contact details

Associate Professor of Human Genetics
Molecular & Cellular Therapeutics, RCSI

123 St Stephens Green, Dublin 2
Telephone: +353 (0)1 402 2146

Department Secretary: Anne Grady
Telephone: +353 (0)1 402 2420


2011: Postgraduate Diploma in Leadership and Management Development (for Researchers), International School of Healthcare Management, RCSI, Dublin, Ireland. Leadership and Management

2006: PhD Human Genetics, University College London. Epilepsy genetics and pharmacogenetics

2000: BA Genetics, Trinity College Dublin. Population Genetics


2017 to date: Deputy Director, Science Foundation Ireland FutureNeuro Research Centre of Excellence

2017 to date: Honorary Secretary, The Irish Society of Human Genetics

2016 to date: Associate Professor of Human Genetics, School of Medicine, Dept. of Molecular and Cellular Therapeutics, RCSI, Dublin

2014 to date: Deputy Director, School of Postgraduate Studies, RCSI, Dublin

2013 to 2016: Senior Lecturer in Human Genetics, School of Medicine, Dept. of Molecular and Cellular Therapeutics, RCSI, Dublin

2008 to 2013: Biomedical Research Lecturer, School of Medicine, Dept. of Molecular and Cellular Therapeutics, RCSI, Dublin

2006 to 2008: Research Lecturer,, School of Medicine, Dept. of Molecular and Cellular Therapeutics, RCSI, Dublin

2005 to 2006: Post Doctoral Research Scientist, Duke University Institute for Genome Sciences and Policy

2002 to 2005: PhD student, University College London, Gower St, London, UK

2000 to 2002: Research Scientist, Stanford University, Palo Alto, California, USA

academic activity

1. Coordinator of Molecular Medicine Module (5 ECTS), Undergraduate Medicine

2. Coordinator of Molecular Medicine Module (5 ECTS), Graduate Entry Medicine

summary of research career to date

Gianpiero Cavalleri is Associate Professor of Human Genetics, Deputy Director of the SFI FutureNeuro Research Centre and Director of the Human Genetic Variation Research Group, one of the largest human genetics research groups in Ireland. Prof. Cavalleri is also Deputy Director of the School of Postgraduate Studies at RCSI. Gianpiero received his Ph.D. in human genetics at University College London in 2006. Prior to his arrival at RCSI, he worked at the Institute for Genome Science and Policy at Duke University, North Carolina. He was appointed to faculty at RCSI in 2008. Prof. Cavalleri has published over 100 articles in leading peer reviewed international journals including Nature, Nature Genetics, PNAS and the New England Journal of Medicine. A feature of his research is its diversity, and his research group works at the interface of computational biology, clinical research and human evolution.

research interests

Prof. Cavalleri’s research programme at RCSI focuses on developing methods to understand the genetic component to complex traits in humans, in particular those related to the development and treatment of sporadic forms of epilepsy. He is a Principal Investigator within the SFI FutureNeuro Research Centre. He is also involved in a variety of additional projects that use the latest genetic techniques, to help inform donor-recipient matches to improve outcome of organ transplantation, and to understand how the hypoxic environment at high altitude in the Himalaya has shaped the genomes of indigenous individuals of the region.

research areas

Neuroscience, Neurological diseases


Irish Society of Human Genetics (2012)

American Society of Human Genetics (2010)

European Society of Human Genetics (2008)

Epidemiology and Public Health Nucleus for the European Association for Cardiovascular Prevention and Rehabilitation (2006-2010)


2014: Career Development Award, Science Foundation Ireland

Personal Links

International Collaborations

Sanjay Sisodiya, Univerity College London, UK ; David Goldstein, Duke University, USA ; Kevin Shianna, Duke University, USA ; Michael Weale, Kings College London, UK ; Chantal Depondt, University Libre de Bruxelles, Belgium ; Nicholas Wood, Univerity College London, UK
Genetics and pharmacogenetics of epilepsy
(Jun 2006)

Hugh Montgomery, University College London, UK ; Peter Robbins, Oxford University, UK ; Michael Weale, Kings College London, UK ; Michael Tam, Chinese University of Hong Kong, Hong Kong ; Gao Yang, Beijing Genomics Institute, China ; Chen Chen, Beijing Genomics Institute, China ; Kevin Shianna, Duke University, USA
The genetics of high altitude adaptation
(Jun 2006)

Peer Reviewed Publications

Hernandez-Fuentes M, Stapleton CP, Cavalleri GL, Conlon P, Weale ME, Lord GM; United Kingdom and Ireland Renal Transplant Consortium (UKIRTC)
The genetic determinants of renal allograft rejection.
Am J Transplant. 2018 May 2. doi: 10.1111/ajt.14909. Epub ahead of print     PMID: 29719114     (May 2018)

Whelan CD, et al
Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study.
Brain. 2018 Feb 1;141(2):391-408. doi: 10.1093/brain/awx341.     PMID: 29365066     (Feb 2018)

McCormack M, Gui H, ... International League Against Epilepsy Consortium on Complex Epilepsies;, Cavalleri GL.
Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.
Neurology. 2018 Jan 23;90(4):e332-e341. doi: 10.1212/WNL.0000000000004853. Epub 2017 Dec 29.     PMID: 29288229     (Jan 2018)

Gilbert E, O'Reilly S, Merrigan M, McGettigan D, Molloy AM, Brody LC, Bodmer W, Hutnik K, Ennis S, Lawson DJ, Wilson JF, Cavalleri GL.
The Irish DNA Atlas: Revealing Fine-Scale Population Structure and History within Ireland.
Sci Rep. 2017 Dec 8;7(1):17199. doi: 10.1038/s41598-017-17124-4.     PMID: 29222464     (Dec 2017)

Androsova G, Krause R, Borghei M, Wassenaar M, Auce P, Avbersek A, Becker F, Berghuis B, Campbell E, Coppola A, Francis B, Wolking S, Cavalleri GL, Craig J, Delanty N, Koeleman BPC, Kunz WS, Lerche H, Marson AG, Sander JW, Sills GJ, Striano P, Zara F, Sisodiya SM, Depondt C; EpiPGX Consortium.
Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis.
Epilepsia. 2017 Oct;58(10):1734-1741. doi: 10.1111/epi.13871. Epub 2017 Aug 31.     PMID: 28857179     (Oct 2017)

Berghuis B, van der Palen J, de Haan GJ, Lindhout D, Koeleman BPC, Sander JW; EpiPGX Consortium.
Carbamazepine- and oxcarbazepine-induced hyponatremia in people with epilepsy.
Epilepsia. 2017 Jul;58(7):1227-1233. doi: 10.1111/epi.13777. Epub 2017 May 24.     PMID: 28542738     (Jul 2017)

Gilbert E, Carmi S, Ennis S, Wilson JF, Cavalleri GL.
Genomic insights into the population structure and history of the Irish Travellers.
Sci Rep. 2017 Feb 9;7:42187. doi: 10.1038/srep42187.     PMID: 28181990     (Feb 2017)

Whelan CD, Altmann A, Botía JA, Jahanshad N,..., Cavalleri GL.....Thompson PM, Sisodiya SM.
Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study.
Brain. 2018 Feb 1;141(2):391-408. doi: 10.1093/brain/awx341     PMID: 29365066     (Feb 2017)

Hibar DP, Adams HHH, Jahanshad N, et al
Novel genetic loci associated with hippocampal volume.
Nat Commun. 2017 Jan 18;8:13624. doi: 10.1038/ncomms13624.     PMID: 28098162     (Jan 2017)

Cole AM, Cox S, Jeong C, Petousi N, Aryal DR, Droma Y, Hanaoka M, Ota M, Kobayashi N, Gasparini P, Montgomery H, Robbins P, Di Rienzo A, Cavalleri GL.
Genetic structure in the Sherpa and neighboring Nepalese populations.
BMC Genomics. 2017 Jan 19;18(1):102. doi: 10.1186/s12864-016-3469-5.     PMID: 28103797     (Jan 2017)

Adams HH, Hibar DP, et al
Novel genetic loci underlying human intracranial volume identified through genome-wide association.
Nat Neurosci. 2016 Dec;19(12):1569-1582. doi: 10.1038/nn.4398. Epub 2016 Oct 3.     PMID: 27694991     (Dec 2016)

Toomey S, Madden SF, Furney SJ, Fan Y, McCormack M, Stapleton C, Cremona M, Cavalleri GL, Milewska M, Elster N, Carr A, Fay J, Kay EW, Kennedy S, Crown J, Gallagher WM, Hennessy BT, Eustace AJ.
The impact of ERBB-family germline single nucleotide polymorphisms on survival response to adjuvant trastuzumab treatment in HER2-positive breast cancer.
Oncotarget. 2016 Nov 15;7(46):75518-75525. doi: 10.18632/oncotarget.12782.     PMID: 27776352     (Nov 2016)

Lazaridis I, Nadel D, Rollefson G, Merrett DC, ...Cavalleri G, Comas D, Froguel P, Gilbert E, Kerr SM, Kovacs P, Krause J, McGettigan D, Merrigan M, Merriwether DA, O'Reilly S, Richards MB, Semino O, Shamoon-Pour M, Stefanescu G, Stumvoll M, Tönjes A, Torroni A, Wilson JF, Yengo L, Hovhannisyan NA, Patterson N, Pinhasi R, Reich D.
Genomic insights into the origin of farming in the ancient Near East.
Nature. 2016 Aug 25;536(7617):419-24. Epub 2016 Jul 25.     PMID: 27459054     (Aug 2016)

Alhusaini S, Whelan CD, Doherty CP, Delanty N, Fitzsimons M, Cavalleri GL.
Temporal Cortex Morphology in Mesial Temporal Lobe Epilepsy Patients and Their Asymptomatic Siblings.
Cereb Cortex. 2016 Mar;26(3):1234-41. doi: 10.1093/cercor/bhu315. Epub 2015 Jan 9.     PMID: 25576532     (Mar 2016)

Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJE, Arias-Vasquez A, Smoller JW, Nichols TE, Neale MC, McIntosh AM, Lee P, McMahon FJ, Meyer-Lindenberg A, Mattheisen M, Andreassen OA, Gruber O, Sachdev PS, Roiz-Santiañez R, Saykin AJ, Ehrlich S, Mather KA, Turner JA, Schwarz E, Thalamuthu A, Shugart YY, Ho YY, Martin NG, Wright MJ; Schizophrenia Working Group of the Psychiatric Genomics Consortium; ENIGMA Consortium, O'Donovan MC, Thompson PM, Neale BM, Medland SE, Sullivan PF.
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.
Nat Neurosci. 2016 Mar;19(3):420-431. doi: 10.1038/nn.4228. Epub 2016 Feb 1.     PMID: 26854805     (Mar 2016)

Hallast P, Batini C, Zadik D, Maisano Delser P, Wetton JH, Arroyo-Pardo E, Cavalleri GL, de Knijff P, Destro Bisol G, Dupuy BM, Eriksen HA, Jorde LB, King TE, Larmuseau MH, López de Munain A, López-Parra AM, Loutradis A, Milasin J, Novelletto A, Pamjav H, Sajantila A, Schempp W, Sears M, Tolun A, Tyler-Smith C, Van Geystelen A, Watkins S, Winney B, Jobling MA.
The Y-chromosome tree bursts into leaf: 13,000 high-confidence SNPs covering the majority of known clades.
Mol Biol Evol. 2015 Mar;32(3):661-73. doi: 10.1093/molbev/msu327. Epub 2014 Dec 2.     PMID: 25468874     (Mar 2015)

McCarthy NS, Vangjeli C, Cavalleri GL, Delanty N, Shianna KV, Surendran P, O'Brien E, Munroe PB, Masca N, Tomaszewski M, Samani NJ, Stanton AV.
Two further blood pressure loci identified in ion channel genes with a gene-centric approach.
Circ Cardiovasc Genet. 2014 Dec;7(6):873-9. doi: 10.1161/CIRCGENETICS.113.000190. Epub 2014 Sep 10.     PMID: 25210050     (Dec 2014)

Cole AM, Petousi N, Cavalleri GL, Robbins PA.
Genetic variation in SENP1 and ANP32D as predictors of chronic mountain sickness.
High Alt Med Biol. 2014 Dec;15(4):497-9. doi: 10.1089/ham.2014.1036.     PMID: 25225945     (Dec 2014)

International League Against Epilepsy Consortium on Complex Epilepsies.
Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies.
Lancet Neurol. 2014 Sep;13(9):893-903. doi: 10.1016/S1474-4422(14)70171-1. Epub 2014 Jul 30.     PMID: 25087078     (Sep 2014)

Edwards LM, Sigurdsson MI, Robbins PA, Weale ME, Cavalleri GL, Montgomery HE, Thiele I.
Genome-scale methods converge on key mitochondrial genes for the survival of human cardiomyocytes in hypoxia.
Circ Cardiovasc Genet. 2014 Aug;7(4):407-15. doi: 10.1161/CIRCGENETICS.113.000269. Epub 2014 May 29.     PMID: 24873932     (Aug 2014)

Thompson PM, Stein JL, et al
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data.
Brain Imaging Behav. 2014 Jun;8(2):153-82. doi: 10.1007/s11682-013-9269-5. Review.     PMID: 24399358     (Jun 2014)

Gómez-Herreros F, Schuurs-Hoeijmakers JH, McCormack M, Greally MT, Rulten S, Romero-Granados R, Counihan TJ, Chaila E, Conroy J, Ennis S, Delanty N, Cortés-Ledesma F, de Brouwer AP, Cavalleri GL, El-Khamisy SF, de Vries BB, Caldecott KW.
TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.
Nat Genet. 2014 May;46(5):516-21. doi: 10.1038/ng.2929. Epub 2014 Mar 23.     PMID: 24658003     (May 2014)

Petousi N, Croft QP, Cavalleri GL, Cheng HY, Formenti F, Ishida K, Lunn D, McCormack M, Shianna KV, Talbot NP, Ratcliffe PJ, Robbins PA.
Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia.
J Appl Physiol (1985). 2014 Apr 1;116(7):893-904. doi: 10.1152/japplphysiol.00535.2013. Epub 2013 Sep 12.     PMID: 24030663     (Apr 2014)

Chukwu J, Delanty N, Webb D, Cavalleri GL.
Weight change, genetics and antiepileptic drugs.
Expert Rev Clin Pharmacol. 2014 Jan;7(1):43-51. doi: 10.1586/17512433.2014.857599. Epub 2013 Dec 2. Review.     PMID: 24308788     (Jan 2014)

Kasperaviciute D, Catarino CB, Matarin M, ..... Cavalleri GL, Kunz WS, Sisodiya SM.
Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A.
Brain. 2013 Oct;136(Pt 10):3140-50. doi: 10.1093/brain/awt233. Epub 2013 Sep 6.     PMID: 24014518     (Oct 2013)

Genetic signatures reveal high-altitude adaptation in a set of ethiopian populations.
Huerta-Sánchez E, Degiorgio M, Pagani L, Tarekegn A, Ekong R, Antao T, Cardona A, Montgomery HE, Cavalleri GL, Robbins PA, Weale ME, Bradman N, Bekele E, Kivisild T, Tyler-Smith C, Nielsen R.
Mol Biol Evol. 2013 Aug;30(8):1877-88. doi: 10.1093/molbev/mst089. Epub 2013 May 10.     PMID: 23666210     (Aug 2013)

Alhusaini S, Scanlon C, Ronan L, Maguire S, Meaney JF, Fagan AJ, Boyle G, Borgulya G, Iyer PM, Brennan P, Costello D, Chaila E, Fitzsimons M, Doherty CP, Delanty N, Cavalleri GL.
Heritability of subcortical volumetric traits in mesial temporal lobe epilepsy.
PLoS One. 2013 Apr 23;8(4):e61880. doi: 10.1371/journal.pone.0061880. Print 2013.     PMID: 23626743     (Apr 2013)

Scanlon C, Ronan L, Doherty CP, Cavalleri GL, Tirupati S, Alhusaini S, Maguire S, Delanty N, Iyer PM, Chaila E, Fitzsimons M.
MRI-based brain structure volumes in temporal lobe epilepsy patients and their unaffected siblings: a preliminary study.
J Neuroimaging. 2013 Jan;23(1):64-70. doi: 10.1111/j.1552-6569.2012.00736.x. Epub 2012 Aug 28.     PMID: 22928655     (Jan 2013)

Heinzen EL, Depondt C, Cavalleri GL, Ruzzo EK, Walley NM, Need AC, Ge D, He M, Cirulli ET, Zhao Q, Cronin KD, Gumbs CE, Campbell CR, Hong LK, Maia JM, Shianna KV, McCormack M, Radtke RA, O'Conner GD, Mikati MA, Gallentine WB, Husain AM, Sinha SR, Chinthapalli K, Puranam RS, McNamara JO, Ottman R, Sisodiya SM, Delanty N, Goldstein DB
Exome Sequencing Followed by Large-Scale Genotyping Fails to Identify Single Rare Variants of Large Effect in Idiopathic Generalized Epilepsy.
Am J Hum Genet. 2012 Aug 1.     PMID: 22863189     (Aug 2012)

Alhusaini S, Doherty CP, Palaniyappan L, Scanlon C, Maguire S, Brennan P, Delanty N, Fitzsimons M, Cavalleri GL.
Asymmetric cortical surface area and morphology changes in mesial temporal lobe epilepsy with hippocampal sclerosis.
Epilepsia. 2012 Jun;53(6):995-1003     PMID: 22510097     (Apr 2012)

McCormack M, Urban TJ, Shianna KV, Walley N, Pandolfo M, Depondt C, Chaila E, O'Conner GD, Kasperavičiūtė D, Radtke RA, Heinzen EL, Sisodiya SM, Delanty N, Cavalleri GL.
Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions.
Pharmacogenomics. 2012 Mar;13(4):399-405. doi: 10.2217/pgs.11.165.     PMID: 22379998     (Mar 2012)

Alhusaini S, Doherty CP, Scanlon C, Ronan L, Maguire S, Borgulya G, Brennan P, Delanty N, Fitzsimons M, Cavalleri GL.
A cross-sectional MRI study of brain regional atrophy and clinical characteristics of temporal lobe epilepsy with hippocampal sclerosis.
Epilepsy Res. 2012 Mar;99(1-2):156-66. doi: 10.1016/j.eplepsyres.2011.11.005. Epub 2011 Dec 23.     PMID: 22197033     (Dec 2011)

McCormack M, Alfirevic A, Bourgeois S, Farrell JJ, Kasperavičiūtė D, Carrington M, Sills GJ, Marson T, Jia X, de Bakker PI, Chinthapalli K, Molokhia M, Johnson MR, O'Connor GD, Chaila E, Alhusaini S, Shianna KV, Radtke RA, Heinzen EL, Walley N, Pandolfo M, Pichler W, Park BK, Depondt C, Sisodiya SM, Goldstein DB, Deloukas P, Delanty N, Cavalleri GL, Pirmohamed M
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.
N Engl J Med. 2011 Mar 24;364(12):1134-43.     PMID: 21428769     (Mar 2011)

Kasperaviciûte D, Catarino CB, Heinzen EL, Depondt C, Cavalleri GL, Caboclo LO, Tate SK, Jamnadas-Khoda J, et al
Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.
Brain     PMID:     (Jul 2010)

Beall CM, Cavalleri GL, Deng L, Elston RC, Gao Y, Knight J, Li C, Li JC, Liang Y, McCormack M, Montgomery HE, Pan H, Robbins PA, Shianna KV, Tam SC, Tsering N, Veeramah KR, Wang W, Wangdui P, Weale ME, Xu Y, Xu Z, Yang L, Zaman MJ, Zeng C, Zhang L, Zhang X, Zhaxi P, Zheng YT.
Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders.
PNAS     PMID: 20534544     (Jun 2010)

O'Dushlaine CT, Morris D, Moskvina V, Kirov G, Consortium IS, Gill M, Corvin A, Wilson JF, Cavalleri GL.
Population structure and genome-wide patterns of variation in Ireland and Britain.
EJHG     PMID: 20571510     (Jun 2010)

Heinzen EL, Radtke RA, Urban TJ, Cavalleri GL, et al
Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes.
Am J Hum Genet     PMID: 20398883     (May 2010)

Petrovski S, Scheffer IE, Sisodiya SM, O'Brien TJ, Berkovic SF; EPIGEN Consortium.
Lack of replication of association between scn1a SNP and febrile seizures.
Neurology     PMID: 19949041     (Dec 2009)

Kuper H, Nicholson A, Kivimaki M, Aitsi-Selmi A, Cavalleri G, Deanfield JE, Heuschmann P, Jouven X, Malyutina S, Mayosi BM, Sans S, Thomsen T, Witteman JC, Hingorani AD, Lawlor DA, Hemingway H.
Evaluating the causal relevance of diverse risk markers: horizontal systematic review.
BMJ     PMID: 19892791     (Nov 2009)

Lynch JM, Tate SK, Kinirons P, Weale ME, Cavalleri GL, Depondt C, Murphy K, O'Rourke D, Doherty CP, Shianna KV, Wood NW, Sander JW, Delanty N, Goldstein DB, Sisodiya SM.
No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy.
Epilepsy Res.     PMID: 18977120     (Oct 2009)

Lynch JM, Tate SK, Kinirons P, Weale ME, Cavalleri GL, Depondt C, Murphy K, O'Rourke D, Doherty CP, Shianna KV, Wood NW, Sander JW, Delanty N, Goldstein DB, Sisodiya SM.
No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy.
Epilepsy Res     PMID: 18977120     (Jan 2009)

C. Verzilli, T. Shah, J. P. Casas, J. Chapman, M. Sandhu, S. L. Debenham, M. Boekholdt, K.T. Khaw, N. J. Wareham R. Judson, E. J. Benjamin, S. Kathiresan, M. G. Larson, J. Rong, R. Sofat, S. E. Humphries, L. Smeeth, G. L. Cavalleri, J. C. Whittaker, A. D. Hingorani.
Bayesian meta analysis of genetic association studies with different sets of markers.
Am J Hum Genet     PMID: 18394581     (Apr 2008)

C. T. O’Dushlaine, C. Dolan, M. E. Weale, A. Stanton, D. T. Croke, R. Kalviainen, S. M. Sisodiya, M. Gill, A. P. Corvin, D. W. Morris, N. Delanty and G. L. Cavalleri.
An assessment of the Irish population for large-scale genetic mapping studies.
The European Journal of Human Genetics     PMID: 17971835     (Feb 2008)

G. L. Cavalleri, M. E. Weale, K. V. Shianna, R. Singh, J. M. Lynch, B. Grinton, C. Szoeke, K. Murphy, P. Kinirons, D. O’Rourke, D. Ge, C. Depondt, K. G. Claeys, M. Pandolfo, C. Gumbs, N. Walley, J. McNamara, J. C. Mulley, K. N. Linney, L. J. Sheffield, R. A. Radtke, S. K. Tate, S. L.Chissoe, R.l A. Gibson, D. Hosford, A. Stanton, T. D. Graves, M. G. Hanna, K. Eriksson, A. Kantanen, R. Kalviainen, T. J. O'Brien, J. W. Sander, J. S. Duncan, I. E. Scheffer, S. F. Berkovic
Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study
The Lancet Neurology     PMID: 17913586     (Nov 2007)

G. L. Cavalleri, N. M. Walley, N. Soranzo, J. Mulley, C. P. Doherty, A. Kapoor, C. Depondt, J. M. Lynch, I. E Scheffer, A. Heil, A. Gehrmann, P. Kinirons, S. Gandhi, P. Satishchandra, N. W. Wood, A. Anand, T. Sander, S. F Berkovic, N. Delanty, D. B. Goldstein and S. M. Sisodiya.
A multicentre study of BRD2 as a risk factor for juvenile myoclonic epilepsy
Epilepsia     PMID: 17437413     (Apr 2007)

J.P. Casas, G. L. Cavalleri, A. Hingorani
Endothelial Nitric Oxide Synthase Gene Polymorphisms and Cardiovascular Disease: A HuGE Review
American Journal of Epidemiology     PMID: 17018701     (Nov 2006)

Tate SK, Singh R, Hung CC, Tai JJ, Depondt C, Cavalleri GL, Sisodiya SM, Goldstein DB, Liou HH.
A common polymorphism in the SCN1A gene associates with phenytoin serum levels at maintenance dose.
Pharmacogenet Genomics     PMID: 17001291     (Oct 2006)

P. Kinirons*, G. L. Cavalleri*, A. Shahwan, N. W. Wood, D. B. Goldstein, S. M Sisodiya, N. Delanty, C. P Doherty
Examining the role of common genetic variation in the gamma2 subunit of the GABA(A) receptor in epilepsy using tagging SNPs
Epilepsy Research     PMID: 16806831     (Aug 2006)

P. Kinirons*, G. L. Cavalleri*, R. Singh, A. Sharwan, J. F. Acheson, N. W. Wood, D. B. Goldstein, S. M. Sisodiya, C. P. Doherty and N. Delanty
A Pharmacogenetic Exploration of Vigabatrin-induced Visual Field Constriction.
Epilepsy Research     PMID: 16675198     (Aug 2006)

Sisodiya SM, Ragge NK, Cavalleri GL, Hever A, Lorenz B, Schneider A, Williamson KA, Stevens JM, Free SL, Thompson PJ, van Heyningen V, Fitzpatrick DR.
Role of SOX2 mutations in human hippocampal malformations and epilepsy
Epilepsia     PMID: 16529618     (May 2006)

D. B. Goldstein, G. L. Cavalleri
Genomics: understanding human diversity
Nature     PMID: 16251937     (Oct 2005)

G. L. Cavalleri, C. Depondt, M.W Burley, N. W. Wood, S. M. Sisodiya and D. B. Goldstein
Failure to replicate any reported genetic associations with sporadic temporal lobe epilepsy: lessons for the study of complex traits
Brain     PMID: 15888540     (Aug 2005)

S. K. Tate*, C. Depondt*, S. M. Sisodiya, G. L. Cavalleri, S. Schorge, N. Soranzo, M. Thom, A. Sen, S. D. Shorvon, J. W. Sander, N. W. Wood, and D. B. Goldstein
Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin
PNAS     PMID: 15805193     (Apr 2005)

N. Soranzo, G. L. Cavalleri, N. W. Wood, M. E. Weale, S. M. Sisodiya, D. B.Goldstein
Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene
Genome Research     PMID: 15197162     (Jul 2004)

Cinnioðlu C, King R, Kivisild T, Kalfoðlu E, Atasoy S, Cavalleri GL, Lillie AS, Roseman CC, Lin AA, Prince K, Oefner PJ, Shen P, Semino O, Cavalli-Sforza LL, Underhill PA.
Excavating Y-chromosome haplotype strata in Anatolia.
Hum Genet.     PMID: 14586639     (Jan 2004)

D. B. Goldstein, G. L. Cavalleri, K. R. Ahmadi
The genetics of common diseases: 10 million times as hard
Cold Spring Harb Symp Quant Biol     PMID: 15338641     (Oct 2003)

G. Passarino, G. L. Cavalleri, A. A. Lin, L. L. Cavalli-Sforza, A. L. Borresen-Dale, P. A. Underhill
Different genetic components in the Norwegian population revealed by the analysis of mtDNA and Y chromosome polymorphisms
The European Journal of Human Genetics.     PMID: 12173029     (Sep 2002)

Research Team
Post-doctoral researchers

Dr Katherine Benson

Dr Robert Carton

Dr Tania Kawasaki

Current Students

Ciarán Campbell (PhD / 4 yrs)

Edmund Gilbert (PhD / 4 yrs)

Caragh Stapleton (PhD / 3 yrs)

Academic staff

Dr Marie Greally (Clinical Data Manager)

Ms Gillian Murphy (Research Assistant)