Edmund is interested in the genetic structure and diversity in the Irish population. He has previously studied Biochemistry and Genetics (MSci) in the University of Nottingham, UK, and moved to Ireland to study for a PhD in Jan 2015. By utilising the Irish DNA Atlas, a cohort of individuals with ancestry from specific regions in Ireland; Edmund is studying the impact of human population structure and past migrations on the genetic landscape of Ireland, revealing groups of genetically related individuals with ancestries from similar regions across Ireland. In addition, Edmund is also currently investigating the population genetics within Irish Travellers, an isolated Irish-ancestry population predominantly found within Ireland. He is interested in the genetic structure within this population, and how this can be leveraged to study the genetic history and the genetics of disease within the Irish Travellers.
Caragh is a PhD student in the Human Genetic Variation Group with particular interest in predicting risk of disease and transplant-related outcomes using genetic markers. She received a BA in Genetics from Trinity College Dublin shortly before joining the Human Genetic Variation Group in 2014. Her PhD investigates the role of genetic variation in renal disease and transplant outcomes. Increasing evidence has indicated the influence of genetic variation on both end stage kidney disease and transplant outcomes. Her work examines the impact of different forms of genetic variation on transplant outcomes and complications including kidney graft function and post-transplant malignancy. A variety of techniques are used in these analyses to examine the different ways common genetic variation can predict disease risk - including genome-wide association studies, pathway analysis, polygenic risk analyses and shared-ancestry analyses. Caragh is also investigating a common form of end-stage kidney disease, IgA nephropathy. For this analysis, an exome sequencing approach is used to decipher whether rare genetic variants predispose disease risk in families with IgA nephropathy.
Ciarán is studying the genetic basis of psychiatric issues in epilepsy. People with epilepsy are at an increased risk for a variety of psychiatric conditions such as depression, psychosis and schizophrenia. Despite this, the genetic contribution to these comorbidities remains largely unexplored. Through the use of analytical techniques such as polygenic risk scoring Ciarán is seeking to determine if previously identified risk variants for a variety of psychiatric conditions are enriched in epilepsy patients who have the given psychiatric condition as a co-morbidity. Ciarán is also researching the role of genetic variation in adverse drug reactions to the anti-epileptic drug levetiracetam. Roughly 13% of patients prescribed levetiracetam experience psychosis or behavioural disorders in response to drug treatment. Through the use of exome sequencing, as well as GWAS and polygenic risk score analysis on patients who experience behavioural and psychotic side-effects to levetiracetam, he is aiming to explore the role of both rare and common genetic variation in these adverse drug reactions. This research will hopefully be useful in the future for personalising epilepsy patients’ treatments.
Edmund Gilbert BSc,MSc
Edmund is interested in the genetic structure and diversity in the Irish population. He has previously studied Biochemistry and Genetics (MSci) in the University of Nottingham, UK, and moved to Ireland to study for a PhD in Jan 2015. By utilising the Irish DNA Atlas, a cohort of individuals with ancestry from specific regions in Ireland; Edmund is studying the impact of human population structure and past migrations on the genetic landscape of I More...
E-mail: ed_gilund@hotmail.co.uk


Caragh Stapleton BA
Caragh is a PhD student in the Human Genetic Variation Group with particular interest in predicting risk of disease and transplant-related outcomes using genetic markers. She received a BA in Genetics from Trinity College Dublin shortly before joining the Human Genetic Variation Group in 2014. Her PhD investigates the role of genetic variation in renal disease and transplant outcomes. Increasing evidence has indicated the influence of genetic va More...
E-mail: caraghstapleton@rcsi.ie


Ciarán Campbell BA
Ciarán is studying the genetic basis of psychiatric issues in epilepsy. People with epilepsy are at an increased risk for a variety of psychiatric conditions such as depression, psychosis and schizophrenia. Despite this, the genetic contribution to these comorbidities remains largely unexplored. Through the use of analytical techniques such as polygenic risk scoring Ciarán is seeking to determine if previously identified risk variants for a varie More...
E-mail: CiaranCampbell@rcsi.ie