Gibson LJ .
Creep does not contribute to fatigue in bovine trabecular bone.
J Biomech Eng. 2004; 126(3):321-9     PMID: 15341168      (Jun 2004)

O'Brien FJ, Harley BA, Yannas IV, Gibson L .
Influence of freezing rate on pore structure in freeze-dried collagen-GAG scaffolds.
Biomaterials. 2004; 25(6):1077-86     PMID: 14615173      (Mar 2004)

Lee TC, Mohsin S, Taylor D, Parkesh R, Gunnlaugsson T, O'Brien FJ, Giehl M, Gowin W .
Detecting microdamage in bone.
J Anat. 2003; 203(2):161-72     PMID: 12924817      (Aug 2003)

O'Brien FJ, Taylor D, Lee TC .
Microcrack accumulation at different intervals during fatigue testing of compact bone.
J Biomech 2003;36(7):973-80     PMID: 12757806      (Jul 2003)

Taylor D, O'Brien F, Lee TC .
A theoretical model for the simulation of microdamage accumulation and repair in compact bone.
Meccanica 2000; 3179: 1-10.     PMID: N/A      (Jul 2002)

O'Brien FJ, Taylor D, Lee TC .
An improved labelling technique for monitoring microcrack growth in compact bone.
J Biomech 2002; 35(4):523-6     PMID: 11934422      (Apr 2002)

Taylor D, Falsetti F, O'Brien FJ, O'Reilly P, Banville E, Lee TC .
A fatigue based model of disuse osteoporosis.
Computer Methods in Biomechanics and Biomedical Engineering 2001; 4: 413-420     PMID: N/A      (Jan 2001)

Lee TC, O'Brien FJ, Taylor D .
The nature of fatigue damage in bone.
International Journal of Fatigue 2000; 22: 847-853.     PMID: N/A      (Nov 2000)

O'Brien FJ, Taylor D, Dickson GR, Lee TC .
Visualisation of three-dimensional microcracks in compact bone.
J Anat. 2000; 197(3):413-20     PMID: 11117627      (Oct 2000)

Taylor D, O'Brien F, Prina-Mello A, Ryan C, O'Reilly P, Lee TC .
Compression data on bovine bone confirms that a "stressed volume" principle explains the variability of fatigue strength results.
J Biomech 1999;32(11):1199-203     PMID: 10541070      (Nov 1999)