Project Title Project Description Leading PI Co investigators Funding Source
Advanced scaffold-based therapeutics to facilitate nerve regeneration Click here for Project Description O'Brien Fergal, RCSI William Lackington, DCU Irish Research Council PhD Studentship Programme
Identification of mechanotransdutive signalling mechanisms associated with age and craniosynostosis with a view to developing advanced bone regeneration strategies Click here for Project Description O'Brien Fergal, RCSI - Irish Research Council Postdoctoral Fellowship
The Development of Placental Growth Factor-Functionalised, Collagen-Based Scaffolds for Promoting Vascularisation and Bone Repair Click here for Project Description O'Brien Fergal, RCSI - Irish Research Council Postdoctoral Fellowship
Development of a bone graft substitute: molecular analysis of osteogenesis by human osteoblasts on a three dimensional collagen scaffold   Daly Jacqueline, RCSI Fergal O'Brien, RCSI RCSI - Research Committee Grant
Novel osteoinductive composite scaffolds for BMP delivery for bone tissue repair Click here for Project Description O'Brien Fergal, RCSI John Gleeson, RCSI Enterprise Ireland Proof of Concept
Collagen-hydroxyapatite composite scaffolds as bone graft substitutes (HydroxyColl) Click here for Project Description O'Brien Fergal, RCSI John Gleeson, RCSI Enterprise Ireland Commercialisation fund
Polyphasic collagen-based composite scaffolds for osteochondral defect repair. Click here for Project Description Gleeson John, RCSI Fergal O'Brien, RCSI Enterprise Ireland Commercilatisation fund
In vitro vascularisation of scaffolds for bone repair using a Human Dermal Microvascular Endothelial cell (HDMEC)/ Human Amniotic Fluid-Derived Stem Cell (AFSC) co-culture system Click here for Project Description O'Brien Fergal, RCSI - EMBO Travel Grant
Understanding the mechanisms underpinning the influence of age and craniosynostosis on the regenerative capacity of cells & tissues   O'Brien Fergal, RCSI Dylan Murray (Lead App), Temple Street
Fergal O'Brien, RCSI
Temple Street Children NOT APPLICABLE
Digital epifluorescence microscope with high resolution camera system and image analysis workstation   O'Brien Fergal, RCSI VA Campbell, TCD
Judy Harmey, RCSI
Caroline Jefferies, RCSI
D Kelly, TCD
SFI Equipment Grant
CollAqua: Development of a cell and growth factor free naturally-derived osteoinductive bone graft substitute Click here for Project Description O'Brien Fergal, RCSI - SFI TIDA - Technology innovation Development Award
Endothelial dysfunction in severe blood stream infection Click here for Project Description Kerrigan Steve, RCSI Timothy Foster, TCD
Philip Cummins, DCU
Hilary Humphreys, RCSI
Fergal O'Brien, RCSI
Raymond Stallings, RCSI
SFI Career Development Award
Collagen-hydroxyapatite composite scaffolding as bone graft substitutes Click here for Project Description O'Brien Fergal, RCSI - Enterprise Ireland - Proof of Concept
Collagen-calcium phosphate scaffolds for bone tissue engineering Click here for Project Description O'Brien Fergal, RCSI - IRCSET - Embark Postgraduate Studentship (Niamh Plunkett)
The influence of annealing on the pore size of collagen-GAG scaffolds Click here for Project Description O'Brien Fergal, RCSI - SFI UREKA
Student summer placement   O'Brien Fergal, RCSI - SFI - Ureka supplement
Development of a bi-layered scaffold to enhance the natural cardiac stem cell response in cardiovascular disease and the onset of heart failure. Click here for Project Description Duffy Garry, RCSI Fergal O'Brien, RCSI Enterprise Ireland Proof of Concept
HydroxyColl: A novel scaffold for bone repair Click here for Project Description O'Brien Fergal, RCSI John Gleeson, RCSI Enterprise Ireland Action Erasmus Multilateral Projects
Polyphasic collagen-based composite scaffolds for osteochondral defect repair. Click here for Project Description Gleeson John, RCSI Fergal O'Brien, RCSI Enterprise Ireland Commercialisation fund
A collagen scaffold-based system for gene and drug delivery to facilitate bone tissue repair (TheraColl) Click here for Project Description O'Brien Fergal, RCSI Garry Duffy, RCSI
John Gleeson, RCSI
Helena Kelly, RCSI
Sonia Partap, RCSI
Enterprise Ireland Technology Development
The influence of biophysical stimuli on tissue differentiation and matrix synthesis in vitro. Click here for Project Description O'Brien Fergal, RCSI Danny Kelly (lead PI), Trinity Centre for Bioengineering, TCD
Veronica Campbell, TCD
SFI Research Frontiers Programme
IVIS Imaging System Spectrum series. Click here for Project Description Harmey Judy, RCSI Fergal O'Brien, RCSI SFI Equipment Grant
Bone Tissue Mineralisation During Osteoporosis Click here for Project Description O'Brien Fergal, RCSI Laoise McNamara, University of Southhampton HRB Project Grant
Development and evaluation of a novel product to promote ostreogenesis Click here for Project Description O'Brien Fergal, RCSI - Private Donor NOT APPLICABLE
Development of a bioreactor test platform to analyse performance of a novel heart valve scaffold. Click here for Project Description O'Brien Fergal, RCSI - IHF NOT APPLICABLE
Bone regeneration using stem cell-directed endochondral ossification Click here for Project Description O'Brien Fergal, RCSI John Gleeson, RCSI HRB Health Research Award
Development of Bioactive Therapeutics Harnessing Stem Cell Mechanobiology Click here for Project Description O'Brien Fergal, RCSI Dylan Murray, Temple St Hospital
Andrew Cameron, RCSI
Raymond Stallings, RCSI
HRB Health Research Award
CardioColl Stage II Click here for Project Description Duffy Garry, RCSI Bruce Murphy, Trinity College Dublin
Fergal O'Brien, RCSI
Enterprise Ireland Commercialisation fund
Automatic tissue processor for hystology application   O'Brien Fergal, RCSI Clive Lee, RCSI HRB Equipment Grant
A recombinant approach to cell-matrix interactions and vascular tissue engineering Click here for Project Description O'Brien Fergal, RCSI Sarah Heilshorn, Stanford University
Matthew Haugh, NUIG
Irish Research Council Elevate Postdoctoral Fellowship
Development of Novel Collagen-based Bone and Osteochondral Graft Substitutes for New Surgical Indications of Use Click here for Project Description O'Brien Fergal, RCSI John Gleeson, SurgaColl Technologies
John Gleeson, RCSI
Enterprise Ireland Innovation partnership
Mechanosensitive primary cilia in osteogenic differentiation of stem cells due to loading Click here for Project Description O'Brien Fergal, RCSI - IRCSET Post-doctoral Fellowship
Computational modelling of the pore structure, permeability and mechanical behaviour of collagen-GAG scaffolds for bone tissue engineering. Click here for Project Description O'Brien Fergal, RCSI Christian Jungreuthmayer, Siemens SFI Industry Research Partnership
Collagen-based scaffolds for orthopaedic regenerative medicine: applied biomaterials, bioreactor and stem cell technology Click here for Project Description O'Brien Fergal, RCSI - EU-FP7 Starting Independent Research Grant
Advanced Materials and Bioengineering Research (AMBER) Centre Click here for Project Description O'Brien Fergal, RCSI John Boland, TCD
Michael Coey, TCD
Jonathan Coleman, TCD
Georg Duesberg, TCD
Michael Morris, UCC
Justin Holmes, UCC
Stefano Sanvito, TCD
Daniel Kelly, TCD
Garry Duffy, RCSI
John O'Byrne, RCSI
SFI Research Centre
The in vivo response of engineered collagen-calcium phosphate scaffolds combined with bone morphogenic protein for orthopaedic regenerative medicine. Click here for Project Description O'Brien Fergal, RCSI Fergal O'Brien, RCSI HRB Clinical Research Training Fellowship
The development of a novel bone graft substitute Click here for Project Description O'Brien Fergal, RCSI - SFI Research Frontiers Programme
Development of a novel collagen-based film for corneal repair Click here for Project Description O'Brien Fergal, RCSI Martin Clynes, DCU
Finbarr O, DCU
SFI TIDA - Technology innovation Development Award
The Development of a Novel Construct for Peripheral Nerve Repair Click here for Project Description O'Brien Fergal, RCSI Phoebe Roche, RCSI
Michael Walsh, RCSI
Simon Archibald, Integra LifeSciences
SFI TIDA - Technology innovation Development Award
Collaboration with Crescent Diagnostics Click here for Project Description O'Brien Fergal, RCSI - Crescent Diagnostics NOT APPLICABLE
The role of microcracks in targeted bone remodelling and their relationship with bone fragility and osteoporosis Click here for Project Description O'Brien Fergal, RCSI Clive Lee, RCSI
Sue M. Rackard, UCD
HRB Basic Research Grant
Investigating the in vivo potential of pre-vascularised collagen based scaffolds for bone tissue regeneration Click here for Project Description O'Brien Fergal, RCSI Guldberg Robert, Georgia Institute of Technology SFI Travel Grant
Development of a bi-layered cardiac scaffold to enhance the natural stem cell response in cardiovascular disease and the onset of heart failure Click here for Project Description Duffy Garry, RCSI Fergal O'Brien, RCSI Enterprise Ireland Proof of Concept
Tissue engineering for orthopaedic applications: the use of collagen scaffolds for the development of bone graft substitutes. Click here for Project Description O'Brien Fergal, RCSI Clive Lee, RCSI SFI - PYRA Award
Tissue engineering of cartilage and bone in a hypoxic environment. Click here for Project Description O'Brien Fergal, RCSI Veronica Campbell, TCD HRB Basic Research Grant
Is the bone tissue mineralization process altered during osteoporosis? Click here for Project Description O'Brien Fergal, RCSI Laoise McNamara (Lead PI), Trinity Centre for Bioengineering SFI Research Frontiers Programme
Development of a cannabinoid-eluting scaffold for orthopaedic tissue engineering strategies   O'Brien Fergal, RCSI VA Campbell, TCD SFI Research Frontiers Programme
Design and development of a novel device to control the fabrication, confined compression and in situ delivery of cell-seeded collagen gel scaffolds   O'Brien Fergal, RCSI Danny Kelly, TCD
K Mulhall,
Kevin Mulhall, UCD
Enterprise Ireland Commercialisation fund
Natural ECM derived injectable microparticles for regeneration of the intervertebral disc (DiscReGen)   O'Brien Fergal, RCSI Fergal O'Brien, RCSI
Conor Buckley (Lead App), TCD
Enterprise Ireland NOT APPLICABLE
A novel bioactive scaffold for articular cartilage regeneration   O'Brien Fergal, RCSI Fergal O'Brien, RCSI
Daniel Kelly (Lead App),
Enterprise Ireland NOT APPLICABLE
A novel device to control in situ the thermal gelation and concentration of cell-seeded hydrogels Click here for Project Description O'Brien Fergal, RCSI Danny Kelly, TCD Enterprise Ireland