Tissue Regeneration: TERG utilises biomaterials expertise to develop construct and living system technologies that can restore the structural & functional properties of damaged or degenerated tissues including bone, cartilage, cornea, vascular tissue, heart valves, respiratory tissue and nerves.
Targeted Bio-therapeutic Delivery Platforms: Our scaffolds are also being developed into targeted drug delivery platforms through the incorporation of bio-therapeutics such as drugs, proteins, peptides, and nucleic acids, thereby accelerating the healing capacity of these constructs. Furthermore, TERG is pursuing the development of novel non-viral delivery vectors such as nano-hydroxyapatite, chitosan and PEI that can be used independently or in conjunction with the collagen-based scaffolds to enhance gene or nucleic acid delivery to cells.
Image credit: Irene Mencía Castano
In-vitro Model Systems of Disease: The dynamic interaction between bacteria and bone cells during infection is being elucidated by using our collagen-based scaffolds to create a simplified in-vitro model system of bone. Additionally, the incorporation of calcium phosphates into these collagen-based scaffolds is being used to gain insight into the behaviour of breast carcinoma cells in pseudo un-mineralised and mineralised environments.
Expanding fundamental understanding in mechanobiology: TERG is specifically interested in identifying genes that are mechanically augmented in response to shear stress and how these genes subsequently regulate the recruitment and differentiation of cell subsets that are crucial to bone formation and resorption processes. Furthermore, we are interested in elucidating how the mechanosensitivity of these cells is altered in disease states such as osteoporosis.